Results 91 to 100 of about 524 (148)

Chemo- and Regioselective Functionalization of Uracil Derivatives. Applications to the Synthesis of Oxypurinol and Emivirine

, 2016
A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo- and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such
Paul Knochel (1376235), Nadège Boudet (2441230)   +1 more
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Febuxostat suppresses LPS-induced ROS formation and MCP-1 production more effectively than allopurinol and oxypurinol.

, 2013
(A) ROS was produced by buttermilk XO (10 mU/mL) and xanthine (100 µM) in the absence or presence of febuxostat (Feb, 100 nM), allopurinol (Allo, 100 µM) or oxypurinol (Oxy, 100 µM), and detected by DCF ROS indicator. Fluorescence was measured.
Syunsuke Tsujimoto (462920), Nathalie Busso (8780), Alexander So (8781), Annette Ives (218882), Mizuho Tamura (462921), Yoshihiro Yamanaka (462922), Johji Nomura (462919)   +6 more
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Influence of xanthine oxidase inhibitors allopurinol and oxypurinol on the course of body weight, on body composition and spontaneous activity in a rat model of tumour cachexia

, 2010
Die zur Entstehung einer Kachexie bei Tumorerkrankung führenden Signalwege sind noch nicht vollständig verstanden. In diesem Zusammenhang wurde eine erhöhte Aktivität des Enzyms Xanthinoxidase berichtet, welche über eine Steigerung der Produktion ...
Hartmann, Kai
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Concentration of thiopurine metabolites in (A) HEK293 after incubation with 6MP and 6MP+AP, and in (B) HEK293 cells after incubation with 6MP and 6MP+oxypurinol.

, 2017
Concentration of thiopurine metabolites in (A) HEK293 cells incubated with 6MP (3 μM) or the combination 6MP (3 μM) +AP (100 μM) for 73 h. (B) Concentration of thiopurine metabolites in HEK293 cells incubated with 6MP (3 μM) or the combination 6MP (3 μM)
Jan Söderman (380629), Sofie Haglund (380627), Sven Almer (8167), Svante Vikingsson (3826924)   +3 more
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Einfluss von Oxypurinol auf die koronare und periphere Endothelfunktion von Patienten mit koronarer Herzerkrankung

, 2008
Es wird der Einfluss einer intravenösen Gabe von Oxypurinol, einem Inhibitor der Xanthinoxidase, auf die Endothelfunktion bei Patienten mit koronarer Herzerkrankung als einer Manifestation der Atherosklerose untersucht. Als Indikator der Endothelfunktion
Koss, Klaus Gustav
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Effects of allopurinol and of oxypurinol on turkey liver xanthine dehydrogenase [PDF]

FEBS Letters, 1978
Ní Fhaoláin, Íde, Coughlan, Michael P.   +1 more
openaire   +2 more sources

A Genome-Wide Association Study of Oxypurinol Concentrations in Patients Treated with Allopurinol

Cohort studies have identified several genetic determinants that could predict the clinical response to allopurinol. However, they have not been commonly used for genome-wide investigations to identify genetic determinants on allopurinol metabolism and ...
Marc-Olivier Pilon, Diane Valois, Essaïd Oussaïd, Marie-Josée Gaulin, Louis-Philippe Lemieux Perreault, Ian Mongrain, Jean-Claude Tardif, Maxime Meloche, Jean-Lucien Rouleau, Simon de Denus, Sylvie Provost, David Busseuil, Marie-Pierre Dubé, Grégoire Leclair, Isabelle St-Jean, Martin Jutras   +15 more
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Simultaneous determination of acetaminophen, oxypurinol and uric acid in the presence of ascorbic acid with microchip

, 2010
碩士本研究將PDMS (polydimethylsiloxane)微晶片電泳與電化學偵測系統結合。於微流道晶片所使用的材質中，PDMS是目前被廣為應用的高分子聚合物之一，其具有低成本、透光性佳且有良好的機械性與可塑性等特性，然而運用於微晶片電泳中，其電滲透流不穩定以及親水性不佳等缺點，是過去文獻中不斷研究改善的部分；相較於常見的PDMS表面改質方式，如共價鍵修飾、電漿處理、動態塗佈與化學氣相沉積等，本研究以摻雜PU (Polyurethane) 的修飾方式，來達到較為簡易、快速且穩定的改質的目的 ...
邱怡華; Chiu, Yi-hua
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Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure.

, 2004
Oxypurinol, the active metabolite of allopurinol and a potent xanthine oxidase inhibitor (XOI), is under evaluation as a novel agent for the treatment of congestive heart failure (HF).
Brown, Joanne, BSc, Mann, Douglas L, MD, Givertz, Michael M, MD, Hare, Joshua M, MD, Freudenberger, Ronald S, MD, Moore, Alan, Colucci, Wilson S, MD, Schwarz, Richard P, PhD   +7 more
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Deneysel testis torsiyonu modelinde allopurinol ve oksipurinol tedavisinin apoptozise etkisi = Effect of allopurinol and oxypurinol treatment on apoptosis in experimental testicular torsion model /

Amaç: Testis torsiyonu testis kaybına neden olabilen ürolojik acil bir durumdur. Cerrahi detorsiyon sonrası gelişen reperfüzyon hasarı daha fazla doku hasarına yol açarak testiküler fonksiyon kaybına ve infertiliteye neden olabilir.
Duman, Levent, 1975- 222762 thesis advisor, Süleyman Demirel Üniversitesi. Tıp Fakültesi. Çocuk Cerrahisi Anabilim Dalı. 18397 issuing body, Bilaloğlu, Emine, 1990- 262525 author   +2 more
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