Results 81 to 90 of about 1,837 (187)

Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials

BMC Cardiovascular Disorders, 2018
Background Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from ...
Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d’Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein, Guilherme Gomes Dias Campos   +8 more
doaj   +1 more source

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Journal of Translational Medicine
Background Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, and coxsackievirus B3.
JinFang Hao, Xiaoyan Zhang, Ruixian Hu, Xiufeng Lu, Hui Wang, Yuanhong Li, Kai Cheng, Qingshan Li   +7 more
doaj   +1 more source

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Febuxostat suppresses LPS-induced ROS formation and MCP-1 production more effectively than allopurinol and oxypurinol.

, 2013
(A) ROS was produced by buttermilk XO (10 mU/mL) and xanthine (100 µM) in the absence or presence of febuxostat (Feb, 100 nM), allopurinol (Allo, 100 µM) or oxypurinol (Oxy, 100 µM), and detected by DCF ROS indicator. Fluorescence was measured.
Syunsuke Tsujimoto (462920), Nathalie Busso (8780), Alexander So (8781), Annette Ives (218882), Mizuho Tamura (462921), Yoshihiro Yamanaka (462922), Johji Nomura (462919)   +6 more
core   +1 more source

Chemo- and Regioselective Functionalization of Uracil Derivatives. Applications to the Synthesis of Oxypurinol and Emivirine

, 2016
A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo- and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such
Paul Knochel (1376235), Nadège Boudet (2441230)   +1 more
core   +1 more source

Clinical and pathogenetic importance of hormonal natriuretic peptides in gout

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. In addition to purine metabolism disorders, systems of pro-inflammatory cytokines, matrix metalloproteinases and eicosanoids, various medium molecular weight compounds can participate in the pathogenesis of gout, including natriuretic ...
O.V. Syniachenko, D.M. Fedorov, M.V. Yermolaieva, V.V. Pylypenko   +3 more
doaj   +1 more source

Comparative assessment of primary and paraneoplastic gout in lung cancer

Zaporožskij Medicinskij Žurnal, 2018
Introduction. Lung cancer (LС) is the most common cause of the so-called paraneoplastic syndrome (PNPS) development, caused by the complex immunoinflammatory, degenerative and vascular distant changes.
O. V. Syniachenko, Yu. V. Dumanskyi, Ye. D. Yehudina, O. Ye. Chernyshova, P. A. Stepko, D. M. Fedorov   +5 more
doaj   +1 more source

Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B [PDF]

, 2009
BACKGROUND: Fetal hypoxia is an important determinant of neonatal encephalopathy caused by birth asphyxia, in which hypoxia-induced free radical formation plays an important role.
Venegas, Maria Elena, DERKS, J. B., Buonocore, Giuseppe, Rademaker, Carin M. A., TORRANCE, H. L., LONGINI, M., Visser, Gerard H. A., Longini, Mariangela, Van Bel, Frank, Van Den Berg, Paul, Baquero, Hernando, VENEGAS, M., Torrance, Helen L., Benders, Manon J., BOS, A. F., VAN DEN BERG, P., BUONOCORE, G., Bos, Arie F., BENDERS, M. J., VISSER, G. H., Derks, Jan B., BAQUERO, H., RADEMAKER, C. M., Venegas, MariaElena, VAN BEL, F.   +24 more
core   +1 more source

Comparison of Aroma and Taste Profiles of Kiwi Wine Fermented with/without Peel by Combining Intelligent Sensory, Gas Chromatography-Mass Spectrometry, and Proton Nuclear Magnetic Resonance

Foods
Kiwi wine (KW) is tipically made by fermenting juice from peeled kiwifruit, resulting in the disposal of peel and pomace as by-products. However, the peel contains various beneficial compounds, like phenols and flavonoids.
Bingde Zhou, Xiaochen Liu, Qiuyu Lan, Fang Wan, Zhibo Yang, Xin Nie, Zijian Cai, Bin Hu, Junni Tang, Chenglin Zhu, Luca Laghi   +10 more
doaj   +1 more source

Influence of xanthine oxidase inhibitors allopurinol and oxypurinol on the course of body weight, on body composition and spontaneous activity in a rat model of tumour cachexia

, 2010
Die zur Entstehung einer Kachexie bei Tumorerkrankung führenden Signalwege sind noch nicht vollständig verstanden. In diesem Zusammenhang wurde eine erhöhte Aktivität des Enzyms Xanthinoxidase berichtet, welche über eine Steigerung der Produktion ...
Hartmann, Kai
core   +1 more source