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1989
In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3.
T, Yamamoto +4 more
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In normal persons and gouty subjects, allopurinol is mainly converted to oxypurinol by xanthine oxidase and oxypurinol is then excreted unchanged by the kidney1. The concentration of serum oxypurinol is directly related to the renal clearance of oxypurinol2, which is increased or decreased under various conditions2, 3.
T, Yamamoto +4 more
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Quantitative Liquid Chromatography of Allopurinol and Oxypurinol in Human Plasma and Urine
Therapeutic Drug Monitoring, 1985A high performance liquid chromatographic (HPLC) assay is described for allopurinol and oxypurinol determination in human plasma and urine, in the range expected during therapy. The procedure involves addition of trichloroacetic acid to samples, followed by centrifugation.
J M, Failler, R, Farinotti, A, Dauphin
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Renal clearances of oxypurinol and inulin on an isocaloric, low-protein diet
Clinical Pharmacology and Therapeutics, 1988In previous studies a low-calorie, low-protein diet caused a sustained reduction in both oxypurinol and uric acid renal clearances (CLR). With the hypothesis that the decrease in CLR was due to the low-protein and not the low-caloric content of the diet, we studied the CLR of oxypurinol, uric acid, creatinine, and inulin in normal subjects during ...
T M, Kitt +4 more
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Beneficial effects of oxypurinol pretreatment in stunned, reperfused canine myocardium
Cardiovascular Research, 1989The mechanism of reperfusion induced injury in acutely ischaemic myocardium is controversial but may be connected with oxygen free radical generation. However, chronic allopurinol treatment has beneficial effects in ischaemic myocardium which are not due to its inhibition of xanthine oxidase induced oxygen free radical production.
H H, Holzgrefe, J K, Gibson
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The Allopurinol Hypersensitivity Syndrome: Its Relation to Plasma Oxypurinol Levels
1989Allopurinol (4-hydroxypyrazolo (3, 4-d)pyrimidine) is a potent inhibitor of uric acid synthesis commonly prescribed for the treatment of gout and other hyperuricemic states (1, 2). Most of the allopurinol is rapidly oxidized to oxypurinol, its major metabolic product (3), which in turn is a potent inhibitor of the enzyme xanthine oxydase.
E, Casas +5 more
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Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity.
The Journal of rheumatology, 1989Monitoring of plasma oxypurinol has been proposed to prevent allopurinol side effects. An 89-year-old man developed a severe desquamative rash, fever, eosinophilia, hepatocellular injury and renal failure after allopurinol administration. Eight hours after the last dose, plasma allopurinol was undetectable and plasma oxypurinol was 50 mumol/l.
J G, Puig +4 more
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