Results 51 to 60 of about 1,503 (160)

A Patient‐Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Its progressively expanding, fluid‐filled renal cysts eventually lead to end‐stage renal disease. Despite the relatively high prevalence, treatment options are currently limited to a single drug approved by the FDA and EMA.
Alina Meyer, Bola Khalil, Margarita Iljin, Hester Bange, Leo S. Price, Natalia Dyubankova, Gerard J. P. van Westen, Herman van Vlijmen, Dorien J. M. Peters, Per Artursson   +9 more
wiley   +1 more source

Exploring recent advances in drugs severe cutaneous adverse reactions immunopathology

Allergy, Volume 80, Issue 1, Page 47-62, January 2025.
Abstract Severe cutaneous adverse reactions to drugs (SCARs) are rare but life‐threatening delayed allergies. While they primarily affect the skin, they can also affect internal organs. Accordingly, they present with diverse clinical symptoms that vary not only between SCARs subtypes but also among patients.
Romane Cadot, Perrine Gery, Vanina Lenief, Jean‐François Nicolas, Marc Vocanson, Marie Tauber   +5 more
wiley   +1 more source

Evaluation of Xanthine Oxidase Inhibitors Febuxostat and Allopurinol on Kidney Dysfunction and Histological Damage in Two‐Kidney, One‐Clip (2K1C) Rats

Scientifica, Volume 2025, Issue 1, 2025.
In chronic kidney disease (CKD), hyperuricemia is a common phenomenon, presumably due to reduced renal clearance of uric acid. This study investigated the effect of xanthine oxidase (XO) inhibitors allopurinol and febuxostat to prevent oxidative stress in the kidney of two‐kidney, one‐clip (2K1C) rats.
Asif Ul Haque Shuvo, Mirza Alimullah, Ishrat Jahan, Kaniz Fatima Mitu, Md Junaeid Rahman, Kazi Akramuddaula, Ferdous Khan, Pritesh Ranjan Dash, Nusrat Subhan, Md Ashraful Alam, Sukhamoy Gorai   +10 more
wiley   +1 more source

Identifying biochemical changes in the kidney using proton nuclear magnetic resonance in an adenine diet chronic kidney disease mouse model

NMR in Biomedicine, Volume 37, Issue 12, December 2024.
A whole tissue metabonomic and gene expression analysis of diseased kidney tissue used an adenine diet‐induced chronic kidney disease mouse model. Evidence observed of decreased utilisation of fatty acid oxidation and increased reliance of glycolysis by the cell of the kidney under disease conditions.
Tyrone L. R. Humphries, Glenda C. Gobe, Aaron J. Urquhart, Robert J. Ellis, Graham J. Galloway, David A. Vesey, Ross S. Francis   +6 more
wiley   +1 more source

AOP report: Development of an adverse outcome pathway for deposition of energy leading to abnormal vascular remodeling

Environmental and Molecular Mutagenesis, Volume 65, Issue S3, Page 4-30, October 2024.
Abstract Cardiovascular diseases (CVDs) are complex, encompassing many types of heart pathophysiologies and associated etiologies. Radiotherapy studies have shown that fractionated radiation exposure at high doses (3–17 Gy) to the heart increases the incidence of CVD.
Tatiana Kozbenko, Nadine Adam, Veronica S. Grybas, Benjamin J. Smith, Dalya Alomar, Robyn Hocking, Janna Abdelaziz, Amanda Pace, Marjan Boerma, Omid Azimzadeh, Steve Blattnig, Nobuyuki Hamada, Carole Yauk, Ruth Wilkins, Vinita Chauhan   +14 more
wiley   +1 more source

Biological biomarkers of oral cancer

Periodontology 2000, Volume 96, Issue 1, Page 250-280, October 2024.
Abstract The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant ...
Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo‐Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton‐That, Cun‐Yu Wang, Yvonne L. Kapila   +9 more
wiley   +1 more source

Multicentre study and systematic review: Allopurinol exposure during pregnancy

Alimentary Pharmacology &Therapeutics, Volume 60, Issue 4, Page 503-518, August 2024.
Despite being the largest study to date, evidence regarding the risk of adverse pregnancy outcomes after allopurinol exposure remains limited. Interestingly, both our multicentre study and systematic review sub‐analysis in IBD‐pregnancies revealed a relatively low risk of congenital malformations after foetal exposure to a low dose of allopurinol in ...
Femke Crouwel, Melek Simsek, Marjon A. de Boer, Dirk P. van Asseldonk, Abha Bhalla, Angelique L. M. Weusthuis, Lennard P. L. Gilissen, Robert J. Verburg, Wout G. N. Mares, Bindia Jharap, Johan P. Kuijvenhoven, Bas Oldenburg, Hans J. C. Buiter, Mette Julsgaard, Nanne K. de Boer   +14 more
wiley   +1 more source

Research on the effects of intestinal FXR agonists and antibiotics on the regulation of red kidney bean polysaccharides in the liver metabolism in mice with type 2 diabetes

eFood, Volume 5, Issue 3, June 2024.
In a mouse model of type 2 diabetes, we used antibiotics and the intestinal fxr agonist Fexaramine to interfere with the intestinal flora and activate the intestinal fxr to investigate whether red kidney bean polysaccharides (RKB) could still have a protective effect on the hepatic function of diabetic mice under the premise that the intestinal flora ...
Yunhui Zhang, Caili Qi, Xingguo Li, Mengyuan Geng, Honglin Lan, Yifang Wei, Denglin Luo, Zhouya Bai, Jinying Guo, Sihai Han   +9 more
wiley   +1 more source

How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

Arthritis Research & Therapy, 2018
Objective Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU).
Lisa K. Stamp, Peter T. Chapman, Murray L. Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth   +7 more
doaj   +1 more source

The development and evaluation of dose‐prediction tools for allopurinol therapy (Easy‐Allo tools)

British Journal of Clinical Pharmacology, Volume 90, Issue 5, Page 1268-1279, May 2024.
Abstract Aims Dose escalation at the initiation of allopurinol therapy can be protracted and resource intensive. Tools to predict the allopurinol doses required to achieve target serum urate concentrations would facilitate the implementation of more efficient dose‐escalation strategies.
Daniel F. B. Wright, Hailemichael Z. Hishe, Sophie L. Stocker, Nicola Dalbeth, Anne Horne, Jill Drake, Janine Haslett, Amanda J. Phipps‐Green, Tony R. Merriman, Lisa K. Stamp   +9 more
wiley   +1 more source