Results 81 to 90 of about 524 (148)

Xanthine oxidase inhibitors for prevention of cardiovascular events: a systematic review and meta-analysis of randomized controlled trials

BMC Cardiovascular Disorders, 2018
Background Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from ...
Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d’Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein, Guilherme Gomes Dias Campos   +8 more
doaj   +1 more source

Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens

Journal of Animal Science and Biotechnology
Background Research on low-protein-level diets has indicated that even though the profiles of essential amino acids (EAAs) follow the recommendation for a normal-protein-level diet, broilers fed low-protein diets failed to achieve productive performance ...
Bin Wang, Xiaodan Zhang, Yongfa Liu, Mingkun Gao, Mi Wang, Yuan Wang, Xinzhi Wang, Yuming Guo   +7 more
doaj   +1 more source

Mass Spectrometric Analysis of Purine Intermediary Metabolism Indicates Cyanide Induces Purine Catabolism in Rabbits

Metabolites
Purines are the building blocks of DNA/RNA, energy substrates, and cofactors. Purine metabolites, including ATP, GTP, NADH, and coenzyme A, are essential molecules in diverse biological processes such as energy metabolism, signal transduction, and enzyme
Jordan Morningstar, Jangwoen Lee, Sari Mahon, Matthew Brenner, Anjali K. Nath   +4 more
doaj   +1 more source

Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01 [PDF]

, 2014
Allopurinol (ALP) hypersensitivity is a major cause of severe cutaneous adverse reactions and is strongly associated with the HLA-B*58:01 allele. However, it can occur in the absence of this allele with identical clinical manifestations.
Yun, James Jin Sup, Yerly, Daniel, Marcaida, Maria J, Pichler, Werner Joseph, Eriksson, Klara K, Jamin, Heidi, Fontana, Stefano   +6 more
core   +1 more source

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease [PDF]

Background: The CRUCIAL trial (NCT04217421) is investigating the effect of postnatal and perioperative administration of allopurinol on postoperative brain injury in neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with ...
Koomen, Erik, Stegeman, Raymond,, Nijman, Joppe,, Breur, Johannes M. P. J., Benders, Manon J. N. L., Jansen, Nicolaas J.G., Huitema, Alwin D. R.,, Allegaert, Karel,, Nijman, Maaike, Dorlo, Thomas P.C., Chu, Wan-Yu, Benders, Manon J. N. L.,, Allegaert, Karel; id_orcid, Jansen, Nicolaas J. G., van Loon, Kim,, Dorlo, Thomas P. C.,, Nijman, Joppe, van Loon, Kim, Breur, Johannes M. P. J.,, Chu, Wan-Yu,, Chu, Wan Yu, Huitema, Alwin D. R., Jansen, Nicolaas J. G.,, Allegaert, Karel, Nijman, Maaike,, Koomen, Erik,, Dorlo, Thomas P. C., Breur, Johannes M.P.J., Stegeman, Raymond, Huitema, Alwin D.R., Benders, Manon J.N.L.   +30 more
core   +3 more sources

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Journal of Translational Medicine
Background Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, and coxsackievirus B3.
JinFang Hao, Xiaoyan Zhang, Ruixian Hu, Xiufeng Lu, Hui Wang, Yuanhong Li, Kai Cheng, Qingshan Li   +7 more
doaj   +1 more source

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Clinical and pathogenetic importance of hormonal natriuretic peptides in gout

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. In addition to purine metabolism disorders, systems of pro-inflammatory cytokines, matrix metalloproteinases and eicosanoids, various medium molecular weight compounds can participate in the pathogenesis of gout, including natriuretic ...
O.V. Syniachenko, D.M. Fedorov, M.V. Yermolaieva, V.V. Pylypenko   +3 more
doaj   +1 more source

Comparative assessment of primary and paraneoplastic gout in lung cancer

Zaporožskij Medicinskij Žurnal, 2018
Introduction. Lung cancer (LС) is the most common cause of the so-called paraneoplastic syndrome (PNPS) development, caused by the complex immunoinflammatory, degenerative and vascular distant changes.
O. V. Syniachenko, Yu. V. Dumanskyi, Ye. D. Yehudina, O. Ye. Chernyshova, P. A. Stepko, D. M. Fedorov   +5 more
doaj   +1 more source

Comparison of Aroma and Taste Profiles of Kiwi Wine Fermented with/without Peel by Combining Intelligent Sensory, Gas Chromatography-Mass Spectrometry, and Proton Nuclear Magnetic Resonance

Foods
Kiwi wine (KW) is tipically made by fermenting juice from peeled kiwifruit, resulting in the disposal of peel and pomace as by-products. However, the peel contains various beneficial compounds, like phenols and flavonoids.
Bingde Zhou, Xiaochen Liu, Qiuyu Lan, Fang Wan, Zhibo Yang, Xin Nie, Zijian Cai, Bin Hu, Junni Tang, Chenglin Zhu, Luca Laghi   +10 more
doaj   +1 more source