Results 41 to 50 of about 61,774 (255)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Gycklare och socialrealistisk skildrare

open access: yesKulturella Perspektiv, 2009
Dolly Parton is one of the universally most beloved, and most widely respected women emerged from country music. In the article her lyrics is analysed from a class and gender perspective.
Mats Greiff
doaj   +1 more source

Automatic Lyrics-based Music Genre Classification in a Multilingual Setting [PDF]

open access: yes, 2011
A large amount of research has been undertaken with regard to the classification of lyrics into genres, but most of this work has featured solely English lyrics.
Johnson, Colin G.   +2 more
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Literary parody as a form of creative discussion

open access: yesTrudy Odesskogo Politehničeskogo Universiteta, 2015
The parody as a literary genre represents a multifaceted and complex phenomenon, allowing poets and writers to solve numerous creative tasks. However, the notion of “parody” does not correlate to a fixed, clear and comprehensive definition.
Lada V. Prokopovich
doaj   +3 more sources

Simpatías por el Mal: El discurso persuasivo en “Sympathy for the Devil” de los Rolling Stones y “Jesucristo García” de Extremoduro

open access: yesStudia Romanica Posnaniensia, 2010
Dealing with discourses produced in Contemporary Popular Music, it is usual in contemporary youth’s imaginary to find rock considered as metonymic with authenticity, remaining as a movement an outstanding extension of Romanticism.
Alfons Gregori i Gomis
doaj   +1 more source

Remixed Javaneseness: Lyrics of Levelling Adiluhung Non-Adiluhung [PDF]

open access: yes, 2019
In this paper, we respond to Nancy Florida’s work published in 1978, which describes how adiluhung as a trait of Javanese literature was a deliberate construction, which separated it from the non-adiluhung.
Edi Dwi Riyanto
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

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