Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang+9 more
wiley +1 more source
Dissolving porcine and human microthrombi by short exposure to microdoses of alteplase in an in vitro model of microvascular obstruction. [PDF]
Milusev A+7 more
europepmc +1 more source
Lysis of Bacterial Protoplasts and Spheroplasts by Staphylococcal α-Toxin and Streptolysin S [PDF]
Alan W. Bernheimer, Lois L. Schwartz
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This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li+9 more
wiley +1 more source
A Mg<sup>2+</sup>-dependent high-yield method for extracting high-molecular-weight genomic DNA from a single planarian specimen. [PDF]
Li A+7 more
europepmc +1 more source
Lysis of Escherichia coli by Ethylenediaminetetraacetate and Phospholipases as Measured by β-Galactosidase Activity [PDF]
Milton W. Slein, Gerald F. Logan
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Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi+13 more
wiley +1 more source
Isolation and relationship analysis of Listeria phages with various serotype hosts and morphological characterization. [PDF]
Chen J+13 more
europepmc +1 more source
Lysis of Staphylococcus aureus Cell Walls by a Soluble Staphylococcal Enzyme [PDF]
Eskin Huff, Carol S. Silverman
openalex +1 more source