Results 151 to 160 of about 88,412 (297)

Toward Personalized Medicine in Type 1 Diabetes: Understanding How Patient Heterogeneity Influences Therapeutic Efficacy

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4529-4545, June 2026.
ABSTRACT Pharmacologic interventions for type 1 diabetes (T1D) have advanced significantly in recent years with the advent of the first FDA approved therapy teplizumab for delaying symptomatic disease onset in 2022. Despite this progress, major hurdles remain in moving toward personalized medicine approaches for T1D.
Jasmine Pipella, Peter J. Thompson
wiley   +1 more source

Specific Deficiency of Naïve CD4+ T Lymphocytes Characterizes Heart Failure and Heightens Mortality Risk in the HRS. [PDF]

J Am Heart Assoc
Zidar DA, Freeman ML, Wilson BM, Al-Kindi S, Chung MK, Gunzler DD, Parikh SA, Sharma AA, Shive CL, Jain M, Skarbinski J, Tang WHW, Dalton JE, Anthony DD, Chan TA, Thyagarajan B.   +15 more
europepmc   +1 more source

Neutrophil‐to‐Lymphocyte Ratio as a Predictor of Cardiovascular Events in Psoriatic Disease: A Retrospective Cohort Study

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective The aim of this study was to evaluate the neutrophil‐to‐lymphocyte ratio (NLR) as an independent predictor of major adverse cardiovascular events (MACEs) and all‐cause mortality in patients with psoriasis (PsO) or psoriatic arthritis (PsA). Methods We conducted a retrospective cohort study of 967 patients (825 with PsO and 142 with PsA) at a ...
Mauro Martini, Luciano Logiudice, Luis D. Mazzuoccolo, Nicolas Alvarado, Alfredo Vargas Caselles, Paola De La Torre, Valentina Torres Londono, Maria Laura Acosta Felquer, Javier Rosa, Enrique R. Soriano   +9 more
wiley   +1 more source

How Does Lymphocyte Depletion Affect Rectal Cancer Radiotherapy Outcomes? [PDF]

Cureus
Dahbi Z, El Mjabber R, Alami R, Harrar Y, Guessous F.   +4 more
europepmc   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Acquired Immunodeficiency in Newborn Following Intrauterine Exposure to Thiopurines for Treatment of Inflammatory Bowel Disease. [PDF]

ACG Case Rep J
Morand S, Lam MT, Amornsawadwattana S, Gutierrez A, Nguyen AA, Prockop S, Ruggiero J, Kitcharoensakkul M.   +7 more
europepmc   +1 more source

A Versatile Polymer‐Based In Situ Nanovaccine to Boost Cancer Immunotherapy

Aggregate, Volume 7, Issue 5, May 2026.
A polymer‐based in situ nanovaccine (PCR‐NPs) orchestrates a powerful antitumor immune cascade via integrated antigen release, capture, and lymph nodes transport, eliciting potent CD8+ T cell responses that drive significant tumor inhibition and prolonged mice survival in murine tumor models.
Qi‐Song Tong, Na Shu, Hua Huang, Wei Xu, Wen‐Chuan Xie, Quan Xia, Jin‐Zhi Du   +6 more
wiley   +1 more source

Predictors of acute lymphopenia after radiotherapy for prostate cancer including pelvic node irradiation: results of a real-world prospective multi-centric study. [PDF]

ESMO Real World Data Digit Oncol
Vavassori V, Pavarini M, Alborghetti L, Aimonetto S, Maggio A, Landoni V, Ferrari P, Bianculli A, Petrucci E, Cicchetti A, Farina B, Ubeira-Gabellini MG, Salmoiraghi P, Moretti E, Avuzzi B, Giandini T, Munoz F, Magli A, Noris Chiorda B, Sanguineti G, Waskiewicz JM, Rago L, Cante D, Girelli G, Villa E, Di Muzio NG, Rancati T, Fiorino C, Cozzarini C.   +28 more
europepmc   +1 more source

Noonan Syndrome Spectrum Disorders Predispose to Systemic Lupus Erythematosus: Case Report and Critical Review of the Literature

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1091-1097, May 2026.
ABSTRACT RASopathies are clinically overlapping neurodevelopmental syndromes resulting from germline mutations in genes involved in the rat sarcoma/mitogen‐activated protein kinases (RAS/MAPK) pathway. Historically, RASopathies have been described by clinical phenotypes, such as Noonan syndrome and Neurofibromatosis type I.
Anastasia‐Vasiliki Madenidou, Gillian I. Rice, James O'Sullivan, Ben Parker, Ian N. Bruce, Emma Burkitt‐Wright, Tracy A. Briggs   +6 more
wiley   +1 more source

Normal tissue complication probability modeling of severe radiation-induced lymphopenia using blood dose for lung cancer patients treated with IMRT and IMPT. [PDF]

Front Immunol
Wang S, Dai T, Fan X, Li W, Huang W, Wang R, Yin Y.   +6 more
europepmc   +1 more source