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The pharmacokinetics of oral and intravenous allopurinol and intravenous oxypurinol in the horse
Journal of Veterinary Pharmacology and Therapeutics, 1995The pharmacokinetics of oral and intravenous allopurinol was studied in five horses and compared with intravenous oxypurinol. The plasma concentration vs. time curves, following intravenous administration of 5 mg/kg, were best described by the biexponential equations Cp = 106.58e‐25.141+ 159.93e‐10.96tfor allopurinol and Cp = 321.09e‐972t+ 82.39e‐0 ...
P C, Mills, M, Dunnett, N C, Smith
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Effect of Amino Acids on the Excretions of Purine Bases and Oxypurinol
Nephron, 2008To investigate whether or not amino acids affect the urinary excretion of purine bases and oxypurinol, a 12% amino acid solution was infused to 6 subjects who took allopurinol (300 mg) 6 h before the study. Amino acid infusion increased the urinary excretion and the fractional clearance of uric acid and oxypurinol and decreased the plasma concentration
T, Yamamoto +4 more
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Allopurinol hypersensitivity syndrome: hypersensitivity to oxypurinol but not allopurinol
Clinical and Experimental Dermatology, 1998Allopurinol is a xanthine oxidase inhibitor widely used to control plasma uric acid levels. Episodes of hypersensitivity to the drug are not rare. A severe form of this with a generalized exanthem, fever and liver involvement has been termed the allopurinol hypersensitivity syndrome (AHS).
null HAMANAKA +4 more
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The effect of benzbromarone on allopurinol/oxypurinol kinetics in patients with gout
European Journal of Clinical Pharmacology, 1993The objectives of this study were to establish if, and to what extent, benzbromarone affects allopurinol/oxypurinol kinetics, and to compare the uric acid lowering capabilities of Allomaron (allopurinol 100 mg plus benzbromarone 20 mg) with the effects of allopurinol alone in patients with confirmed gout.
F O, Müller +5 more
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Oxypurinol Reduces Ischemic Brain Injury in the Gerbil and Rat
1991The pathophysiology of brain ischemia is characterized by a complex sequence of events, which include biochemical, hemodynamic and electrophysiological processes. Decreases in cerebral blood flow (CBF) below a critical threshold result in energy failure, tissue acidosis, disturbed ion homeostasis, with cellular Na+ and Ca++ influx and K+ efflux ...
J W, Phillis, Y, Lin
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Oxypurinol – A novel marker for wastewater contamination of the aquatic environment
Water Research, 2015The anti-gout agent allopurinol is one of the most prescribed pharmaceuticals in Germany and is widely metabolized into oxypurinol (80%) as well as the corresponding riboside conjugates (10%) within the human body. To investigate the occurrence of allopurinol and oxypurinol in the urban water cycle an analytical method was developed based on solid ...
Jan Funke +3 more
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Effect of Lactate Infusion on Renal Transport of Purine Bases and Oxypurinol
Nephron, 2008To investigate whether or not lactic acid inhibits the renal transport of oxypurines and oxypurinol, we administered physiological saline containing 0.2 mol sodium lactate to 5 normal subjects intravenously. Lactate infusion decreased the fractional clearance of uric acid, but the fractional clearances of hypoxanthine, xanthine and oxypurinol were not ...
T, Yamamoto +4 more
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Effect of Glucose Infusion on the Renal Transport of Purine Bases and Oxypurinol
Nephron, 2008The effect of glucose infusion on renal handling of purine bases and oxypurinol was examined in 6 normal subjects. Five hundred milliliters of 1.1 M glucose solution were administered intravenously in 1 h. Fractional clearances of uric acid, xanthine and oxypurinol were significantly increased during glucose infusion, but that of hypoxanthine was not ...
Y, Moriwaki +4 more
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Effect of Losartan and Furosemide on the Urinary Excretion of Oxypurinol and Uric Acid
2006Losartan potassium (losartan) is an angiotensin II receptor antagonist used for the treatment of hypertension1, which opposes the action of angiotensin II at the AT1 receptor. Losartan has a uricosuric action, which depends on the inhibition of uric acid reabsorption in the proximal tubules2.
T, Yamamoto +4 more
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Analysis of allopurinol and oxypurinol in plasma and its application to metabolic studies
Biopharmaceutics and Drug Disposition, 1980S, Sved, D L, Wilson
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