Results 91 to 100 of about 1,837 (187)

Allopurinol-Induced DRESS Syndrome in Patients with Pre-Existing Chronic Kidney Disease: A Case Report and Comprehensive Literature Review

Case Reports in Dermatology
Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction that can be triggered by allopurinol, with increased risk in patients with chronic kidney ...
Ashraf Ahmed, Alaa Abdelhamid, Hidaya Al-Tamimi, Raghad Elashie, Elhassan Mahmoud, Ali Ibrahim Rahil   +5 more
doaj   +1 more source

Concentration of thiopurine metabolites in (A) HEK293 after incubation with 6MP and 6MP+AP, and in (B) HEK293 cells after incubation with 6MP and 6MP+oxypurinol.

, 2017
Concentration of thiopurine metabolites in (A) HEK293 cells incubated with 6MP (3 μM) or the combination 6MP (3 μM) +AP (100 μM) for 73 h. (B) Concentration of thiopurine metabolites in HEK293 cells incubated with 6MP (3 μM) or the combination 6MP (3 μM)
Jan Söderman (380629), Sofie Haglund (380627), Sven Almer (8167), Svante Vikingsson (3826924)   +3 more
core   +1 more source

Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure.

, 2004
Oxypurinol, the active metabolite of allopurinol and a potent xanthine oxidase inhibitor (XOI), is under evaluation as a novel agent for the treatment of congestive heart failure (HF).
Brown, Joanne, BSc, Mann, Douglas L, MD, Givertz, Michael M, MD, Hare, Joshua M, MD, Freudenberger, Ronald S, MD, Moore, Alan, Colucci, Wilson S, MD, Schwarz, Richard P, PhD   +7 more
core   +2 more sources

Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01

, 2014
Allopurinol (ALP) hypersensitivity is a major cause of severe cutaneous adverse reactions and is strongly associated with the HLA-B*58:01 allele. However, it can occur in the absence of this allele with identical clinical manifestations.
Yun, James Jin Sup, Yerly, Daniel, Marcaida, Maria J, Pichler, Werner Joseph, Eriksson, Klara K, Jamin, Heidi, Fontana, Stefano   +6 more
core   +1 more source

Einfluss von Oxypurinol auf die koronare und periphere Endothelfunktion von Patienten mit koronarer Herzerkrankung

, 2008
Es wird der Einfluss einer intravenösen Gabe von Oxypurinol, einem Inhibitor der Xanthinoxidase, auf die Endothelfunktion bei Patienten mit koronarer Herzerkrankung als einer Manifestation der Atherosklerose untersucht. Als Indikator der Endothelfunktion
Koss, Klaus Gustav
core  

Free radical scavenging and antioxidant activity of allopurinol and oxypurinol in experimental lens-induced uveitis [PDF]

, 1994
Purpose. In addition to the inhibition of xanthine oxidase, allopurinol is known to act, dependent on the dose, as a free radical scavenger, an antioxidant, and a "scavenger" of hypochlorous acid. This activity was investigated using a model of
T Boker, A J Augustin, J Lutz, S H, -H Blumenroder, M Spitznas''   +5 more
core  

Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy

, 2006
Increased reactive oxygen species (ROS) generation is implicated in cardiac remodeling in heart failure (HF). As xanthine oxidoreductase (XOR) is 1 of the major sources of ROS, we tested whether XOR inhibition could improve cardiac performance and induce
Saraiva, Roberto Magalhães [UNIFESP], Berry, C. E., MINHAS, Khalid M, Schuleri, K. H., Lehrke, S., SALIARIS, Anastasios P, DECHUN LI, DECHUN, MEIZI ZHENG, MEIZI, Vandegaer, K. M., Saliaris, A. P., BERRY, Cristine E, Hare, J. M., LEHRKE, Stephanie, VANDEGAER, Konrad M, Zheng, M. Z., SARAIVA, Roberto M, Minhas, K. M., SCHULERI, Karl H, Li, D. C., HARE, Joshua M   +19 more
core   +1 more source

An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia

Vascular Health and Risk Management, 2017
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Abstract: Several studies suggest that chronic hyperuricemia, the main ...
Bove M, Cicero AFG, Veronesi M, Borghi C
doaj  

Effects of allopurinol and of oxypurinol on turkey liver xanthine dehydrogenase [PDF]

FEBS Letters, 1978
Ní Fhaoláin, Íde, Coughlan, Michael P.   +1 more
openaire   +2 more sources

Effect of allopurinol and oxypurinol treatment on apoptosis in an experimental testicular torsion model. [PDF]

Ulus Travma Acil Cerrahi Derg
Bilaloglu E, Duman L, Erzurumlu Y, Ertunc O, Kart Y.   +4 more
europepmc   +1 more source