Results 211 to 220 of about 88,412 (297)

Abscopal effect induced by conventional fractionated radiotherapy following anti-PD-1 immunotherapy in pulmonary metastatic thymic squamous cell carcinoma: a case report and literature review. [PDF]

Front Immunol
Cui M, He J, Zhang F, Zhang Y, Gao A, Liu J.   +5 more
europepmc   +1 more source

Elranatamab: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Elranatamab (ELREXFIO) is a humanized bispecific antibody approved for patients with relapsed/refractory multiple myeloma (RRMM). Elranatamab engages CD3 on T cells and B‐cell maturation antigen (BCMA) on myeloma cells to induce T cell–mediated myeloma cell cytolysis.
Mohamed Elmeliegy, Andrea Viqueira, Erik Vandendries, Pooneh Soltantabar, Hoi‐Kei Lon, Kamrine Poels, Blerta Shtylla, Donald Irby, Kristin Bompiani‐Myers, Thomas O'Brien, Jennifer Hibma   +10 more
wiley   +1 more source

Radiation-induced severe lymphopenia predicts distant metastasis in rectal cancer: dosimetric implications for immune-sparing radiotherapy. [PDF]

Radiat Oncol
Cheng YC, Huang WY, Shen PC, Chen FM, Lee MS, Yang JF, Chang HC, Chang WC, Chen JH, Lo CH.   +9 more
europepmc   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Teplizumab in Stage 2 Type 1 Diabetes: Clinical Practice Experience on Feasibility in 3 Adult Patients

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4326-4334, May 2026.
ABSTRACT Aim To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.
V. Guarnotta, F. Pantò, E. Vigneri, G. Piombo, M. I. Mineo, L. Tomasello, G. Arnaldi   +6 more
wiley   +1 more source

Unveiling relative lymphopenia and elevated monocyte-to-lymphocyte count as novel independent adverse prognostic factors in chronic myelomonocytic leukemia (CMML)-Proposal of the objective prognostic index for CMML (OPIC). [PDF]

Hemasphere
Calvo X, Rial-Villavecchia A, Roman-Bravo D, Garcia-Avila S, Gomez-Perez L, Salido M, Puiggros A, Espinet B, Fernandez-Rodriguez C, Tazon-Vega B, Bellosillo B, Castaño-Díez S, Díaz-Beyá M, Esteve J, Lome C, Colomo L, Florensa L, Ferrer Del Álamo A, Rodriguez-Sevilla JJ, Arenillas L.   +19 more
europepmc   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Acute severe cholestatic hepatitis and lymphopenia characterize pediatric hepatitis-associated aplastic anemia. [PDF]

J Pediatr Gastroenterol Nutr
Tegtmeyer D, Tsaka S, Lehmberg K, Höfs M, Beime J, Briem-Richter A, Oh J, Lainka E, Schulz-Jürgensen S.   +8 more
europepmc   +1 more source

Integrating Flow Cytometry in the Diagnostic Work of HIV‐Associated Hodgkin's Lymphomas

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Hodgkin lymphoma (HL) is prevalent worldwide and typically presents symptoms like sudden pain, swelling, and weight loss. Classical HL (cHL) is largely treatable with modern risk‐adapted and response‐based therapy. cHL represents one of the most common malignancies occurring during the course of evolution in patients living with HIV.
Maria Santa, Diana Cenariu, Adrian‐Bogdan Tigu, Marc Damian, Patricia Rantshabeng, Tendani Gaolathe, Andrew K. Ndlovu, Khalid Abdelrahman, Madalina Nistor, David Kegyes, Diana Gulei, Cristian Jinca, Anamaria Bancos, Ioana Rus, Horia Bumbea, Victor Tomacinschii, Sanda Buruiana, Rand Bilal, Cristina Selicean, Mihnea Zdrenghea, Bogdan Fetica, Cristina Stefan, Jonathan Fromm, Ciprian Tomuleasa   +23 more
wiley   +1 more source

Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and Is Associated with Immune Alterations. [PDF]

Pharmaceutics
Daly MB, Kim D, Inusah S, Little D, Kim JS, Makarova N, Edwards TE, Mitchell J, Heneine W, Pan Y, Dobard CW, García-Lerma JG.   +11 more
europepmc   +1 more source