Results 71 to 80 of about 21,706 (181)

Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells.

PLoS ONE
Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis.
Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen   +13 more
doaj   +1 more source

Multisystem Complications in Non‐Transfusion‐Dependent β‐Thalassemia Intermedia: A Case Highlighting the Need for Early Intervention

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This case highlights that severe complications of non‐transfusion‐dependent β‐thalassemia may be preventable with appropriate monitoring and timely intervention; however, once established, multisystem complications can be challenging to treat.
Oldooz Aloosh, Seyedeh Esmat Hosseini, Mohammad Karimi   +2 more
wiley   +1 more source

A Post–NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Mohammed Solayman Hossain, Sukyung Kim, Md Tareque Aziz, Izaz Ahmed, Md Sarower Hossen Shuvo, Hyewon Yang, Yunjeong Jang, Minseo Kim, Seohyeon Jang, Yusol Kim, Soeun Oh, Yunseo Nam, Hoonhee Seo, Ho‐Yeon Song   +13 more
wiley   +1 more source

Association between allopurinol and hepatocellular carcinoma: analysis of genetic risk and patient survival

Discover Oncology
Background Despite the widespread clinical use of allopurinol for managing hepatocellular carcinoma (HCC) and gout, its potential hepatotoxicity and its effect on the risk of HCC remain unclear.
Yu-fu Li, Hui-wei Wang, Huan-yan Peng, Zhen-ying Zhang, Zhi-jia Yao, Yuan Meng, Dong-ye Yang   +6 more
doaj   +1 more source

Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study

Kidney Medicine
Rationale & Objective: Clinical trials have shown that serum uric acid reduction does not slow chronic kidney disease (CKD) progression in adults, but it is uncertain whether these findings apply to children.
Derek K. Ng, Matthew B. Matheson, George J. Schwartz, Katherine E. Kurgansky, Bradley A. Warady, Susan L. Furth   +5 more
doaj   +1 more source

What Is Your Diagnosis? Dermal Mass From the Left Forelimb of a Dog

Veterinary Clinical Pathology, EarlyView.
Heather D. McDavid, Miranda D. Vieson, Robert Armentano, Nicholas T. Noto   +3 more
wiley   +1 more source

Pharmacology of allopurinol [PDF]

Arthritis & Rheumatism, 1975
openaire   +2 more sources

Allopurinol use and risk of acute coronary syndrome in gout patients: a population-based cohort study in Sweden

BMJ Open
Objectives To investigate the impact of allopurinol use on the risk of first-ever acute coronary syndrome (ACS) event in patients with gout.Methods Using national and regional register data, we included all patients with a gout diagnosis at primary or ...
Ulf Lindström, Lennart Jacobsson, Mats Dehlin, Karin Bengtsson, Panagiota Drivelegka, Tatiana Zverkova Sandström   +5 more
doaj   +1 more source

Therapeutic Effects of Allopurinol on Left Ventricular Function in Patients with Chronic Heart Failure

پزشکی بالینی ابن سینا, 2010
Introduction & Objective: Heart failure that is a major health problem with increasing incidence with the aging of the population often occurs as a result of ischemia and coronary artery disease.
Alireza Rai, Soozan Khalgh Dost, Hashem Kazerani, Mohammad Rasool Ghadami   +3 more
doaj  

Influence of pharmacogenomic polymorphisms on allopurinol-induced cutaneous adverse drug reactions in Thai patients

BMC Medical Genomics
Background Allopurinol has been causing substantial morbidity and mortality particularly in Asian population by producing cutaneous adverse drug reactions (cADRs).
Gaidganok Sornsamdang, Patompong Satapornpong, Pimonpan Jinda, Thawinee Jantararoungtong, Napatrupron Koomdee, Therdpong Tempark, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Pawinee Rerknimitr, Papapit Tuchinda, Leena Chularojanamontri, Napatra Tovanabutra, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Chutika Srisuttiyakorn, Yuttana Srinoulprasert, Shobana John, Mohitosh Biswas, Chonlaphat Sukasem   +19 more
doaj   +1 more source