Safety of upadacitinib in atopic dermatitis in randomized clinical trials across 6 years
The current study found no evidence of cumulative increased safety risks with upadacitinib 15 or 30 mg for up to 6 years and over 9000 patient‐years of safety data in adults and adolescents. There were low rates of adjudicated major adverse cardiovascular events, adjudicated thromboembolic events and malignancies. Abstract Background Atopic dermatitis (
Christopher G. Bunick +13 more
wiley +1 more source
Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients. [PDF]
Cidade JP +8 more
europepmc +1 more source
Signatures of Radiation‐Induced Stress and Putative Selection on Immune Targets in Chornobyl Wolves
ABSTRACT Investigating the physiological and evolutionary consequences of contaminant exposure in wild populations is critical for understanding long‐term ecological impacts of anthropogenic change. However, how and why species persist, even thrive, in highly contaminated regions in the absence of humans remains a topic of much debate.
Cara N. Love +9 more
wiley +1 more source
Safety and efficacy of oral cladribine in relapsing multiple sclerosis: a systematic review and meta-analysis. [PDF]
Alnajashi H +10 more
europepmc +1 more source
Identification of a Sjogren\u27s syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons [PDF]
et al.,, Huang, Andrew J. W.
core +1 more source
ABSTRACT A 4‐year‐old male intact Kerry Blue Terrier presented with lethargy, pyrexia, intermittent cough, and a large, firm right ventral cervical mass. Contrast‐enhanced head and neck CT revealed a focally expansile, ill‐defined, mixed‐attenuation lesion with gas bubbles, suggestive of extensive cellulitis and abscessation, in close communication ...
Flavia Thaysa Vieira Freitag +4 more
wiley +1 more source
Natural History of Swiss Infants with Non-SCID T-cell Lymphopenia Detected by Newborn Screening: A Cohort Study. [PDF]
Soomann M +9 more
europepmc +1 more source
Abstract Objective To describe the procedure and short‐term outcomes of two dogs that underwent laparoscopic stapled partial cystectomy with intraoperative cystoscopy for excision of solitary, non‐trigonal, urothelial carcinoma lesions. Animals A 12‐year‐old female spayed mixed breed and a 13‐year‐old female spayed Siberian Husky.
Maureen A. Griffin +2 more
wiley +1 more source
Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022-2025. [PDF]
Boyarchuk O +19 more
europepmc +1 more source
The preparation and testing of horse antidog and antihuman antilymphoid plasma or serum and its protein fractions. [PDF]
Amend, JR +5 more
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