Results 31 to 40 of about 20,877 (183)

Health Care Use Among Patients Presenting to Emergency Department for Gout Flares in Ontario, Canada: A Population‐Based Health Systems Analysis

Arthritis Care &Research, EarlyView.
Objective We characterized emergency department (ED) gout visits and identified patient characteristics and health services patterns contributing to ED presentations. Methods We conducted a population‐based study of ED gout visits in Ontario, Canada, between 2014 and 2023.
Timothy S. H. Kwok, Samantha Morais, William K. Silverstein, Clare L. Atzema, Gregory Choy, Priyanka Chandratre, Ping Li, Jessica Widdifield   +7 more
wiley   +1 more source

Does Allopurinol Prevent Post Endoscopic Retrograde Cholangio- Pancreatography Pancreatitis? A Randomized Double Blind Trial [PDF]

Acta Medica Iranica, 2011
Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a frequent complication either for diagnosis or treatment of pancreatobiliary diseases.
Mohammad Abbasinazari, Amir Houshang Mohammad Alizadeh, Kamyar Moshiri, Mohammad Amin Pourhoseingholi, Mohammad Reza Zali   +4 more
doaj   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Allopurinol Suppresses Azoxymethane-Induced Colorectal Tumorigenesis in C57BL/KsJ-db/db Mice

Gastrointestinal Disorders, 2020
Obesity and related metabolic disorders, including chronic inflammation and enhanced oxidative stress, are closely associated with the development and progression of colorectal cancer.
Junichi Kato, Yohei Shirakami, Kimihiro Yamaguchi, Taku Mizutani, Takayasu Ideta, Hiroshi Nakamura, Soranobu Ninomiya, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu   +11 more
doaj   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Chronic allopurinol treatment during the last trimester of pregnancy in sows: effects on low and normal birth weight offspring. [PDF]

PLoS ONE, 2014
Low-birth-weight (LBW) children are born with several risk factors for disease, morbidity and neonatal mortality, even if carried to term. Placental insufficiency leading to hypoxemia and reduced nutritional supply is the main cause for LBW. Brain damage
Elise T Gieling, Alexandra Antonides, Johanna Fink-Gremmels, Kim Ter Haar, Wikke I Kuller, Ellen Meijer, Rebecca E Nordquist, Jacomijn M Stouten, Elly Zeinstra, Franz Josef van der Staay   +9 more
doaj   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Allopurinol therapy in gout patients does not associate with beneficial cardiovascular outcomes: a population-based matched-cohort study. [PDF]

PLoS ONE, 2014
Previous studies have shown an association between gout and/or hyperuricemia and a subsequent increase in cardiovascular disease (CVD) outcomes. Allopurinol reduces vascular oxidative stress, ameliorates inflammatory state, improves endothelial function,
Victor C Kok, Jorng-Tzong Horng, Wan-Shan Chang, Ya-Fang Hong, Tzu-Hao Chang   +4 more
doaj   +1 more source

Fermentation‐Induced Modulation of Polyphenolic Contents and Medicinal Activities in Annona squamosa Seeds

Food Chemistry International, EarlyView.
The study compared the medicinal activities of polyphenols from fermented and unfermented seeds of Annona squamosa. The polyphenols were extracted and subjected to standard analysis. The major phenolic components of the fermented polyphenols and the unfermented polyphenols were found to be 4‐hydroxybenzoic and 4‐hydroxyphenylacetic acid, respectively ...
Shola Hezekiah Awojide, Abayomi Gideon Adeyemo, Christianah Dare, Oluseye Oladapo Abiona, Adedayo Olubunmi Adeboye, Omolara Oladipo‐Olalekan, Aminat Adebola Adeyemo, Yemisi Elizabeth Asibor, Emmanuel Oluwafemi Adeniyi, Bunmi Regina Bankole, Ezekiel Olumide Fadunmade   +10 more
wiley   +1 more source

Cardiovascular risk associated with allopurinol or benzbromarone treatment in patients with gout

Therapeutic Advances in Musculoskeletal Disease, 2022
Background: In previous studies, cardiovascular (CV) risk was increased in patients with gout. The effects of uric acid–lowering therapy on CV risk in gout patients have been investigated in numerous studies; however, allopurinol and benzbromarone have ...
Yeonghee Eun, Heewon Han, Kyunga Kim, Seonyoung Kang, Seulkee Lee, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha   +8 more
doaj   +1 more source