Results 171 to 180 of about 50,534 (301)

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Effect of pretreatment, lyophilization parameters, and different cryoprotectants on the efficiency of probiotic freeze-drying immobilization process

Lyophilization is an excellent process to increase the shelf life of food products. It is also used to preserve probiotics. Living cells prefer mild conditions and any deviation, such as vacuum, high or low temperatures, leads to cell damage and death.
Krunić, Tanja, Osmokrović, Andrea
core   +1 more source

Olive Leaves for Functional Herbal Infusions: Effects of Post-Harvest Processing on Bioactive Properties, α-Amylase Inhibition Activity and Consumer Safety. [PDF]

Molecules
Hnatova L, Knazicka Z, Kovacikova E, Galik B, Sramkova KF, Lenicka D, Janco I, Tomka M, Grygorieva O, Jurikova T, Mlcek J, Capcarova M.   +11 more
europepmc   +1 more source

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

A rapid, sensitive, and field-deployable RAA-EsCas13d platform for detection of porcine adenovirus type 3. [PDF]

Microbiol Spectr
Li Y-y, Zhang H, Shao L-n, Liu B-l, Wang Y-m, Duan J-q, Lai S-Y, Xu Z-w, Zhu L.   +8 more
europepmc   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Lyophilized rumen fluid from goats fed different roughage-based diets: fermentation characteristics, microbial communities, and post-reconstitution <i>in vitro</i> fermentation performance. [PDF]

Front Microbiol
Na M, Guo W, Zhang R, Du H, Li K, Zhang J, Na R.   +6 more
europepmc   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Study on the Freezing Protection Effect of Melatonin on <i>Lactobacillus plantarum</i> FQR. [PDF]

Foods
Feng Y, Wu Y, Wang M, Wang R, Song L, Mei L.   +5 more
europepmc   +1 more source

Optimization of lyophilization process for polymeric nanoparticles

Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Mentor: PharmDr. Ondřej Holas, PhD. Consultant: Mgr.
Hatalová, Daniela
core