Results 21 to 30 of about 24,044 (225)

Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids

Journal of Lipid Research, 2001
Lysophosphatidylcholine is an abundant component of plasma and oxidized LDL that displays several biological activities, some of which may occur through the platelet-activating factor (PAF) receptor.
Gopal K. Marathe, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre   +6 more
doaj   +1 more source

Lyso-Gb3 activates Notch1 in human podocytes [PDF]

Human Molecular Genetics, 2015
Podocyte injury is an early feature of Fabry nephropathy, but the molecular mechanisms of podocyte injury are poorly understood. Lyso-Gb3 accumulates in serum in Fabry disease and increases extracellular matrix synthesis in podocytes. We explored the contribution of Notch1 signaling, a mediator of podocyte injury, to lyso-Gb3-elicited responses in ...
Maria D, Sanchez-Niño, Daniel, Carpio, Ana Belen, Sanz, Marta, Ruiz-Ortega, Sergio, Mezzano, Alberto, Ortiz   +5 more
openaire   +2 more sources

An observational study to investigate the relationship between plasma glucosylsphingosine (lyso-Gb1) concentration and treatment outcomes of patients with Gaucher disease in Japan

Orphanet Journal of Rare Diseases, 2022
Background Gaucher disease (GD) is an autosomal recessive disease caused by GBA1 mutations resulting in glucosylceramide accumulation in macrophages.
Hiroyuki Ida, Yuko Watanabe, Rieko Sagara, Yoichi Inoue, Jovelle Fernandez   +4 more
doaj   +1 more source

Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions. [PDF]

PLoS ONE, 2013
The present study aimed to show the in vivo mechanisms of action of an indole-thiazolidine molecule peroxisome-proliferator activated receptor pan-agonist (PPAR pan) and cyclooxygenase (COX) inhibitor, LYSO-7, in an ethanol/HCl-induced (Et/HCl) gastric ...
José Roberto Santin, Isabel Daufenback Machado, Stephen F P Rodrigues, Simone Teixeira, Marcelo N Muscará, Suely Lins Galdino, Ivan da Rocha Pitta, Sandra H P Farsky   +7 more
doaj   +1 more source

Chronic Effect of a Cafeteria Diet and Intensity of Resistance Training on the Circulating Lysophospholipidome in Young Rats

Metabolites, 2021
The daily practice of physical exercise and a balanced diet are recommended to prevent metabolic syndrome (MetS). As MetS is a multifactorial disorder associated with the development of serious diseases, the advancement of comprehensive biomarkers could ...
Susana Suárez-García, Antoni Caimari, Josep M. del Bas, Jaume Lalanza, Rosa M. Escorihuela, Manuel Suárez, Cristina Torres-Fuentes, Lluís Arola   +7 more
doaj   +1 more source

Lyso-IP: Uncovering Pathogenic Mechanisms of Lysosomal Dysfunction

Biomolecules, 2022
Lysosomes are ubiquitous membrane-bound organelles found in all eukaryotic cells. Outside of their well-known degradative function, lysosomes are integral in maintaining cellular homeostasis. Growing evidence has shown that lysosomal dysfunction plays an important role not only in the rare group of lysosomal storage diseases but also in a host of ...
Chase Chen, Ellen Sidransky, Yu Chen
openaire   +3 more sources

Epithelial-Mesenchymal Transition in Kidney Tubular Epithelial Cells Induced by Globotriaosylsphingosine and Globotriaosylceramide. [PDF]

PLoS ONE, 2015
Fabry disease is a lysosomal storage disorder caused by deficiency of alpha-galactosidase A (α-gal A), which results in the deposition of globotriaosylceramide (Gb3) in the vascular endothelium.
Yeo Jin Jeon, Namhee Jung, Joo-Won Park, Hae-Young Park, Sung-Chul Jung   +4 more
doaj   +1 more source

Insights into the Value of Lyso-Gb1 as a Predictive Biomarker in Treatment-Naïve Patients with Gaucher Disease Type 1 in the LYSO-PROOF Study

Diagnostics, 2023
Gaucher disease (GD) is a rare autosomal recessive disorder arising from bi-allelic variants in the GBA1 gene, encoding glucocerebrosidase. Deficiency of this enzyme leads to progressive accumulation of the sphingolipid glucosylsphingosine (lyso-Gb1 ...
Filipa Curado, Sabine Rösner, Susanne Zielke, Gina Westphal, Ulrike Grittner, Volha Skrahina, Mohammed Alasel, Ahmad Mehmood Malik, Christian Beetz, Tobias Böttcher, Gal Barel, Ashish Prasad Sah, Tama Dinur, Nadeem Anjum, Quidad Ichraf, Yamna Kriouile, Zahra Hadipour, Fatemeh Hadipour, Shoshana Revel-Vilk, Claudia Cozma, Jörg Hartkamp, Huma Cheema, Ari Zimran, Peter Bauer, Arndt Rolfs   +24 more
doaj   +1 more source

Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus. [PDF]

PLoS Pathogens, 2018
Positive-sense RNA virus intracellular replication is intimately associated with membrane platforms that are derived from host organelles and comprised of distinct lipid composition.
Susann Liebscher, Rebecca L Ambrose, Turgut E Aktepe, Andrea Mikulasova, Julia E Prier, Leah K Gillespie, Adam J Lopez-Denman, Thusitha W T Rupasinghe, Dedreia Tull, Malcolm J McConville, Jason M Mackenzie   +10 more
doaj   +1 more source

Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells

Journal of Lipid Research, 1999
Lysophosphatidylcholine (lyso-PC) and arachidonate are products of phosphatidylcholine hydrolysis by phospholipase A2. In this study, the modulation of arachidonate release by exogenous lyso-PC in rat heart myoblastic H9c2 cells was examined.
Leonard S. Golfman, Norman J. Haughey, Jason T. Wong, Jenny Y. Jiang, Douglas Lee, Jonathan D. Geiger, Patrick C. Choy   +6 more
doaj   +1 more source