Results 21 to 30 of about 1,837 (187)

Females present higher dose‐adjusted drug concentrations of metoprolol and allopurinol/oxypurinol than males

Clinical and Translational Science, 2023
Females present a higher risk of adverse drug reactions. Sex‐related differences in drug concentrations may contribute to these observations but they remain understudied given the underrepresentation of females in clinical trials.
Jessica Hindi, Marc‐Olivier Pilon, Maxime Meloche, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus   +13 more
doaj   +1 more source

Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Allopurinol is used to treat hyperuricemia and gout. It is metabolized to oxypurinol by xanthine oxidase (XO), and aldehyde oxidase (AO). Allopurinol and oxypurinol are potent XO inhibitors that reduce the plasma uric acid levels.
Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura, Shigeru Ohta   +5 more
doaj   +1 more source

Evaluation of the Usefulness of Topological Indices for Predicting Selected Physicochemical Properties of Bioactive Substances with Anti-Androgenic and Hypouricemic Activity

Molecules, 2023
Due to the observed increase in the importance of computational methods in determining selected physicochemical parameters of biologically active compounds that are key to understanding their ADME/T profile, such as lipophilicity, there is a great need ...
Dawid Wardecki, Małgorzata Dołowy, Katarzyna Bober-Majnusz   +2 more
doaj   +1 more source

Pharmacodynamics of oxypurinol after administration of allopurinol to healthy subjects [PDF]

British Journal of Clinical Pharmacology, 1996
1 Eight healthy subjects received 50, 100, 300, 600 and 900 mg allopurinol daily for 1 week each, in random order with 1 week separating each treatment period. The pre‐dose plasma concentration of oxypurinol, the extent of inhibition of xanthine oxidase, plasma urate concentration and urine urate excretion rate were assessed on the last 2 days of each
S, Graham, R O, Day, H, Wong, A J, McLachlan, L, Bergendal, J O, Miners, D J, Birkett   +6 more
openaire   +2 more sources

Enhanced and Sustained Transdermal Delivery of Oxypurinol Using Thermosensitive Gel Combined with Polymeric Solid Microneedles [PDF]

ACS Omega
Siti Nur Fatimah S. Mohamad, Stephanie Stephanie, Zulfiayu Sapiun, Frederika Tangdilintin, Sulistiawati Sulistiawati, Achmad Himawan, Yusnita Rifai, Habibie Habibie, Aliyah Aliyah, Muhammad Aswad, Andi Dian Permana   +10 more
doaj   +2 more sources

Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia

Frontiers in Neurology, 2019
Background: Asphyxia is the most common cause of brain damage in newborns. Substantial evidence indicates that leukocyte recruitment in the cerebral vasculature during asphyxia contributes to this damage. We tested the hypothesis that superoxide radical (
Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Laura L. Dugan, Jeffrey M. Gidday   +9 more
doaj   +1 more source

Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells - Effects on gene expression levels and thiopurine metabolism. [PDF]

PLoS ONE, 2017
Combination treatment with low-dose thiopurine and allopurinol (AP) has successfully been used in patients with inflammatory bowel disease with a so called skewed thiopurine metabolite profile.
Sofie Haglund, Svante Vikingsson, Sven Almer, Jan Söderman   +3 more
doaj   +1 more source

Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease. [PDF]

Clin Pharmacokinet
BACKGROUND: The CRUCIAL trial (NCT04217421) is investigating the effect of postnatal and perioperative administration of allopurinol on postoperative brain injury in neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with ...
Chu WY, Nijman M, Stegeman R, Breur JMPJ, Jansen NJG, Nijman J, van Loon K, Koomen E, Allegaert K, Benders MJNL, Dorlo TPC, Huitema ADR, CRUCIAL trial consortium.   +12 more
europepmc   +4 more sources

Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension

Redox Biology, 2016
Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO ...
Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Danielle A. Guimaraes, Sandra O. Conde Tella, Ana L. Furlan Blanco, Celio D. Angelis, Alan N. Schechter, Jose E. Tanus-Santos   +7 more
doaj   +1 more source

Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis

BMC Cancer, 2023
Background Pancreatic cancer is a highly lethal disease with no effective treatments. Lactobacillus casei (L. casei) and Lactobacillus reuteri (L. reuteri) exhibited therapeutic effects on several cancers, but their roles in pancreatic cancer are unknown.
Zemin Zhu, Bo Yi, Zikai Tang, Xun Chen, Ming Li, Tao Xu, Zhijian Zhao, Caixi Tang   +7 more
doaj   +1 more source