Results 61 to 70 of about 1,503 (160)

Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials

BMC Cardiovascular Disorders, 2018
Background Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from ...
Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d’Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein, Guilherme Gomes Dias Campos   +8 more
doaj   +1 more source

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Journal of Translational Medicine
Background Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, and coxsackievirus B3.
JinFang Hao, Xiaoyan Zhang, Ruixian Hu, Xiufeng Lu, Hui Wang, Yuanhong Li, Kai Cheng, Qingshan Li   +7 more
doaj   +1 more source

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Clinical and pathogenetic importance of hormonal natriuretic peptides in gout

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. In addition to purine metabolism disorders, systems of pro-inflammatory cytokines, matrix metalloproteinases and eicosanoids, various medium molecular weight compounds can participate in the pathogenesis of gout, including natriuretic ...
O.V. Syniachenko, D.M. Fedorov, M.V. Yermolaieva, V.V. Pylypenko   +3 more
doaj   +1 more source

Comparative assessment of primary and paraneoplastic gout in lung cancer

Zaporožskij Medicinskij Žurnal, 2018
Introduction. Lung cancer (LС) is the most common cause of the so-called paraneoplastic syndrome (PNPS) development, caused by the complex immunoinflammatory, degenerative and vascular distant changes.
O. V. Syniachenko, Yu. V. Dumanskyi, Ye. D. Yehudina, O. Ye. Chernyshova, P. A. Stepko, D. M. Fedorov   +5 more
doaj   +1 more source

Comparison of Aroma and Taste Profiles of Kiwi Wine Fermented with/without Peel by Combining Intelligent Sensory, Gas Chromatography-Mass Spectrometry, and Proton Nuclear Magnetic Resonance

Foods
Kiwi wine (KW) is tipically made by fermenting juice from peeled kiwifruit, resulting in the disposal of peel and pomace as by-products. However, the peel contains various beneficial compounds, like phenols and flavonoids.
Bingde Zhou, Xiaochen Liu, Qiuyu Lan, Fang Wan, Zhibo Yang, Xin Nie, Zijian Cai, Bin Hu, Junni Tang, Chenglin Zhu, Luca Laghi   +10 more
doaj   +1 more source

Allopurinol-Induced DRESS Syndrome in Patients with Pre-Existing Chronic Kidney Disease: A Case Report and Comprehensive Literature Review

Case Reports in Dermatology
Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction that can be triggered by allopurinol, with increased risk in patients with chronic kidney ...
Ashraf Ahmed, Alaa Abdelhamid, Hidaya Al-Tamimi, Raghad Elashie, Elhassan Mahmoud, Ali Ibrahim Rahil   +5 more
doaj   +1 more source

The role of urate and xanthine oxidase in vascular oxidative stress: future directions

Therapeutics and Clinical Risk Management, 2009
Jacob George, Allan StruthersDivision of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UKAbstract: Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction.
Jacob George, Allan Struthers
doaj  

An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia

Vascular Health and Risk Management, 2017
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Abstract: Several studies suggest that chronic hyperuricemia, the main ...
Bove M, Cicero AFG, Veronesi M, Borghi C
doaj  

Effects of allopurinol and of oxypurinol on turkey liver xanthine dehydrogenase [PDF]

FEBS Letters, 1978
Ní Fhaoláin, Íde, Coughlan, Michael P.   +1 more
openaire   +2 more sources