Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing [PDF]
mBioBacteriophages (phages) are bacterial-specific viruses that can be used alone or with antibiotics to reduce bacterial load. Most phages are unsuitable for therapy because they are “temperate” and can integrate into the host genome, forming a lysogen that
Rabia Fatima, Alexander P. Hynes
doaj +2 more sources
Noncanonical amino acids as prophage inducers for protein regulation in bacteria-based delivery systems [PDF]
mBioGenetically engineered bacteria represent a promising drug delivery tool for disease treatment. The development of new strategies for specific and independent protein regulation is necessary, especially for combination protein drug therapy.
Hongfang Liu +8 more
doaj +2 more sources
What makes a temperate phage an effective bacterial weapon? [PDF]
mSystemsTemperate bacteriophages (phages) are common features of bacterial genomes and can act as self-amplifying biological weapons, killing susceptible competitors and thus increasing the fitness of their bacterial hosts (lysogens).
M. J. N. Thomas +2 more
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H-NS Mutation-Mediated CRISPR-Cas Activation Inhibits Phage Release and Toxin Production of Escherichia coli Stx2 Phage Lysogen [PDF]
Frontiers in Microbiology, 2017 Qiang Fu, Zhaofei Wang, Jingjiao
exaly +2 more sources
Isolation and Characterization of the subcluster L2 Mycobacteriophage Underpass and its lysogen. [PDF]
MicroPubl BiolToth KR +17 more
europepmc +3 more sources
Temperate Bacteriophages—The Powerful Indirect Modulators of Eukaryotic Cells and Immune Functions
Viruses, 2021 Bacteriophages are natural biological entities that limit the growth and amplification of bacteria. They are important stimulators of evolutionary variability in bacteria, and currently are considered a weapon against antibiotic resistance of bacteria ...
Martyna Cieślik +5 more
doaj +1 more source
Mycobacteriophage Mcgavigan Uses Noncanonical Bxb1-Like Repressor for Heterotypic Superinfection Immunity. [PDF]
J Basic MicrobiolABSTRACT Mycobacteriophage Mcgavigan could be a promising candidate for use as a preventative agent against infections with Mycobacterium avium subsp. paratuberculosis. Bioinformatic analysis of the Mcgavigan genome revealed the presence of an operon containing a “Bxb1‐like” repressor.
Shafer N, Dubrule BE, De Buck J.
europepmc +2 more sources
A φSa3int (NM3) Prophage Domestication in <i>Staphylococcus aureus</i> Leads to Increased Virulence Through Human Immune Evasion. [PDF]
MedComm (2020)Prophages play a significant role in modulating bacterial virulence and pathogenicity. Our results suggest domestication of φSa3int prophage leads to reduced phagocytosis mediating escape of S. aureus from human innate immunity. As such, targeted identification of mobile genetic elements (MGEs) in addition to species and strain identification may lead ...
Nepal R +9 more
europepmc +2 more sources
An Efficient, Counter-Selection-Based Method for Prophage Curing in Pseudomonas aeruginosa Strains
Viruses, 2021 Prophages are bacteriophages in the lysogenic state, where the viral genome is inserted within the bacterial chromosome. They contribute to strain genetic variability and can influence bacterial phenotypes. Prophages are highly abundant among the strains
Esther Shmidov +5 more
doaj +1 more source
The rapid purification of T4 DNA ligase from a lambda T4 lig lysogen.
Journal of Biological Chemistry, 1980 Robert C. Tait +2 more
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