The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics
Clinical and Translational Science, 2023 The genetic determinants of the allopurinol dose‐concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs).
Hailemichael Z. Hishe +6 more
doaj +3 more sources
Oxypurinol protects renal ischemia/reperfusion injury via heme oxygenase-1 induction [PDF]
Frontiers in Medicine, 2023 Renal ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) by increasing oxidative stress, inflammatory responses, and tubular cell death.
Hye Bin Kang +3 more
doaj +2 more sources
Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01 [PDF]
Scientific Reports, 2023 Allopurinol, widely used in gout treatment, is the most common cause of severe cutaneous adverse drug reactions. The risk of developing such life-threatening reactions is increased particularly for HLA-B*58:01 positive individuals.
Xuelu Huan +3 more
doaj +2 more sources
Screening and functional verification of potential metabolites for high fertility in sows [PDF]
Frontiers in NutritionBackgroundNutritional metabolism greatly influences the embryonic development and pregnancy outcomes. Exploring the metabolic differences between high and low fertility individuals plays pivotal roles in improving reproduction in mammals.ObjectiveThe ...
Ran Ning +19 more
doaj +2 more sources
Mass Spectrometric Analysis of Purine Intermediary Metabolism Indicates Cyanide Induces Purine Catabolism in Rabbits [PDF]
MetabolitesPurines are the building blocks of DNA/RNA, energy substrates, and cofactors. Purine metabolites, including ATP, GTP, NADH, and coenzyme A, are essential molecules in diverse biological processes such as energy metabolism, signal transduction, and enzyme
Jordan Morningstar +4 more
doaj +2 more sources
Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens [PDF]
Journal of Animal Science and BiotechnologyBackground Research on low-protein-level diets has indicated that even though the profiles of essential amino acids (EAAs) follow the recommendation for a normal-protein-level diet, broilers fed low-protein diets failed to achieve productive performance ...
Bin Wang +7 more
doaj +2 more sources
Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis [PDF]
Frontiers in ImmunologyObjectivePrevious research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome–metabolome interface in AS.
Yupeng Lai +8 more
doaj +2 more sources
Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase [PDF]
Journal of Biological Chemistry, 2023 Emil F Pai +2 more
exaly +2 more sources
Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture [PDF]
Nucleic Acids ResearchJörg S Hartig +2 more
exaly +2 more sources
Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia. [PDF]
PLoS ONE, 2012 Cancer cachexia is a wasting condition, driven by systemic inflammation and oxidative stress. This study investigated eicosapentaenoic acid (EPA) in combination with oxypurinol as a treatment in a mouse model of cancer cachexia. Mice with cancer cachexia
Vanessa C Vaughan +4 more
doaj +1 more source