Results 61 to 70 of about 26,198 (235)

Allopurinol: Old Drug, New Indication in Neonates?

, 2017
Background: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal mortality and neurological morbidity, even despite hypothermia treatment.
Mario Rüdiger, Manon J.N.L. Benders, Derks, Jan B., Frank van Bel, Axel R. Franz, Bel, Frank van, Kim V. Annink, Annink, Kim V., Rüdiger, Mario, Benders, Manon J. N. L., Jan B. Derks, Franz, Axel R.   +11 more
core   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

Hepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose, Kota Tsuruya, Yusuke Mishima, Yoshitaka Arase, Koichi Shiraishi, Vu Thi Hao, Satsuki Ieda, Masayuki Tanaka, Sanae Isaki, Tatehiro Kagawa   +9 more
wiley   +1 more source

The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial

Arthritis Research & Therapy, 2017
Background The use of allopurinol in people with chronic kidney disease (CKD) remains one of the most controversial areas in gout management. The aim of this study was to determine the effect of baseline kidney function on safety and efficacy of ...
Lisa K. Stamp, Peter T. Chapman, Murray Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth   +7 more
doaj   +1 more source

Fatigue and mood disorders are highly prevalent in patients with inflammatory bowel disease: A single‐centre, cross‐sectional study using patient‐reported outcomes

Internal Medicine Journal, EarlyView.
Abstract Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), yet it remains under‐recognised in clinical practice. This study aimed to quantify fatigue among Australian patients with IBD and examine associations with disease control, psychological distress and quality of life (QoL).
Andrew Chen, Darren Wong
wiley   +1 more source

Effectiveness of Allopurinol and Quercetin inclusion in a complex treatment of stable angina pectoris – peculiarities of biomarkers and homeostatic indices changes

Zaporožskij Medicinskij Žurnal, 2017
Objective – to study the effectiveness of Allopurinol and Quercetin inclusion in a complex treatment of stable angina pectoris and peculiarities of biomarkers and homeostatic indices changes. Materials and Methods.
V.K. Tashchuk, Muhamed Vasek Obeid Al Salama, T. М. Amelina   +2 more
doaj   +1 more source

Development of Non-Genetic Risk Stratification Model of Severe Allopurinol Hypersensitivity (NoG-ALLOH Score): A Multicenter Study in Thailand

Journal of Clinical Rheumatology and Immunology
Background The side effect of allopurinol was severe allopurinol hypersensitivity (SAH). There are two major causes including genetic risk factor, HLA-B*58:01 and non-genetic risk factors including female, old age, renal impairment, inadequate starting ...
Patapong Towiwat, Suppachai Lawanaskol, Wichittra Tassaneeyakul, Chonlaphat Sukasem, Niwat Saksit, Nontaya Nakkam, Duangkamon Poolpun, Ticha Rerkpattanapipat, Jettanong Klaewsongkram, Pawinee Rerknimitr, Worawit Louthrenoo   +10 more
doaj   +1 more source

A randomized controlled study of allopurinol mouthwash in the prevention of 5-fluorouracil-induced oral mucositis

Journal of Health Science and Medical Research (JHSMR), 2009
Objectives: To formulate an allopurinol suspension; study the chemical and physical stability of the formulation and compare the efficacy and adverse drug reactions of a 5 mg/mL allopurinol mouthwash with a placebo in the prevention of 5-fluorouracil (5 ...
P Kaewmanee, P Wongpoowarak, P Sunpaweravong, S Kasiwong, W Wongpoowarak   +4 more
doaj  

2448 The effect of allopurinol on pediatric patients undergoing maintenance chemotherapy for acute lymphoblastic leukemia or lymphoblastic lymphoma

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: This study aims to assess the safety, feasibility, clinical benefits and pharmacodynamics of adding allopurinol to standard maintenance therapy that includes 6-mecaptopurine (6-MP) in pediatric patients with acute lymphoblastic ...
Mariam M. Bhuiyan, Gordon Cohen, Stacy Cooper   +2 more
doaj   +1 more source

Short‐ and long‐term outcome and quality of life assessment in dogs undergoing transvenous coil embolization of congenital intrahepatic portosystemic shunts

Veterinary Surgery, EarlyView.
Abstract Objective To evaluate short‐ and long‐term outcomes and health‐related quality of life (Hr‐QoL) in dogs with congenital intrahepatic portosystemic shunts (cIHPSS) treated using percutaneous transcatheter embolization (PTCE). Study design Single center retrospective and prospective study. Animals Sixty‐one client‐owned dogs.
Guillaume P. Chanoit, Peter Scott, Kieran Borgeat, Ivan Doran, Vicky Lipscomb, Ed J. Friend   +5 more
wiley   +1 more source

Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua [PDF]

, 2013
We evaluated the effect of chemotherapy with a sequential combined treatment of a low dose of benznidazole and allopurinol, in different schedules of administration, in experimental models of acute and chronic Trypanosoma cruzi infection.
Fichera, Laura Edith, Grosso, Noelia Lorena, Bua, Jacqueline Elena, López Alarcón, Maria Micaela, Riarte, Adelina, Laucella, Susana Adriana   +5 more
core   +1 more source