Results 11 to 20 of about 1,837 (187)

Mass Spectrometric Analysis of Purine Intermediary Metabolism Indicates Cyanide Induces Purine Catabolism in Rabbits [PDF]

Metabolites
Purines are the building blocks of DNA/RNA, energy substrates, and cofactors. Purine metabolites, including ATP, GTP, NADH, and coenzyme A, are essential molecules in diverse biological processes such as energy metabolism, signal transduction, and enzyme
Jordan Morningstar, Jangwoen Lee, Sari Mahon, Matthew Brenner, Anjali K. Nath   +4 more
doaj   +2 more sources

Simultaneous analysis of allopurinol and oxypurinol using a validated liquid chromatography–tandem mass spectrometry method in human plasma

Journal of Pharmaceutical Analysis, 2017
The present study describes a simple, reliable and reproducible liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for the simultaneous determination of allopurinol and its active metabolite, oxypurinol in human plasma for a pharmacokinetic/
Dhiraj M. Rathod, Keyur R. Patel, Hiren N. Mistri, Arvind G. Jangid, Pranav S. Shrivastav, Mallika Sanyal   +5 more
doaj   +2 more sources

The role of urate and xanthine oxidase in vascular oxidative stress: future directions [PDF]

Therapeutics and Clinical Risk Management, 2009
Jacob George, Allan StruthersDivision of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UKAbstract: Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction.
Jacob George, Allan Struthers
doaj   +2 more sources

Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens [PDF]

Journal of Animal Science and Biotechnology
Background Research on low-protein-level diets has indicated that even though the profiles of essential amino acids (EAAs) follow the recommendation for a normal-protein-level diet, broilers fed low-protein diets failed to achieve productive performance ...
Bin Wang, Xiaodan Zhang, Yongfa Liu, Mingkun Gao, Mi Wang, Yuan Wang, Xinzhi Wang, Yuming Guo   +7 more
doaj   +2 more sources

Gut microbiome and metabolome to discover pathogenic bacteria and probiotics in ankylosing spondylitis [PDF]

Frontiers in Immunology
ObjectivePrevious research has partially revealed distinct gut microbiota in ankylosing spondylitis (AS). In this study, we performed non-targeted fecal metabolomics in AS in order to discover the microbiome–metabolome interface in AS.
Yupeng Lai, Yupeng Lai, Wenli Tang, Xiao Luo, Huihui Zheng, Yanpeng Zhang, Meiying Wang, Guangchuang Yu, Min Yang   +8 more
doaj   +2 more sources

A Pharmacometric Workflow for Resolving Model Instability in Model Use-Reuse Settings. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT The development of fit‐for‐purpose pharmacokinetic‐pharmacodynamic (PKPD) models based on clinical and pre‐clinical data is a critically important process in model informed drug development. This process is often hampered by modeling stability issues that are often multifactorial in nature and difficult to overcome, leading to protracted model
Duffull SB, Wright DFB, Zhu X, Liu X, Abulfathi A, Hishe H.   +5 more
europepmc   +2 more sources

Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates [PDF]

, 2021
Background: Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE).
Bakkali, Loubna el, Klebermass-Schrehof, Katrin, Schroth, Michael, Nijstad, A. Laura, Stiris, Tom, Bassler, Dirk, Benders, Manon J. N. L., Guimaraes, Hercilia, Chu, Wan-Yu, Mazela, Jan, Franz, Axel R., Maiwald, Christian A., Mauro, Isabella, van Weissenbruch, Mirjam M., Poets, Christian F., van Bel, Frank, Hagen, Anja, Rüdiger, Mario, Vanhatalo, Sampsa, Jacobs, Yannique, Huitema, Alwin D. R., Metsäranta, Marjo, Allegaert, Karel, Vento, Maximo, Dorlo, Thomas P. C., Annink, Kim V., Naulaers, Gunnar   +26 more
core   +3 more sources

Reduced Serum Urate Concentrations Despite Unchanged Allopurinol Dosing in Gout Patients Commenced on Dialysis: A Retrospective Chart Review [PDF]

Nephrology (Carlton)
The study investigated allopurinol dosing practises and serum urate concentrations in gout patients with kidney failure following commencing dialysis. Results showed allopurinol dose was most commonly 100 mg, unadjusted upon commencing dialysis. However, serum urate concentrations significantly declined as patients commenced dialysis with more than 50%
Kamel N, Castelino R, Wright D, Sud K, Tarafdar S, Hughes S, Stocker S.   +6 more
europepmc   +2 more sources

Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture. [PDF]

Nucleic Acids Res
Riboswitch-mediated control of gene expression without the interference of potentially immunogenic proteins is a promising approach for the development of tailor-made tools for biological research and the advancement of gene therapies.
Hedwig V, Spöring M, Ottlinger J, Köse S, Nar H, Schnapp G, Gottschling D, Klein H, Aspnes G, Klugmann M, Hartig JS.   +10 more
europepmc   +2 more sources

An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites

Clinical and Translational Science, 2022
ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid‐lowering ...
Marc‐Olivier Pilon, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus   +11 more
doaj   +1 more source