Results 31 to 40 of about 1,503 (160)

Binding of Xanthine Oxidase to Glycosaminoglycans Limits Inhibition by Oxypurinol [PDF]

Journal of Biological Chemistry, 2004
Although the binding of xanthine oxidase (XO) to glycosaminoglycans (GAGs) results in significant alterations in its catalytic properties, the consequence of XO/GAG immobilization on interactions with clinically relevant inhibitors is unknown. Thus, the inhibition kinetics of oxypurinol for XO was determined using saturating concentrations of xanthine.
Eric E, Kelley, Andrés, Trostchansky, Homero, Rubbo, Bruce A, Freeman, Rafael, Radi, Margaret M, Tarpey   +5 more
openaire   +2 more sources

Depressive Symptoms and the Effectiveness of a Urate‐Lowering Therapy in a Clinical Trial

ACR Open Rheumatology, 2020
Objective This ancillary study examined the impact of depressive symptoms on the effectiveness of a urate‐lowering therapy in the context of a clinical trial.
Sylvie Mrug, Catheryn Orihuela, Elizabeth Rahn, Amy Mudano, Jeffrey Foster, Kenneth Saag, Angelo Gaffo   +6 more
doaj   +1 more source

Altered Urinary Metabolomics in Hereditary Angioedema

Metabolites, 2022
Hereditary angioedema (HAE) is a rare and potentially life-threatening disease with heterogeneous clinical symptoms. The metabolomic profile of HAE remains unknown.
Xue Wang, Yuxiang Zhi
doaj   +1 more source

Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.

PLoS ONE, 2019
A fixed dose combination of lesinurad and allopurinol has been recently approved by USFDA and EMA for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone.
Muzaffar Iqbal, Essam Ezzeldin, Rashed Naji Herqash, Ozair Alam   +3 more
doaj   +1 more source

Simultaneous analysis of allopurinol and oxypurinol using a validated liquid chromatography–tandem mass spectrometry method in human plasma

Journal of Pharmaceutical Analysis, 2017
The present study describes a simple, reliable and reproducible liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for the simultaneous determination of allopurinol and its active metabolite, oxypurinol in human plasma for a pharmacokinetic/
Dhiraj M. Rathod, Keyur R. Patel, Hiren N. Mistri, Arvind G. Jangid, Pranav S. Shrivastav, Mallika Sanyal   +5 more
doaj   +1 more source

Does Allopurinol Prevent Post Endoscopic Retrograde Cholangio- Pancreatography Pancreatitis? A Randomized Double Blind Trial [PDF]

Acta Medica Iranica, 2011
Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a frequent complication either for diagnosis or treatment of pancreatobiliary diseases.
Mohammad Abbasinazari, Amir Houshang Mohammad Alizadeh, Kamyar Moshiri, Mohammad Amin Pourhoseingholi, Mohammad Reza Zali   +4 more
doaj   +1 more source

Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide

Journal of Pharmacological Sciences, 2011
.: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation.
Masashi Tawa, Kohei Yamamizu, Ayman Geddawy, Takashi Shimosato, Takeshi Imamura, Kazuhide Ayajiki, Tomio Okamura   +6 more
doaj   +1 more source

Comparative Study of the Lipophilicity of Selected Anti-Androgenic and Blood Uric Acid Lowering Compounds

Molecules, 2022
This study aimed to evaluate the lipophilicity of a series substances lowering the concentration of uric acid in blood and anti-androgen drugs by thin-layer chromatography in reversed-phase systems (RP-TLC, RP-HPTLC) and computational methods.
Dawid Wardecki, Małgorzata Dołowy, Katarzyna Bober-Majnusz, Josef Jampilek   +3 more
doaj   +1 more source

The Safety of Treating Women With Inflammatory Bowel Disease With Allopurinol and Low‐Dose Thiopurine During Pregnancy: A Single‐Center Experience

JCC Plus, Volume 1, Issue 4, July 2026.
ABSTRACT Background Low‐dose thiopurine therapy in combination with allopurinol (LD‐THIO/ALLO) is a widely used treatment for inflammatory bowel disease (IBD). However, little is known about the effects of in utero exposure to this combination on pregnancy and birth outcomes.
Kavitha Sivananthan, Signe Wildt, Marianne Kiszka‐Kanowitz, Gitte Pedersen, Ida Vind, Inge Nordgaard‐Lassen, Andreas Munk Petersen, Johan Burisch, Helle Kristensen, Klaus Theede   +9 more
wiley   +1 more source

Spatial Variability in Trace Organic Compound Reactivity During Urban River Infiltration Into an Alluvial Aquifer

Water Resources Research, Volume 62, Issue 5, May 2026.
Abstract Trace organic compounds (TrOCs) in lotic systems pose risks for ecosystem and human health. TrOCs can enter groundwater along losing river sections, yet little is known about the spatial extent of infiltration zones and the biogeochemical factors controlling the spatial variability of TrOC reactivity and removal, particularly along river‐to ...
Jonas L. Schaper, Olaf A. Cirpka, Malte Posselt, Joerg Lewandowski, Karin Meinikmann, Anke Putschew, Christiane Zarfl   +6 more
wiley   +1 more source