Results 41 to 50 of about 1,503 (160)

Prediction of ADMET, molecular docking, DFT, and QSPR of potential phytoconstituents from Ambrosia maritima L. targeting xanthine oxidase [PDF]

Pharmacia
This study aimed to evaluate the xanthine oxidase (XO) inhibitory activities of seven compounds identified in the potent antioxidant ethyl acetate fraction of Ambrosia maritima L. using various computational tools.
Wadah Osman, Shaza Shantier, Nazik Mohamed, Sahar Abdalla, Mona Mohamed, Yunsua Umar, Asmaa E. Sherif, Khaled M. Elamin, Ahmed Ashour   +8 more
doaj   +3 more sources

Phloroglucinol Derivatives from Dryopteris crassirhizoma as Potent Xanthine Oxidase Inhibitors

Molecules, 2020
Dryopteris crassirhizoma rhizomes are used as a traditional medicine in Asia. The EtOAc extract of these roots has shown potent xanthine oxidase (XO) inhibitory activity. However, the main phloroglucinols in D.
Heung Joo Yuk, Ji-Yul Kim, Yoon-Young Sung, Dong-Seon Kim   +3 more
doaj   +1 more source

Time-dependent biological responses of juvenile yellow perch (Perca flavescens) exposed in situ to a major urban effluent

Ecotoxicology and Environmental Safety, 2021
Municipal wastewater treatment plant (WWTP) effluents are significant sources of organic and inorganic pollutants to aquatic ecosystems. Several studies have shown that the health of aquatic organisms can be adversely impacted following exposure to these
Michel A. Defo, Laurie Mercier, Conrad Beauvais, Robert B. Brua, Gerald Tétreault, Anthony Fontaine, Patrice Couture, Jonathan Verreault, Magali Houde   +8 more
doaj   +1 more source

Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4‐Linked Hereditary Spastic Paraplegia—A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Graphical representation of spasticity and medication changes. (A) Temporal course of lower limb spasticity measured by MAS scores. Following initiation of allopurinol 300 mg daily at baseline (red dashed line), there was a rapid and sustained improvement in spasticity from severe (MAS = 4) to mild (MAS = 1.8) over 12 months of follow‐up, represented ...
Ziad W. Elmezayen, Hossam Salameh, Asem Afana, Anwar Zahran   +3 more
wiley   +1 more source

Mechanism for the Increased Permeability in Endothelial Monolayers Induced by Elastase

Mediators of Inflammation, 1994
The aim of this study was to investigate the mechanism for the increase in endothelial permeability induced by human neutrophil elastase (HNE). Pretreatment of bovine pulmonary artery endothelial cells (BPAEC) with HNE(0-30 μg/ml) for 1 h produced a ...
N. Suzuki, Y. Ishii, S. Kitamura
doaj   +1 more source

Allopurinol Treatment Improves Cognitive Skills, Adaptive Behavior, and Biochemical Markers in Young Patients With Adenylosuccinate Lyase Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Adenylosuccinate lyase deficiency (ADSLD) is a rare neurological disorder characterized by psychomotor retardation, autistic behaviors, and seizures, with no specific treatment available. ADSL catalyzes the transformation of succinylaminoimidazole carboxamide ribotide (SAICAr) to AICAR, and succinyl‐AMP (S‐AMP) to AMP.
Bérangère Rousselot‐Pailley, Michaela Semeraro, Fabienne Marquant, Laurence Robel, Cyril Gitiaux, Anna Kaminska, Fanny Mochel, Prissile Bakouboula, Caroline Elie, Carole Hennequin, Irène Ceballos‐Picot, Sylvia Sanquer, Pascale de Lonlay   +12 more
wiley   +1 more source

Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data

Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 425-441, October 2025.
ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval, Richard Judson, Julia E. Rager   +2 more
wiley   +1 more source

Metabolic factors determining the effectiveness of hypouricemic treatment of gouty arthritis

Bolʹ, Sustavy, Pozvonočnik, 2018
Background. The treatment of some forms of arti­cular pathology with gout remains insufficiently effective, and often it’s impossible to achieve normal indicators of uricemia on the background of uric acid-normalizing medicines.
O.V. Syniachenko, D.M. Fedorov, M.V. Yermolaieva, V.V. Pylypenko   +3 more
doaj   +1 more source

Oxipurinol

Drugs in R & D, 2004
Oxipurinol [alloxanthine, Oxyprim, oxypurinol] is the active metabolite of the only commercially available xanthine oxidase inhibitor, allopurinol. Oxipurinol is also a xanthine oxidase inhibitor. Oxipurinol is currently being developed by Cardiome Pharma.
openaire   +2 more sources

2024 Update of Chinese Guidelines for Diagnosis and Treatment of Hyperuricemia and Gout Part I: Recommendations for General Patients

International Journal of Rheumatic Diseases, Volume 28, Issue 7, July 2025.
ABSTRACT Background In 2018, the Chinese Society of Endocrinology developed the “Chinese guideline for diagnosis and treatment of hyperuricemia and gout (2019)”. Over the past 5 years, clinical and experimental research has expanded our knowledge of gout, resulting in novel diagnostic and therapeutic approaches.
Mingshu Sun, Zhaohui Lyu, Can Wang, Yan Li, Dongbao Zhao, Xingwu Ran, Haibing Chen, Benli Su, Xiangyun Chang, Ping Liu, Dewen Yan, Xiuyun Jiang, Kang Chen, Jiaqing Shao, Xiaochun Teng, Yongli Yao, Yuming Li, Ying Chen, Jidong Cheng, Zhifeng Cheng, Zhen Liu, Fengjing Liu, Xinyu Li, Huiyong Yin, Chao Liu, Hsiao‐Yi Lin, Yaolong Chen, Wen‐Chan Tsai, Ronald M. L. Yip, Changgui Li, Jiajun Zhao   +30 more
wiley   +1 more source