Results 61 to 70 of about 524 (148)
International Journal of Rheumatic Diseases, Volume 28, Issue 7, July 2025.ABSTRACT Background In 2018, the Chinese Society of Endocrinology developed the “Chinese guideline for diagnosis and treatment of hyperuricemia and gout (2019)”. Over the past 5 years, clinical and experimental research has expanded our knowledge of gout, resulting in novel diagnostic and therapeutic approaches.
Mingshu Sun +30 more
wiley +1 more source
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Its progressively expanding, fluid‐filled renal cysts eventually lead to end‐stage renal disease. Despite the relatively high prevalence, treatment options are currently limited to a single drug approved by the FDA and EMA.
Alina Hartwig +9 more
wiley +1 more source
Hámörkun á UPLC-MS/MS magngreiningaraðferð fyrir 2,8-díhýdroxýadenín og oxypurinol
, 2016 Background: Adenine phosporibosyltransferase (APRT) deficiency is a metabolic disorder which is the cause of adenine oxidation to 2,8-dihydroxyadenine (DHA) instead of normal conversion to AMP.
Ómar Rafn Stefánsson 1985-
core +1 more source
Oxypurinol-Specific T Cells Possess Preferential TCR Clonotypes and Express Granulysin in Allopurinol-Induced Severe Cutaneous Adverse Reactions [PDF]
, 2015 Allopurinol, a first-line drug for treating gout and hyperuricemia, is one of the leading causes of severe cutaneous adverse reactions (SCARs). To investigate the molecular mechanism of allopurinol-induced SCAR, we enrolled 21 patients (13 Stevens ...
Chu, Mu-Tzu +7 more
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Exploring recent advances in drugs severe cutaneous adverse reactions immunopathology
Allergy, Volume 80, Issue 1, Page 47-62, January 2025.Abstract Severe cutaneous adverse reactions to drugs (SCARs) are rare but life‐threatening delayed allergies. While they primarily affect the skin, they can also affect internal organs. Accordingly, they present with diverse clinical symptoms that vary not only between SCARs subtypes but also among patients.
Romane Cadot +5 more
wiley +1 more source
, 1990 Allopurinol and its metabolite oxypurinol inhibited basal oxidation of ascorbate and exerted comparable concentration-dependent inhibitory effects on the oxidation of ascorbate catalysed by cupric ion, but the stimulation produced by ferric ion was ...
Kam Ming Ko, Ming Ko, Godin, David V.
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Scientifica, Volume 2025, Issue 1, 2025.In chronic kidney disease (CKD), hyperuricemia is a common phenomenon, presumably due to reduced renal clearance of uric acid. This study investigated the effect of xanthine oxidase (XO) inhibitors allopurinol and febuxostat to prevent oxidative stress in the kidney of two‐kidney, one‐clip (2K1C) rats.
Asif Ul Haque Shuvo +10 more
wiley +1 more source
, 2003 Objective: Xanthine oxidase (XO) inhibitors enhance myofilament Ca2+ responsiveness of normal rat myocardium. We examined whether this inotropic action is preserved or magnified in failing rat myocardium and whether the magnitude of this effect ...
McCune, S. +4 more
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NMR in Biomedicine, Volume 37, Issue 12, December 2024.A whole tissue metabonomic and gene expression analysis of diseased kidney tissue used an adenine diet‐induced chronic kidney disease mouse model. Evidence observed of decreased utilisation of fatty acid oxidation and increased reliance of glycolysis by the cell of the kidney under disease conditions.
Tyrone L. R. Humphries +6 more
wiley +1 more source
The xanthine oxidase inhibitor oxypurinol does not limit infarct size in a canine model of 40 minutes of ischemia with reperfusion [PDF]
, 1988 Free radicals such as superoxide (O2−) produced by xanthine oxidase might cause cell death during reperfusion after myocardial ischemia. The effect of the xanthine oxidase inhibitor allopurinol on infarct size in ischemiareperfusion models has been ...
Jennings, Robert B +4 more
core +1 more source