Results 51 to 60 of about 1,837 (187)
Some Adverse Reactions to Allopurinol May Be Mediated by Lymphocyte-Reactivity to Oxypurinol
, 1988 Six of 9 patients with previously documented adverse reactions to allopurinol exhibited transformation of their peripheral blood lymphocytes when these were exposed in vitro to the allopurinol metabolite, oxypurinol.
Hazelton, RA +5 more
core +1 more source
Ecotoxicology and Environmental Safety, 2021 Municipal wastewater treatment plant (WWTP) effluents are significant sources of organic and inorganic pollutants to aquatic ecosystems. Several studies have shown that the health of aquatic organisms can be adversely impacted following exposure to these
Michel A. Defo +8 more
doaj +1 more source
Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 425-441, October 2025.ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval +2 more
wiley +1 more source
Mechanism for the Increased Permeability in Endothelial Monolayers Induced by Elastase
Mediators of Inflammation, 1994 The aim of this study was to investigate the mechanism for the increase in endothelial permeability induced by human neutrophil elastase (HNE). Pretreatment of bovine pulmonary artery endothelial cells (BPAEC) with HNE(0-30 μg/ml) for 1 h produced a ...
N. Suzuki, Y. Ishii, S. Kitamura
doaj +1 more source
International Journal of Rheumatic Diseases, Volume 28, Issue 7, July 2025.ABSTRACT Background In 2018, the Chinese Society of Endocrinology developed the “Chinese guideline for diagnosis and treatment of hyperuricemia and gout (2019)”. Over the past 5 years, clinical and experimental research has expanded our knowledge of gout, resulting in novel diagnostic and therapeutic approaches.
Mingshu Sun +30 more
wiley +1 more source
Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates [PDF]
, 2022 BACKGROUND: Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE).
ALBINO Study Group
core
Metabolic factors determining the effectiveness of hypouricemic treatment of gouty arthritis
Bolʹ, Sustavy, Pozvonočnik, 2018 Background. The treatment of some forms of articular pathology with gout remains insufficiently effective, and often it’s impossible to achieve normal indicators of uricemia on the background of uric acid-normalizing medicines.
O.V. Syniachenko +3 more
doaj +1 more source
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Its progressively expanding, fluid‐filled renal cysts eventually lead to end‐stage renal disease. Despite the relatively high prevalence, treatment options are currently limited to a single drug approved by the FDA and EMA.
Alina Meyer +9 more
wiley +1 more source
Drugs in R & D, 2004 Oxipurinol [alloxanthine, Oxyprim, oxypurinol] is the active metabolite of the only commercially available xanthine oxidase inhibitor, allopurinol. Oxipurinol is also a xanthine oxidase inhibitor. Oxipurinol is currently being developed by Cardiome Pharma.
openaire +2 more sources
, 2003 Objective: Xanthine oxidase (XO) inhibitors enhance myofilament Ca2+ responsiveness of normal rat myocardium. We examined whether this inotropic action is preserved or magnified in failing rat myocardium and whether the magnitude of this effect ...
McCune, S. +4 more
core +1 more source