Results 231 to 240 of about 97,922 (330)

Critical Needs and Opportunities for Advanced Manufacturing of Lyophilized Injectables. [PDF]

Pharm Res
Alexeenko A, Korang-Yeboah M, Tchessalov S.   +2 more
europepmc   +1 more source

Model-based monitoring and control of industrial freeze-drying processes: Effect of batch nonuniformity [PDF]

, 2010
Antonello A. Barresi, Barresi A.A., Daniele L. Marchisio, Davide Fissore, Fissore D., Milton N., Oetjen G.W., Rasetto V., Roberto Pisano, Tang X.C., Tang X.C., Valeria Rasetto   +11 more
core   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Developing Subcutaneous Formulations for Irisin as a Potential Therapeutic. [PDF]

Pharm Res
Hu G, Luan X, Hageman MJ, Lou H.
europepmc   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Retainment of Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyhexanoate) Properties from Oil-Fermented <i>Cupriavidus necator</i> Using Additional Ethanol-Based Defatting Process. [PDF]

Polymers (Basel)
Choi TR, Lim G, Han Y, Jeon JM, Bhatia SK, Park HJ, Joo JC, Kim HT, Yoon JJ, Yang YH.   +9 more
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Incorporation of a Natural Deep Eutectic Solvent-Based System as a Cryoprotectant in Solid Lipid Nanoparticles: Advancing toward Industrial Scalability. [PDF]

ACS Nanosci Au
Florêncio I, Simões MM, Paiva KLR, Salgado LA, Silveira AP, Piau TB, Grisolia CK, Mello VC, Báo SN.   +8 more
europepmc   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source