Results 111 to 120 of about 524 (148)

Plasma oxypurinol as a measure of adherence in clinical trials

Annals of the Rheumatic Diseases, 2018
Adherence to urate-lowering therapy (ULT) in people with gout is often poor. A recent systematic review revealed 10%–46% of people with gout adhere to treatment.1 Among chronic diseases, gout has particularly low adherence rates.2 Adherence in clinical trials of ULT is a particularly important issue, as the primary efficacy endpoint for most studies ...
Lisa K, Stamp, Tony, Merriman, Christopher, Frampton, Mei, Zhang, Mary, Wallace, Jeffrey N, Miner, Nicola, Dalbeth   +6 more
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On the Specificity of Allopurinol and Oxypurinol as Inhibitors of Xanthine Oxidase. A Pulse Radiolysis Determination of Rate Constants for Reaction of Allopurinol and Oxypurinol with Hydroxyl Radicals

Free Radical Research Communications, 1988
Allopurinol has been employed as a "specific" inhibitor of xanthine oxidase in studies of hypoxic/reoxygenation injury. Pulse radiolysis was used to establish rate constants for the reactions of allopurinol and its major metabolite oxypurinol with hydroxyl radicals: values were (1.45 +/- 0.24) x 10(9) M-1 s-1 for allopurinol and (4.95 +/- 0.84) x 10(9)
Barry Halliwell, B M Hoey
exaly   +3 more sources

The Effect of Dietary Protein on the Clearance of Allopurinol and Oxypurinol

New England Journal of Medicine, 1985
A decrease in dietary protein is known to depress renal plasma flow and creatinine clearance. Using a randomized crossover design, we investigated the pharmacokinetics of allopurinol and its principal metabolite, oxypurinol, after oral administration of 600 mg of allopurinol in six normal subjects receiving a high-protein (268 g per day) or low-protein
W G, Berlinger, G D, Park, R, Spector
openaire   +2 more sources

Allergic Reaction to Allopurinol with Cross-Reactivity to Oxypurinol

Annals of Internal Medicine, 1976
A 25-year-old white man with gout and nephropathy and with a previous reaction to allopurinol was given a trial dose of oxypurinol. He developed malaise, a generalized erythematous reaction with edema, pruritus, and emesis; this was clinically identical to the reaction he experienced with allopurinol.
O, Lockard, C, Harmon, K, Nolph, W, Irvin   +3 more
openaire   +2 more sources

Effect of furosemide on renal excretion of oxypurinol and purine bases

Metabolism, 2001
To examine whether furosemide affects the plasma concentration and urinary excretion of purine bases and oxypurinol, we administered allopurinol (300 mg) orally to 6 healthy subjects and then administered furosemide (20 mg) intravenously 10 hours later. Furosemide (20 mg) decreased the urinary excretion of uric acid by 40% (P < .01), oxypurinol by 39% (
T, Yamamoto, Y, Moriwaki, S, Takahashi, Z, Tsutsumi, T, Hada   +4 more
openaire   +2 more sources

Urinary-Tract Stones Resulting from the Excretion of Oxypurinol

New England Journal of Medicine, 1975
COMPOUNDS that inhibit the enzyme, xanthine oxidase, are useful in the treatment of disorders of purine metabolism.
A R, Landgrebe, W L, Nyhan, M, Coleman
openaire   +2 more sources

Oxypurinol reduces focal ischemic brain injury in the rat

Neuroscience Letters, 1991
When measured within 2 days of a unilateral occlusion of the middle cerebral artery (MCA) combined with tandem occlusion of the ipsilateral common carotid artery in rats, contralateral neurological deficits were detectable, with brain swelling and a consistent degree of neocortical infarction in the ipsilateral hemisphere.
Y, Lin, J W, Phillis
openaire   +2 more sources

Engineering oxypurinol-responsive riboswitches based on bacterial xanthine aptamers for gene expression control in mammalian cell culture

Nucleic Acids Research
Riboswitch-mediated control of gene expression without the interference of potentially immunogenic proteins is a promising approach for the development of tailor-made tools for biological research and the advancement of gene therapies.
Jörg S Hartig, Matthias Klugmann
exaly   +2 more sources

Effect of norepinephrine on the urinary excretion of purine bases and oxypurinol

Metabolism, 2001
To examine whether norepinephrine affects the plasma concentrations and urinary excretion of purine bases and oxypurinol, we orally administered allopurinol (300 mg) to 5 healthy subjects and 9 hours later intravenously administered norepinephrine (12 to 20 microg/kg body weight), which causes a more than 10 mm Hg increase in diastolic pressure for 2 ...
T, Yamamoto, Y, Moriwaki, S, Takahashi, Z, Tsutsumi, T, Hada   +4 more
openaire   +2 more sources

Oxypurinol Nephrolithiasis in Regional Enteritis Secondary to Allopurinol Therapy

Annals of Internal Medicine, 1980
A patient with regional enteritis and recurrent uric acid nephrolithiasis was treated with allopurinol. While on 600 mg of allopurinol daily, she began to pass many small, soft, yellow stones. Analysis of the stones by liquid chromatographic and gas chromatograph/mass spectrometric techniques revealed that their major constituent was oxypurinol, a ...
R M, Stote, L H, Smith, J W, Dubb, T P, Moyer, F, Alexander, J L, Roth   +5 more
openaire   +2 more sources