Results 61 to 70 of about 492,557 (263)

Chimeric antigen receptor (CAR) -T cell therapy treatment Richter's transformation

Frontiers in Oncology
Background/purposeDespite advances in chronic lymphocytic leukemia treatment, effective therapies for cases with Richter’s transformation (RT) are urgently needed. This study aimed to investigate the use of chimeric antigen receptor (CAR)-T cell infusion
Shaomei Feng, Peihao Zheng, Haidi Liu, Meiling Sun, Yuelu Guo, Lixia Ma, Rui Liu, Zhonghua Fu, Fan Yang, Xiaoyan Ke, Kai Hu   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Immune microenvironment and its influence on CAR-T treatment outcomes in B-NHL

Discover Oncology
B-cell non-Hodgkin’s lymphoma (B-NHL) is a highly heterogeneous tumor. Currently, CAR-T cells have been widely used in the treatment of B-cell lymphomas, with a complete response rate reaching 40%-60%.
Danyang Li, Zhonghua Fu, Rui Liu, Fan Yang, Ting Zhang, Lixia Ma, Yuelu Guo, Miaomiao Cao, Biping Deng, Alex H. Chang, Xiaoyan Ke, Kai Hu   +11 more
doaj   +1 more source

Spontaneous regression of mantle cell lymphoma: a report of four cases

Cancer Communications, 2018
Background Spontaneous regression has been reported in some indolent forms of lymphoma. Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm and has a poor prognosis.
Haige Ye, Aakash Desai, Tiejun Gong, Dongfeng Zeng, Krystle Nomie, Wendy Chen, Wei Wang, Jorge Romaguera, Michael L. Wang   +8 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

P072: Impact of Ageing on the Survivorship Experiences of Patients with Hodgkin Lymphoma

HemaSphere, 2022
Cherie Bates, Funmi Bamigbola, Lorna Warwick   +2 more
doaj   +1 more source

BEND4: a novel prognostic biomarker in diffuse large B-cell lymphoma

Discover Oncology
Background BEN domain-containing protein 4 (BEND4) is implicated in various cancer-related processes, but its role in diffuse large B-cell lymphoma (DLBCL) remains unclear.
Yanfang Wang, Zhenhao Zhang, Lianyong Xi, Hua Wang, Fei Dong   +4 more
doaj   +1 more source

DKN-01 and atezolizumab as second- or third-line therapy in advanced oesophagogastric adenocarcinoma: the WAKING trial

ESMO Gastrointestinal Oncology
Background: Survival for patients with advanced oesophagogastric adenocarcinoma (OGA) is poor. Immune checkpoint inhibitor (ICI) monotherapy has limited efficacy in mismatch repair proficient (MMRp) OGA.
A. Gordon, E. Cartwright, A. Tran, R. Crux, F. Turkes, E. Smyth, A. Smith, I. Manalang, I. Rana, D. Kohoutova, E. Johnston, A. Dunlop, M.S. Ul-Islam, S. Falk, A. Sita-Lumsden, S. Rao, N. Starling, I. Chau, D. Cunningham   +18 more
doaj   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among U.S. Veterans

Arthritis Care &Research, Accepted Article.
Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source