Results 1 to 10 of about 524 (148)

The role of urate and xanthine oxidase in vascular oxidative stress: future directions [PDF]

Therapeutics and Clinical Risk Management, 2009
Jacob George, Allan StruthersDivision of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UKAbstract: Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction.
Jacob George, Allan Struthers
doaj   +2 more sources

Allopurinol-Induced DRESS Syndrome in Patients with Pre-Existing Chronic Kidney Disease: A Case Report and Comprehensive Literature Review

Case Reports in Dermatology
Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction that can be triggered by allopurinol, with increased risk in patients with chronic kidney ...
Ashraf Ahmed, Alaa Abdelhamid, Hidaya Al-Tamimi, Raghad Elashie, Elhassan Mahmoud, Ali Ibrahim Rahil   +5 more
doaj   +1 more source

Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis

Frontiers in Immunology
ObjectivePrevious research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome–metabolome interface in AS.
Yupeng Lai, Yupeng Lai, Wenli Tang, Xiao Luo, Huihui Zheng, Yanpeng Zhang, Meiying Wang, Guangchuang Yu, Min Yang   +8 more
doaj   +1 more source

Screening and functional verification of potential metabolites for high fertility in sows

Frontiers in Nutrition
BackgroundNutritional metabolism greatly influences the embryonic development and pregnancy outcomes. Exploring the metabolic differences between high and low fertility individuals plays pivotal roles in improving reproduction in mammals.ObjectiveThe ...
Ran Ning, Ran Ning, Jiale Bao, Jiale Bao, Yulan Zhao, Yulan Zhao, Yanlong Li, Yanlong Li, Zhekun Zhu, Zhekun Zhu, Shuang Cai, Shuang Cai, Xiangzhou Zeng, Xiangzhou Zeng, Xiangfang Zeng, Xiangfang Zeng, Xiangfang Zeng, Haiqing Sun, Fenglai Wang, Fenglai Wang   +19 more
doaj   +1 more source

An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia

Vascular Health and Risk Management, 2017
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Abstract: Several studies suggest that chronic hyperuricemia, the main ...
Bove M, Cicero AFG, Veronesi M, Borghi C
doaj  

Trichloroethylene 改变融合期内皮细胞一氧化氮和氧自由基的平衡

Zhongshan Daxue xuebao. Yixue kexue ban, 2004
【目的】Trichloroethylene(TRI)是一种与先天性心脏病发生有关的环境污染物,我们最近报道在分裂期的内皮细胞(EC)中,TRI可以通过减少热休克蛋白90(hsp90)与内皮一氧化氮合酶(eNOS)结合,从而抑制刺激状态下一氧化氮(NO)产生和增加刺激状态下eNOS依赖的超氧阴离子自由基()产生和抑制血管内皮生长因子刺激的内皮细胞分裂。但TRI在融合期EC中的影响仍未清楚。本实验目的是探讨TRI对融合期EC的影响。【方法】TRI5μmol/L预处理融合期EC ...
doaj  

Enhanced and Sustained Transdermal Delivery of Oxypurinol Using Thermosensitive Gel Combined with Polymeric Solid Microneedles

ACS Omega
Siti Nur Fatimah S. Mohamad, Stephanie Stephanie, Zulfiayu Sapiun, Frederika Tangdilintin, Sulistiawati Sulistiawati, Achmad Himawan, Yusnita Rifai, Habibie Habibie, Aliyah Aliyah, Muhammad Aswad, Andi Dian Permana   +10 more
doaj   +1 more source

The pharmacokinetics of oxypurinol in people with gout [PDF]

British Journal of Clinical Pharmacology, 2012
AIMS: Our aim was to identify and quantify the sources of variability in oxypurinol pharmacokinetics and explore relationships with plasma urate concentrations.
Sophie Stocker, Carl Kirkpatrick, Richard Day   +2 more
exaly   +9 more sources

Allopurinol and oxypurinol are hydroxyl radical scavengers [PDF]

FEBS Letters, 1987
Allopurinol is a scavenger of the highly reactive hydroxyl radical (k2 approx. 109 M−1s−1). One product of attack of hydroxyl radical upon allopurinol is oxypurinol, which is a major metabolite of allopurinol.
Barry Halliwell, Martin Grootveld, J M Gutteridge   +2 more
exaly   +5 more sources

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase [PDF]

Journal of Biological Chemistry, 2023
Xanthine oxidoreductase is a metalloenzyme that catalyzes the final steps in purine metabolism by converting hypoxanthine to xanthine and then uric acid.
Emil F Pai, Koji Nagata, Kimiyoshi Ichida   +2 more
exaly   +6 more sources