Results 111 to 120 of about 12,447 (204)

Novel GH115 xylan α‐1,2‐glucuronidases with distinct preferences for xylan‐derived oligomers and polymers

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract Natural polymers are promising sustainable materials for diverse applications. Xylans, major components of hemicellulose, exhibit origin‐dependent substitution patterns that determine their physicochemical properties. Targeted enzymatic modification of these substituents offers a mild and precise approach for tailoring the polymer's ...
Savvina Leontakianakou   +9 more
wiley   +1 more source

Autoregulation ensures vertical transmission of the linear prophage GIL01

open access: yesCommunications Biology
Betatectiviruses are prophages consisting of linear extrachromosomal genomes without obvious plasmid modules. It remains unclear how betatectiviruses are maintained in low-copy numbers in host cells and how they are vertically transmitted. Phage GIL01 is
Anja Pavlin   +6 more
doaj   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney   +12 more
wiley   +1 more source

Characterization of a Novel Thermobifida fusca Bacteriophage P318

open access: yesViruses, 2019
Thermobifida fusca is of biotechnological interest due to its ability to produce an array of plant cell wall hydrolytic enzymes. Nonetheless, only one T. fusca bacteriophage with genome information has been reported to date.
Jatuporn Cheepudom   +3 more
doaj   +1 more source

Optimal 1TEL–target protein linker character is target protein‐dependent

open access: yesActa Crystallographica Section D, Volume 82, Issue 5, Page 516-532, May 2026.
In this study, we examine the effect of short to medium‐length flexible, semi‐flexible and rigid linkers on the crystallization of a DARPin or the TNK1 UBA domain fused to the 1TEL protein crystallization chaperone, demonstrating that while rigid linkers can impair crystallization and reduce diffraction quality, the ideal linker character remains ...
Maria J. Pedroza Romo   +22 more
wiley   +1 more source

Systematic evaluation of phenotypic variations induced by prophages in a clinical isolate of Pseudomonas aeruginosa

open access: yesmSystems
With the rise of antibiotic resistance, nosocomial infections caused by Pseudomonas aeruginosa present a significant challenge to healthcare systems. Prophages integrated into bacterial chromosomes play a key role in generating phenotypic and genotypic ...
Xiaoyu Li   +9 more
doaj   +1 more source

A Novel Small Molecule Accelerates Early Persister Regrowth and Potentiates Antibiotic Killing via MdtL–DcrB

open access: yesMicrobial Biotechnology, Volume 19, Issue 5, May 2026.
bymBDZ accelerates early regrowth of persister‐derived E. coli and potentiates antibiotic killing. Its activity requires the MdtL–DcrB axis and is associated with envelope‐linked transport changes that increase intracellular small‐molecule exposure during recovery, thereby enhancing clearance in early treatment windows. ABSTRACT Persister cells survive
Garin Park, Hyein Kim, Sooyeon Song
wiley   +1 more source

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State

open access: yesAging Cell, Volume 25, Issue 5, May 2026.
This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, resulting in the maintenance of a fetal regenerative state in epithelial cells, insufficient tissue repair, and death of the animal.
Antonion Korcari   +10 more
wiley   +1 more source

Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles.

open access: yesPLoS Biology
Advances in metagenomics have led to the identification of new intestinal temperate bacteriophages. However, their experimental characterization remains challenging due to a limited understanding of their lysogenic-lytic cycle and the common lack of ...
Sol Vendrell-Fernández   +9 more
doaj   +1 more source

A Revised Understanding of Petalomonad Diversity (Petalomonadida; Euglenida) Enabled by a Cultivation Approach, With Five New Species and Two New Genera

open access: yesJournal of Eukaryotic Microbiology, Volume 73, Issue 3, May/June 2026.
ABSTRACT Euglenids are an important group of free‐living phototrophic, osmotrophic, or phagotrophic protists, with most of the phylogenetic diversity represented by phagotrophs. One major subgroup of phagotrophs is the petalomonads: rigid, often relatively small cells with few pellicle strips (usually 4–8).
Won Je Lee   +7 more
wiley   +1 more source

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