Allopurinol Use Is Associated with Decreased Incidence of Hepatic Decompensation and Overall Mortality among Individuals with Cirrhosis: A Propensity-Matched Cohort Study [PDF]
GE: Portuguese Journal of GastroenterologyBackground: Cirrhosis is associated with significant morbidity and mortality. Recent studies have highlighted the potential role of allopurinol in reducing the incidence of hepatic decompensation among individuals with cirrhosis.
Mohammad Al Hayek +13 more
doaj +2 more sources
The anti-inflammatory effect of allopurinol and diclofenac in chicks’ model [PDF]
Iraqi Journal of Veterinary Sciences, 2023 No studies have been conducted on the anti-inflammatory effect of allopurinol; eight-day old chicks are used. The aim of this paper was to study the anti-inflammatory action of allopurinol on a chemical pain model, both when administered alone or in ...
Maab A. Fadel, Khayrea A. Mustafa
doaj +1 more source
Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats
Journal of Pharmaceutical Health Care and Sciences, 2022 Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels.
Yoshitaka Tayama +5 more
doaj +1 more source
Clinical and Translational Science, 2020 The aims of this study were to determine factors that predict serum urate (SU) lowering response to allopurinol and the conversion of allopurinol to oxypurinol, and to determine a minimum therapeutic oxypurinol concentration.
Lisa K. Stamp +8 more
doaj +1 more source
An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites
Clinical and Translational Science, 2022 ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid‐lowering ...
Marc‐Olivier Pilon +11 more
doaj +1 more source
Impact of Urate Level on Cardiovascular Risk in Allopurinol Treated Patients. A Nested Case-Control Study. [PDF]
PLoS ONE, 2016 BACKGROUND:Gout gives rise to increased risk of cardiovascular events. Gout attacks can be effectively prevented with urate lowering drugs, and allopurinol potentially reduces cardiovascular risk.
Kasper Søltoft Larsen +3 more
doaj +1 more source
Delayed hypersensitivity reaction to allopurinol: A case report [PDF]
Malaysian Family Physician, 2023 Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout.
Mohammad Che Man +5 more
doaj +1 more source
A case series of allopurinol-induced toxic epidermal necrolysis
Indian Journal of Dermatology, 2011 This is a case series of allopurinol-induced toxic epidermal necrolysis. Revisiting the indications of using allopurinol in asymptomatic hyperuricemia and a critical reappraisal of the safety profile of allopurinol is done in this article.
Harneet Ranu +2 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions.
Bao Sun +25 more
doaj +1 more source
Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha).
Ricardo Zanetti Gomes +4 more
doaj +1 more source