Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. [PDF]
PLoS ONE, 2015 Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Yu Sun +3 more
doaj +19 more sources
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J. +6 more
core +3 more sources
HLA‒B*58:01 and skin reactions in pediatric hematology and oncology patients treated with allopurinol [PDF]
Clinical and Experimental PediatricsBackground Allopurinol is widely used to prevent hyperuricemia in patients with tumor lysis syndrome. However, its use can trigger severe cutaneous adverse reactions (SCARs) with a mortality rate of approximately 11.39%. The human leukocyte antigen (HLA)–
Parisa Maneechai +3 more
doaj +2 more sources
Jurnal Kimia Sains dan Aplikasi, 2019 Allopurinol sebagai obat tablet banyak beredar di pasaran, sehingga kadar allopurinol haruslah memenuhi persyaratan agar kualitas obat dijamin. Pada penelitian ini, validasi metode penentuan obat tablet allopurinol dalam tiga konsentrasi HCl, yaitu 0,05 ...
Suprianto Suprianto +3 more
doaj +3 more sources
The anti-inflammatory effect of allopurinol and diclofenac in chicks’ model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 No studies have been conducted on the anti-inflammatory effect of allopurinol; eight-day old chicks are used. The aim of this paper was to study the anti-inflammatory action of allopurinol on a chemical pain model, both when administered alone or in ...
Maab A. Fadel, Khayrea A. Mustafa
doaj +1 more source
Assessing willingness to pay for HLA-B*58:01 genetic testing before allopurinol initiation and its potential impact on future health policy, Thailand. [PDF]
Sci RepTowiwat P +4 more
europepmc +3 more sources
Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats
Journal of Pharmaceutical Health Care and Sciences, 2022 Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels.
Yoshitaka Tayama +5 more
doaj +1 more source
Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function:a randomised controlled trial [PDF]
, 2020 Background: Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired physical ...
Cavin, Ian +10 more
core +2 more sources
HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US. [PDF]
JAMA DermatolCampbell CN +4 more
europepmc +2 more sources