Results 71 to 80 of about 24,044 (225)

Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry.

Journal of Lipid Research, 1986
Two physicochemical methods have been developed for the quantitative analysis of lyso-platelet activating factor (lyso-PAF) based on gas-liquid chromatography-mass spectrometry (GLC/MS) and fast atom bombardment-mass spectrometry (FAB/MS) using stable ...
P E Haroldsen, K L Clay, R C Murphy
doaj   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

A LYSO calorimeter for the SuperB factory

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2013
The SuperB project is an asymmetric e^+e^− accelerator of 10^(36) cm^(−2) s^(−1) design luminosity, capable of collecting a data sample of 50–75 ab^(−1) in five years running. The SuperB electromagnetic calorimeter (EMC) provides energy and direction measurement of photons and electrons, and is used for identification of electrons versus other charged ...
G. Eigen, Z. Zhou, D. Chao, C. H. Cheng, B. Echenard, K. T. Flood, D. G. Hitlin, F. C. Porter, R. Y. Zhu, G. D. Nardo, G. De Nardo, C. Sciacca, M. Bizzarri, C. Cecchi, S. Germani, P. Lubrano, E. Manoni, A. Papi, G. Scolieri, A. Rossi, V. Bocci, G. Chiodi, FACCINI, Riccardo, FIORE, SALVATORE, E. Furfaro, GAUZZI, Paolo, G. Martellotti, F. Pellegrino, V. Pettinacci, D. Pinci, L. Recchia, A. Zullo, P. Branchini, A. Budano   +33 more
openaire   +5 more sources

Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems

VIEW, EarlyView.
A bionic nanomedicine system with core–shell structure (Nm‐pAu/CP/KU) was constructed. PEGylated gold nanoparticles (pAu) were loaded with cisplatin (CP) and a radiochemotherapy sensitizer (KU‐60019) to form the core pAu/CP/KU, and homologous nasopharyngeal carcinoma cell membrane vesicles (Nm) were used as the shell.
Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui   +4 more
wiley   +1 more source

Development of Organelle Replacement Therapy Using a Stearyl-Polyhistidine Peptide against Lysosomal Storage Disease Cells

Molecules, 2019
We previously reported on a polyhistidine peptide, His16 peptide, as a new cell-penetrating peptide. This peptide is anticipated to be a new carrier for drug delivery systems (DDSs) for targeting intracellular lysosomes because it can transport ...
Taiki Hayashi, Riku Okamoto, Tsuyoshi Kawano, Takashi Iwasaki   +3 more
doaj   +1 more source

LSO/LYSO Crystals for Future HEP Experiments

Journal of Physics: Conference Series, 2011
Because of their high stopping power (X_0 = 1.14 cm), fast (t = 40 ns) and bright (4 times of BGO) scintillation and good radiation hardness, cerium doped silicate based heavy crystal scintillators (LSO and LYSO) have attracted a broad interest in the high energy physics community pursuing precision electromagnetic calorimeter in severe radiation ...
Mao, Rihua, Zhang, Liyuan, Zhu, Ren-Yuan
openaire   +2 more sources

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

Quality of Long LSO/LYSO Crystals

Journal of Physics: Conference Series, 2012
Because of their high stopping power (X_0 = 1.14 cm) and fast (t = 40 ns) and bright (4 times of BGO) scintillation cerium doped silicate based heavy crystal scintillators (LSO and LYSO) have attracted a broad interest in the high energy physics community pursuing precision electromagnetic calorimeter for future high energy physics experiments ...
openaire   +2 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone.

Journal of Lipid Research, 1987
Two platelet-activating factor (PAF) analogs containing a methyl group at C2 of the glycerol moiety were synthesized, and some of their biochemical properties were investigated.
R Bittman, N M Witzke, T C Lee, M L Blank, F Snyder   +4 more
doaj   +1 more source