Results 101 to 110 of about 11,571 (196)

Epithelial Atg5 Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During Pseudomonas Infection

MedComm, Volume 6, Issue 7, July 2025.
This work illuminates the essential role of epithelial ATG5 in defending against P. aeruginosa. Atg5 deficiency impairs bacterial clearance and aggravates inflammation via AKT/PI3K/NF‐κB, inflammasome activation, and pyroptosis. Mechanistically, impaired mitophagy intensifies mitochondrial damage.
Junyi Wang, Lei Zhang, Yingying Liu, Yao Liu, Anying Xiong, Qin Ran, Xiang He, Vincent Kam Wai Wong, Colin Combs, Guoping Li, Min Wu   +10 more
wiley   +1 more source

The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]

, 2014
Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core   +2 more sources

Characterization of a Novel Thermobifida fusca Bacteriophage P318

Viruses, 2019
Thermobifida fusca is of biotechnological interest due to its ability to produce an array of plant cell wall hydrolytic enzymes. Nonetheless, only one T. fusca bacteriophage with genome information has been reported to date.
Jatuporn Cheepudom, Tzu-Ling Lin, Cheng-Cheng Lee, Menghsiao Meng   +3 more
doaj   +1 more source

Improving the solubility of single domain antibodies using VH‐like hallmark residues

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Single domain antibodies (sdAbs) can be generated from variable regions of heavy‐chain antibodies, which lack light chain and CH1 region. They have attracted attention due to their small size and molecular characteristics. Hydrophilic hallmark amino acids at framework region 2 (FR2) are key residues involved in the solubility of sdAbs ...
Yuta Uto, Makoto Nakakido, Takanori Yokoo, Jorge Fernandez‐Perez, Kevin Entzminger, Toshiaki Maruyama, C. J. Okumura, Daisuke Kuroda, Jose M. M. Caaveiro, Kouhei Tsumoto   +9 more
wiley   +1 more source

The influence of the accessory genome on bacterial pathogen evolution [PDF]

, 2011
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity.
Abu-Ali GS, Adiba S, Alfano JR, Arnold DL, Arnold DL, Arnold DL, Asadulghani M, Baharoglu Z, Baquero F, Barash I, Blondel CJ, Blondel CJ, Brüssow H, Cambray G, Chen J, Chen Y, Choi J, Colinon C, Croucher NJ, Dawes FE, De Gelder L, Diard M, Dillon SC, Douard G, Doyle M, Elsaied H, Fondi M, Freeman VJ, Gartemann KH, Gillings MR, Godfrey SAC, Govind R, Greenberg JT, Grillot-Courvalin C, Groisman EA, Guerin E, Hacker J, Hacker J, Halary S, Hassan F, Hazen TH, Hegstad K, Heinemann JA, Heringa S, Hochhut B, Holden MT, Huang L, Imamovic L, Jackson RW, Jackson RW, Jenner C, Joss M, Jové T, Kearney B, Kers JA, Kiiru JN, Koenig JE, Koenig JE, Krauland MG, Landgraf A, Larsson P, Leplae Rl, León G, Lipps HJ, Lloyd AL, Loftie-Eaton W, Lovell HC, Lovell HC, Manning SD, Marchetti M, Matz C, Maurelli AT, Mazel D, Michael CA, Michael CA, Morris CE, Morris CE, Moura A, Naas T, Nadarasah G, Naka H, Nawaz M, Ogura Y, Paauw A, Partridge SR, Pitman A, Poirel L, Poirel L, Ramirez MS, Rankin DJ, Rezzonico F, Rivas LA, Rodriguez-Martinez JM, Rohmer L, Rosewarne CP, Sajjad A, Salanoubat M, Salzberg SL, Seth-Smith H, Shaheen BW, Siguier P, Siguier P, Smillie C, Smith AB, Song H, Sota M, Steinberg KM, Sundin GW, Sundin GW, Tao L, Treangen TJ, van der Meer JR, van der Veen EL, van Essen-Zandbergen A, Wagner A, Waldor MK, Wiesner M, Woodford N, Yang H, Zhou Z, Zupan J   +120 more
core   +2 more sources

Autoregulation ensures vertical transmission of the linear prophage GIL01

Communications Biology
Betatectiviruses are prophages consisting of linear extrachromosomal genomes without obvious plasmid modules. It remains unclear how betatectiviruses are maintained in low-copy numbers in host cells and how they are vertically transmitted. Phage GIL01 is
Anja Pavlin, Nadine Fornelos, Maja Popović, Neža Praček, Gregor Bajc, Margarita Salas, Matej Butala   +6 more
doaj   +1 more source

Mining Thermophile Genomes for New PETases with Exceptional Thermostabilities Using Sequence Similarity Networks

ChemBioChem, Volume 26, Issue 12, June 16, 2025.
Targeted genome mining identified thermostable enzymes (PETases) that hydrolyze the commonly used plastic polymer polyethylene terephthalate (PET). Thermostable enzymes are identified from thermophilic microbial sources. Experimental results reveal enzymatic activity on authentic PET films, highlighting potential for industrial application.
Zhenyu Hu, Kody Klupt, David L. Zechel, Zongchao Jia, Graeme Howe   +4 more
wiley   +1 more source

Giant number fluctuations in microbial ecologies

, 2012
Statistical fluctuations in population sizes of microbes may be quite large depending on the nature of their underlying stochastic dynamics. For example, the variance of the population size of a microbe undergoing a pure birth process with unlimited ...
Das, Dibyendu, Das, Dipjyoti, Prasad, Ashok   +2 more
core   +1 more source

A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
Herein, a unique sulfotransferase, AdpST, is identified from the adp biosynthetic gene clusters (BGC) in Streptomyces davaonensis DSM101723 and demonstrates that AdpST possesses di‐sulfation activity, which is unprecedented for bacterial phosphoadenosine‐5’‐phosphosulfate (PAPS)‐dependent sulfotransferases. It is further shown that the adp BGC contains
Conor Pulliam, Lukuan Hou, Dan Xue, Mingming Xu, Katherine Holandez‐Lopez, Jie Li   +5 more
wiley   +1 more source

Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface [PDF]

, 2012
Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in nonpathogenic E.
Applegate, Bruce Michael, Kothapalli, Aparna, Morgan, Mark Thomas, Perry, Lynda Louise   +3 more
core   +1 more source