Results 31 to 40 of about 524 (148)
BMC Cancer, 2023 Background Pancreatic cancer is a highly lethal disease with no effective treatments. Lactobacillus casei (L. casei) and Lactobacillus reuteri (L. reuteri) exhibited therapeutic effects on several cancers, but their roles in pancreatic cancer are unknown.
Zemin Zhu +7 more
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Metabolites, 2023 The mechanisms responsible for the similar muscle growth attained with high- and low-load resistance training (RT) have not yet been fully elucidated. One mechanism is related to the mechanical stimulus and the level of motor unit recruitment; another ...
Denis F. Valério +3 more
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HYPERURICEMIA AS A PREDICTOR OF CHRONIC HEART FAILURE
Рациональная фармакотерапия в кардиологии, 2015 Aspects of comorbidity in patients with chronic heart failure are discussed. A focus on hyperuricemia, its effect on the course and prognosis in patients with heart failure, as well as the possibility of its medical correction are maintained.
M. V. Ledyakhova +2 more
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Oxidative stress and heart failure [PDF]
Archives of the Balkan Medical Union, 2019 Oxidative stress is involved in the pathophysiology of many chronic diseases, including heart failure. Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense.
Camelia C. Diaconu
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Effect of oxidative stress on the activity of human osteoblastic MG63 cells
口腔疾病防治, 2017 Objective To investigate the morphology and proliferation viability in oxidative stress induced damage in human MG63 cells. Methods The MG63 cells were treated with superoxide anion (O2.⁃) produced by different con⁃ centrations of xanthine/xanthine ...
WANG Qiong
doaj +1 more source
Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)
Jurnal Biodjati, 2022 Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine.
Dian Fita Lestari +3 more
doaj +1 more source
Depressive Symptoms and the Effectiveness of a Urate‐Lowering Therapy in a Clinical Trial
ACR Open Rheumatology, 2020 Objective This ancillary study examined the impact of depressive symptoms on the effectiveness of a urate‐lowering therapy in the context of a clinical trial.
Sylvie Mrug +6 more
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Altered Urinary Metabolomics in Hereditary Angioedema
Metabolites, 2022 Hereditary angioedema (HAE) is a rare and potentially life-threatening disease with heterogeneous clinical symptoms. The metabolomic profile of HAE remains unknown.
Xue Wang, Yuxiang Zhi
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Binding of Xanthine Oxidase to Glycosaminoglycans Limits Inhibition by Oxypurinol [PDF]
Journal of Biological Chemistry, 2004 Although the binding of xanthine oxidase (XO) to glycosaminoglycans (GAGs) results in significant alterations in its catalytic properties, the consequence of XO/GAG immobilization on interactions with clinically relevant inhibitors is unknown. Thus, the inhibition kinetics of oxypurinol for XO was determined using saturating concentrations of xanthine.
Eric E, Kelley +5 more
openaire +2 more sources
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D. +2 more
core +1 more source