Results 191 to 200 of about 40,837 (264)

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Amplification, purification, and lyophilization of mycobacteriophages for therapeutic use. [PDF]

Microbiol Spectr
Viland MD, Abad L, Jacobs-Sera D, Freeman KG, Russell DA, Garlena RA, Mowry E, Yu S, Lauer MJ, Vehring R, Guerrero-Bustamante C, Hatfull GF.   +11 more
europepmc   +1 more source

Chemical‐Biological Fixation for Enhanced Bone Augmentation in Guided Bone Regeneration

Advanced Science, EarlyView.
M2N2ACa is an innovative injectable thermoresponsive barrier membrane adhesive to achieve reliable bone graft fixation. It provides strong wet adhesion and promotes the bio‐stabilization mediated by coagulation through controlled calcium release. This dual‐fixation strategy combines external chemical fixation and internal biological fixation via clot ...
Yu‐zhu Wang, Gao‐peng Dang, Zhi‐ting Li, Zhi‐hong Feng, Que Bai, Jia‐xin Hao, Xiao‐qing Cao, Tao Ye, Jing Li, Franklin R. Tay, Malcolm Xing, Ming Fang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

How Do Cryo-Milling and Lyophilization Affect the Properties of Solid Dispersions with Etodolac? [PDF]

Pharmaceutics
Czajkowska-Kośnik A, Wach RA, Wolska E, Winnicka K.   +3 more
europepmc   +1 more source

Evaluation of Three Sample Preparation Methods for LC-HRMS Suspect Screening of Contaminants of Emerging Concern in Effluent Wastewater. [PDF]

Anal Chem
Orlando-Véliz D, Bonansea RI, García-Vara M, Nikolopoulou V, López de Alda M.   +4 more
europepmc   +1 more source

Comparative Evaluation of QQ Media Materials for MBR Applications: An Environmental Footprint Approach in Urban Wastewater Treatment Plants. [PDF]

Membranes (Basel)
Korkusuz-Soylu S, Ardic-Demirbilekli R, Yilmaz M, Koyuncu I, Kose-Mutlu B.   +4 more
europepmc   +1 more source

A Naked Lyophilized mRNA Vaccine Against Seasonal Influenza, Administered by Jet Injection, Provides a Robust Response in Immunized Mice. [PDF]

Vaccines (Basel)
Sharabrin SV, Krasnikova SI, Kisakov DN, Borgoyakova MB, Yakovlev VA, Tigeeva EV, Starostina EV, Litvinova VR, Kisakova LA, Vahitov DI, Makarova KP, Volosnikova EA, Ivanova KI, Bondar AA, Rudometova NB, Rudometov AP, Ilyichev AA, Karpenko LI.   +17 more
europepmc   +1 more source

Formulation Matters: The Overlooked Engine of Stability and Success in Antibody-Drug Conjugates. [PDF]

Pharmaceuticals (Basel)
Torres-Dias L, Moore E, Shukla S, Dash AK.   +3 more
europepmc   +1 more source

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Lyophilization

2020
Due to the thermolability of food and pharmaceutical products the drying process cannot be performed at high temperature; lyophilization replaces then standard drying units taking advantage of sublimation instead of evaporation. Being freeze drying a batch operation, a suitable model is used to assess the operating residence time for given operating ...
Di Pretoro A., Manenti F.
openaire   +3 more sources