Results 11 to 20 of about 20,877 (183)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Allopurinol for Secondary Prevention in Patients with Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Journal of Cardiovascular Development and Disease, 2023
Background: The effects of allopurinol in patients with cardiovascular disease are not well defined; therefore, the latest evidence is summarized in this study. Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched for
Yuyang Ye, Guangzhi Liao, Ting Liu, Xinru Hu, Xuefeng Chen, Lin Bai, Yong Peng   +6 more
doaj   +1 more source

Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)

Jurnal Biodjati, 2022
Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine.
Dian Fita Lestari, Fatimatuzzahra Fatimatuzzahra, Agnes Petra Sianipar, Shahnaz Shabrina Wulansari   +3 more
doaj   +1 more source

Examining the use of allopurinol: Perspectives from recent drug injury relief applications

Journal of the Formosan Medical Association, 2019
Background/purpose: Previous studies have reported that the indication and starting dose of allopurinol may be associated with the incidence of hypersensitive reactions.
Chu-Han Huang, Mei-Pei Chu, Wen-Wen Chen
doaj   +1 more source

Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol

Journal of Family Medicine and Primary Care, 2016
Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent ...
Ashraf Jmeian, Amer Hawatmeh, Razan Shamoon, Fayez Shamoon, Michael Guma   +4 more
doaj   +1 more source

Effects of Allopurinol as a xanthine oxidase inhibitor on depressive-like behavior of rats and changes in serum BDNF level

IBRO Neuroscience Reports, 2022
Background: Depression is a psychiatric disorder characterized by low mood and loss of interest in daily activities. Allopurinol, a xanthine oxidase blocker, is widely administered for the treatment of hyperuricemia.
Mahsa Hadipour Jahromy, Bahareh Baghchesara, Salar Javanshir   +2 more
doaj   +1 more source

Allopurinol reduces antigen-specific and polyclonal activation of human T cells

Frontiers in Immunology, 2012
Allopurinol is the most popular commercially available xanthine oxidase inhibitor and it is widely used for treatment of symptomatic hyperuricaemia, or gout. Although, several anti-inflammatory actions of allopurinol have been demonstrated in vivo and in
Damián ePérez-Mazliah, María Cecilia Albareda, María Gabriela Alvarez, Bruno Edgardo Lococo, Graciela Luciana Bertocchi, Marcos ePetti, Rodolfo eViotti, Susana Adriana Laucella   +7 more
doaj   +1 more source

Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia.

PLoS ONE, 2015
Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Yu Sun, Jacob George, Jacob George, Sonia Rocha   +3 more
doaj   +1 more source

Comparative Study of Allopurinol and Uralyt-4 in patients with Hyperuricemia in Diyala Governorate.

مجلة كلية الطب, 2014
Background: Hyperuricemia represents a major public health problem; approximately most population has hyperuricemia, serum uric acid ≥6.5 mg/dL in women and ≥7.0 mg/dL in men.
Zuhir M. Hussein, Areej A. Hussein, Qutaybaa G. Hussein   +2 more
doaj   +1 more source

Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA‐B*58:01

Frontiers in Genetics, 2022
Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens ...
Astri Ferdiana, Astri Ferdiana, Astri Ferdiana, Jajah Fachiroh, Dyah Ayu Mira Oktarina, Astrid Irwanto, Caroline Mahendra, Sri Awalia Febriana, Hardyanto Soebono   +8 more
doaj   +1 more source