Results 41 to 50 of about 524 (148)

Does Allopurinol Prevent Post Endoscopic Retrograde Cholangio- Pancreatography Pancreatitis? A Randomized Double Blind Trial [PDF]

Acta Medica Iranica, 2011
Post endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a frequent complication either for diagnosis or treatment of pancreatobiliary diseases.
Mohammad Abbasinazari, Amir Houshang Mohammad Alizadeh, Kamyar Moshiri, Mohammad Amin Pourhoseingholi, Mohammad Reza Zali   +4 more
doaj   +1 more source

Impairment by Hypoxia or Hypoxia/Reoxygenation of Nitric Oxide–Mediated Relaxation in Isolated Monkey Coronary Artery: the Role of Intracellular Superoxide

Journal of Pharmacological Sciences, 2011
.: To investigate the effect of hypoxia or hypoxia/reoxygenation on vascular smooth muscle function, mechanical response of monkey coronary artery without endothelium was studied under normoxia, hypoxia, and hypoxia/reoxygenation.
Masashi Tawa, Kohei Yamamizu, Ayman Geddawy, Takashi Shimosato, Takeshi Imamura, Kazuhide Ayajiki, Tomio Okamura   +6 more
doaj   +1 more source

Comparative Study of the Lipophilicity of Selected Anti-Androgenic and Blood Uric Acid Lowering Compounds

Molecules, 2022
This study aimed to evaluate the lipophilicity of a series substances lowering the concentration of uric acid in blood and anti-androgen drugs by thin-layer chromatography in reversed-phase systems (RP-TLC, RP-HPTLC) and computational methods.
Dawid Wardecki, Małgorzata Dołowy, Katarzyna Bober-Majnusz, Josef Jampilek   +3 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

The Safety of Treating Women With Inflammatory Bowel Disease With Allopurinol and Low‐Dose Thiopurine During Pregnancy: A Single‐Center Experience

JCC Plus, Volume 1, Issue 4, July 2026.
ABSTRACT Background Low‐dose thiopurine therapy in combination with allopurinol (LD‐THIO/ALLO) is a widely used treatment for inflammatory bowel disease (IBD). However, little is known about the effects of in utero exposure to this combination on pregnancy and birth outcomes.
Kavitha Sivananthan, Signe Wildt, Marianne Kiszka‐Kanowitz, Gitte Pedersen, Ida Vind, Inge Nordgaard‐Lassen, Andreas Munk Petersen, Johan Burisch, Helle Kristensen, Klaus Theede   +9 more
wiley   +1 more source

Response to Allopurinol and Febuxostat According to the Fractional Excretion of Urate in Men With Gout

Arthritis Care &Research, Volume 78, Issue 6, Page 781-787, June 2026.
Objective Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of uric acid (FEUA) also modulates this response and relates to oxypurinol concentrations.
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Prediction of ADMET, molecular docking, DFT, and QSPR of potential phytoconstituents from Ambrosia maritima L. targeting xanthine oxidase [PDF]

Pharmacia
This study aimed to evaluate the xanthine oxidase (XO) inhibitory activities of seven compounds identified in the potent antioxidant ethyl acetate fraction of Ambrosia maritima L. using various computational tools.
Wadah Osman, Shaza Shantier, Nazik Mohamed, Sahar Abdalla, Mona Mohamed, Yunsua Umar, Asmaa E. Sherif, Khaled M. Elamin, Ahmed Ashour   +8 more
doaj   +3 more sources

Phloroglucinol Derivatives from Dryopteris crassirhizoma as Potent Xanthine Oxidase Inhibitors

Molecules, 2020
Dryopteris crassirhizoma rhizomes are used as a traditional medicine in Asia. The EtOAc extract of these roots has shown potent xanthine oxidase (XO) inhibitory activity. However, the main phloroglucinols in D.
Heung Joo Yuk, Ji-Yul Kim, Yoon-Young Sung, Dong-Seon Kim   +3 more
doaj   +1 more source

Spatial Variability in Trace Organic Compound Reactivity During Urban River Infiltration Into an Alluvial Aquifer

Water Resources Research, Volume 62, Issue 5, May 2026.
Abstract Trace organic compounds (TrOCs) in lotic systems pose risks for ecosystem and human health. TrOCs can enter groundwater along losing river sections, yet little is known about the spatial extent of infiltration zones and the biogeochemical factors controlling the spatial variability of TrOC reactivity and removal, particularly along river‐to ...
Jonas L. Schaper, Olaf A. Cirpka, Malte Posselt, Joerg Lewandowski, Karin Meinikmann, Anke Putschew, Christiane Zarfl   +6 more
wiley   +1 more source

Time-dependent biological responses of juvenile yellow perch (Perca flavescens) exposed in situ to a major urban effluent

Ecotoxicology and Environmental Safety, 2021
Municipal wastewater treatment plant (WWTP) effluents are significant sources of organic and inorganic pollutants to aquatic ecosystems. Several studies have shown that the health of aquatic organisms can be adversely impacted following exposure to these
Michel A. Defo, Laurie Mercier, Conrad Beauvais, Robert B. Brua, Gerald Tétreault, Anthony Fontaine, Patrice Couture, Jonathan Verreault, Magali Houde   +8 more
doaj   +1 more source