Results 41 to 50 of about 47,188 (263)

Evaluation of analgesic activity of allopurinol and febuxostat in experimental analgesic models in mice

Indian Journal of Pain, 2015
Background: Allopurinol and febuxostat are xanthine oxidase inhibitors which are used in the treatment of hyperuricemia and gout. Pain is one of the important symptoms in gout patients.
Promod D Shankpal, J H Hotwani, Kunal A Chitnis, Dnyanesh S Tadke, Vijay R Kokani   +4 more
doaj   +1 more source

Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses

Molecular Oncology, 2019
The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop transcriptomic signatures for ...
Iman Tavassoly, Yuan Hu, Shan Zhao, Chiara Mariottini, Aislyn Boran, Yibang Chen, Lisa Li, Rosa E. Tolentino, Gomathi Jayaraman, Joseph Goldfarb, James Gallo, Ravi Iyengar   +11 more
doaj   +1 more source

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney. [PDF]

, 2016
BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels.
Girardet, Jean-Luc, Hagerty, David T, Hyndman, David, Iverson, Cory, Liu, Sha, Manhard, Kimberly, Miner, Jeffrey N, Nanavati, Payal, Quart, Barry, Shen, Zancong, Tan, Philip K, Terkeltaub, Robert, Yeh, Li-Tain   +12 more
core   +2 more sources

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source

Allopurinol use associated with increased risk of acute myocardial infarction in older people in a case–control study

Tzu Chi Medical Journal, 2019
Objective: There is controversy about the association between the allopurinol use and the risk of acute myocardial infarction. The aim of the study was to examine the association between allopurinol use and acute myocardial infarction in older people in
Kuan-Fu Liao, Cheng-Li Lin, Shih-Wei Lai   +2 more
doaj   +1 more source

Effects of Causal Beliefs About Gout on Public Views About Gout Management: A Randomized Experimental Study

Arthritis Care &Research, EarlyView.
Objective Despite well‐described biologic causes, the public views unhealthy lifestyle choices as the primary cause of gout. This study investigated how causal beliefs about gout influence the public's views about its management. Methods In a randomized study, 201 members of the public viewed one of two 2‐minute videos about gout.
Rachel Murdoch, Borislav Mihov, Anne Horne, Keith J. Petrie, Gregory D. Gamble, Lachlan Fleck, Nicola Dalbeth   +6 more
wiley   +1 more source

Allopurinol in combination with thiopurine induces mucosal healing and improves clinical and metabolic outcomes in IBD

Therapeutic Advances in Gastroenterology, 2017
Background: Thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP) are common maintenance medications for inflammatory bowel disease (IBD).
Brigitte Moreau, Pierre Clement, Yves Theoret, Ernest G. Seidman   +3 more
doaj   +1 more source

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

Disseminated cutaneous gout: a rare manifestation of a common disease [PDF]

, 2020
Disseminated cutaneous gout is a rare atypical cutaneous manifestation of gout in which widespread dermal and subcutaneous tophi develop at extra-articular body sites.
Adler, Brandon L, Crew, Ashley, DeClerck, Brittney, Guzman, Ruben, Peng, David   +4 more
core  

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source