Results 71 to 80 of about 524 (148)
Environmental and Molecular Mutagenesis, Volume 65, Issue S3, Page 4-30, October 2024.Abstract Cardiovascular diseases (CVDs) are complex, encompassing many types of heart pathophysiologies and associated etiologies. Radiotherapy studies have shown that fractionated radiation exposure at high doses (3–17 Gy) to the heart increases the incidence of CVD.
Tatiana Kozbenko +14 more
wiley +1 more source
Biological biomarkers of oral cancer
Periodontology 2000, Volume 96, Issue 1, Page 250-280, October 2024.Abstract The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant ...
Allan Radaic +9 more
wiley +1 more source
Multicentre study and systematic review: Allopurinol exposure during pregnancy
Alimentary Pharmacology &Therapeutics, Volume 60, Issue 4, Page 503-518, August 2024.Despite being the largest study to date, evidence regarding the risk of adverse pregnancy outcomes after allopurinol exposure remains limited. Interestingly, both our multicentre study and systematic review sub‐analysis in IBD‐pregnancies revealed a relatively low risk of congenital malformations after foetal exposure to a low dose of allopurinol in ...
Femke Crouwel +14 more
wiley +1 more source
BACKGROUND: The aim of this study was to investigate whether allopurinol and oxypurinol treatment could mitigate oxidative stress and germ cell apoptosis in testicular ischemia-reper fusion (IR) injury.
KART, Yeliz +4 more
core +1 more source
Arthritis Research & Therapy, 2018 Objective Allopurinol dosing has frequently been limited based on creatinine clearance (CrCL), resulting in failure to achieve target serum urate (SU).
Lisa K. Stamp +7 more
doaj +1 more source
eFood, Volume 5, Issue 3, June 2024.In a mouse model of type 2 diabetes, we used antibiotics and the intestinal fxr agonist Fexaramine to interfere with the intestinal flora and activate the intestinal fxr to investigate whether red kidney bean polysaccharides (RKB) could still have a protective effect on the hepatic function of diabetic mice under the premise that the intestinal flora ...
Yunhui Zhang +9 more
wiley +1 more source
, 2014 Allopurinol and, and its active metabolite, oxypurinol are widely used in the treatment of gout and hyperuricemia. They act by inhibiting xanthine oxidase an enzyme in the purine degradation pathway that converts xanthine to uric acid.
Arnett, Timothy +3 more
core +1 more source
, 1999 The purpose of the present study was to determine whether it is possible to alter the development of fatigue and ablate free radical-mediated lipid peroxidation of the diaphragm during loaded breathing by administering oxypurinol, a xanthine oxidase ...
A. DiMarco +4 more
core +1 more source
Oxypurinol limits myocardial stunning but does not reduce infarct size after reperfusion.
, 1987 To explore the role of oxygen free radicals produced by the xanthine oxidase pathway on infarct size and left ventricular function, the effect of oxypurinol, an active metabolite of allopurinol and a potent noncompetitive inhibitor of xanthine oxidase ...
D W Puett +6 more
core +1 more source
Prevention of reperfusion injury in ischemic-reperfused hearts by oxypurinol and allopurinol
Transplant International, 1989 We investigated the effects of the xanthine oxidase inhibitor allopurinol and its metabolite oxypurinol on isolated rabbit hearts. To assess the potential role of these drugs in preventing reperfusion injury, hearts were perfused using Langendorff techniques, held globally ischemic for 3 h at 15 degrees C, and then reperfused.
L, LoBalsamo +3 more
openaire +2 more sources