Results 11 to 20 of about 26,198 (235)

Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]

, 2009
Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D., Jacob George, George, Jacob   +2 more
core   +1 more source

PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese

Frontiers in Pharmacology, 2018
Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions.
Bao Sun, Bao Sun, Lin Cheng, Lin Cheng, Yan Xiong, Yan Xiong, Lei Hu, Zhiying Luo, Zhiying Luo, Maosong Zhou, Ji Li, Hongfu Xie, Fazhong He, Fazhong He, Xiaoqing Yuan, Xiaoqing Yuan, Xiaoping Chen, Xiaoping Chen, Hong-Hao Zhou, Hong-Hao Zhou, Zhaoqian Liu, Zhaoqian Liu, Xiang Chen, Xiang Chen, Wei Zhang, Wei Zhang   +25 more
doaj   +1 more source

Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha).
Ricardo Zanetti Gomes, Gabriela Moreira Mahle Romanek, Michella Przybycien, Danielli Cristina Amaral, Hugo Genki Kagawa Akahane   +4 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]

, 2008
<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Lees, K.R., Walters, M.R., Weir, C.J., Dawson, J., Muir, S.W., Sattar, N., Harrow, C.   +6 more
core   +1 more source

Allopurinol for Secondary Prevention in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Journal of Cardiovascular Development and Disease, 2023
Background: The effects of allopurinol in patients with cardiovascular disease are not well defined; therefore, the latest evidence is summarized in this study. Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched for
Yuyang Ye, Guangzhi Liao, Ting Liu, Xinru Hu, Xuefeng Chen, Lin Bai, Yong Peng   +6 more
doaj   +1 more source

Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)

Jurnal Biodjati, 2022
Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine.
Dian Fita Lestari, Fatimatuzzahra Fatimatuzzahra, Agnes Petra Sianipar, Shahnaz Shabrina Wulansari   +3 more
doaj   +1 more source

Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol

Journal of Family Medicine and Primary Care, 2016
Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent ...
Ashraf Jmeian, Amer Hawatmeh, Razan Shamoon, Fayez Shamoon, Michael Guma   +4 more
doaj   +1 more source

Examining the use of allopurinol: Perspectives from recent drug injury relief applications

Journal of the Formosan Medical Association, 2019
Background/purpose: Previous studies have reported that the indication and starting dose of allopurinol may be associated with the incidence of hypersensitive reactions.
Chu-Han Huang, Mei-Pei Chu, Wen-Wen Chen
doaj   +1 more source

Effects of Allopurinol as a xanthine oxidase inhibitor on depressive-like behavior of rats and changes in serum BDNF level

IBRO Neuroscience Reports, 2022
Background: Depression is a psychiatric disorder characterized by low mood and loss of interest in daily activities. Allopurinol, a xanthine oxidase blocker, is widely administered for the treatment of hyperuricemia.
Mahsa Hadipour Jahromy, Bahareh Baghchesara, Salar Javanshir   +2 more
doaj   +1 more source