Results 141 to 150 of about 67,139 (243)

Formulation Matters: The Overlooked Engine of Stability and Success in Antibody-Drug Conjugates. [PDF]

Pharmaceuticals (Basel)
Torres-Dias L, Moore E, Shukla S, Dash AK.   +3 more
europepmc   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Evaluation of Three Sample Preparation Methods for LC-HRMS Suspect Screening of Contaminants of Emerging Concern in Effluent Wastewater. [PDF]

Anal Chem
Orlando-Véliz D, Bonansea RI, García-Vara M, Nikolopoulou V, López de Alda M.   +4 more
europepmc   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

A Naked Lyophilized mRNA Vaccine Against Seasonal Influenza, Administered by Jet Injection, Provides a Robust Response in Immunized Mice. [PDF]

Vaccines (Basel)
Sharabrin SV, Krasnikova SI, Kisakov DN, Borgoyakova MB, Yakovlev VA, Tigeeva EV, Starostina EV, Litvinova VR, Kisakova LA, Vahitov DI, Makarova KP, Volosnikova EA, Ivanova KI, Bondar AA, Rudometova NB, Rudometov AP, Ilyichev AA, Karpenko LI.   +17 more
europepmc   +1 more source

Glucose induces lipolytic cleavage of a glycolipidic plasma membrane anchor in yeast [PDF]

, 1993
Bandlow, Wolfhard, Müller, Günter
core   +2 more sources

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

Detailed Method for the Purification of Rhamnogalacturonan-I (RG-I) in <i>Arabidopsis thaliana</i>. [PDF]

Bio Protoc
Zhang L, Javaid T, Urbanowicz BR.
europepmc   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Hyperspectral Imaging Techniques for Lyophilization: Advances in Data-Driven Modeling Strategies and Applications. [PDF]

Adv Sci (Weinh)
Yu H, Srisuma P, Devos C, Wang J, Myerson AS, Braatz RD.   +5 more
europepmc   +1 more source