Results 111 to 120 of about 6,836 (201)

Clinicopathological characteristics of patients with inoperable non‐small cell lung cancer harboring circulating NRF2 pathway mutations

The Journal of Pathology, Volume 269, Issue 2, Page 164-181, June 2026.
Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen, Satu Tiainen, Jouni Kujala, Linnea Muhonen, Ponnuswamy Mohanasundaram, Tuomas Tikkanen, Ina Pöhner, Tommi Patinen, Simone Adinolfi, Juha P Väyrynen, Päivi Auvinen, Arto Mannermaa, Petri Pölönen, Tuomas Rauramaa, Anna‐Liisa Levonen   +14 more
wiley   +1 more source

New Finnlakevirus Isolate FLiP‐2 Provides Insight Into the Ecology of ssDNA Phages in Flavobacterium Hosts

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Despite the small genome size, ssDNA virus FLiP is remarkably well adapted to the seasonal variations of boreal fresh waters demonstrating excellent condition and host specific flexibility in its host interactions. FLiP plaques detected far from the original infection site represent a previously undescribed phenomenon, likely caused by the phage non ...
Kati Mäkelä, Elina Laanto, Reetta Penttinen, Janne Ravantti, Kim Kreuze, Lotta‐Riina Sundberg   +5 more
wiley   +1 more source

Isolation of a Novel Lytic Pseudomonas aeruginosa Phage Henu5 and Fitness Costs of Phage‐Driven Resistance

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
This study isolated and identified a novel lytic phage that infects Pseudomonas aeruginosa. Henu5 exhibited good physicochemical stability. Additionally, the phage‐resistant mutants showed fitness trade‐offs in growth, virulence and antibiotic susceptibility, along with in vivo fitness, which might direct future phage selection in clinical settings ...
Salwa E. Gomaa, Jiawen Shen, Jingjing Li, Yangyang Liu, Chaonan Ma, Qiming Li, Guanbin Qi, Tieshan Teng   +7 more
wiley   +1 more source

Characterisation and In Planta Activity of Bacteriophages That Infect the Key Bacterial Species Associated With Acute Oak Decline

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Phages that infect the oak pathogens Brenneria goodwinii and Gibbsiella quercinecans were isolated. The phages were able to effectively reduce bacterial populations of their respective hosts in vitro. However, when applied in planta, the phages did not reduce host populations and instead phages and bacteria co‐existed over time.
Emily R. Grace, Vanja Milenkovic, Katherine G. Hinton, Sabrine Dhaouadi, Diana Vinchira‐Villarraga, Michael A. Brockhurst, Mojgan Rabiey, Robert W. Jackson   +7 more
wiley   +1 more source

Exploring the lysogenic state of Sulfolobus spindle-shaped virus 1: the regulative role of the Ribbon-Helix-Helix viral protein F55

, 2014
Sulfolobus spindle-shaped virus 1 (SSV1) is the prototype and the most characterized member of the Fuselloviridae family (1). Upon infection, this fusellovirus establish a steady lysogenic state into the host cells.
AULITTO, MARTINA, FUSCO, SALVATORE, CONTURSI, PATRIZIA, Qunxin She, BARTOLUCCI, SIMONETTA   +4 more
core  

Viral lysis as top-down control of bacterial production in tropical waters of Peninsular Malaysia / Stanley Chai Choon Yip

, 2021
Viruses are the most abundant biological entities in the biosphere. Viruses infect host cells for replication and survival. Hence, viruses play important roles in the nutrient cycles and genetic transfer.
Stanley Chai , Choon Yip
core  

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Molecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang, Charlène Cornilleau, Lena Friebel, Sarah Spitzner, Raphael R. Müller, Doreen Meier, Pierre Flores, Cyprien Guérin, Pierre Nicolas, Diana Wolf, Vincent Fromion, Rut Carballido‐López, Thorsten Mascher   +12 more
wiley   +1 more source

Characterization of ES10 lytic bacteriophage isolated from hospital waste against multidrug-resistant uropathogenic E. coli

Frontiers in Microbiology
Escherichia coli is the major causative agent of urinary tract infections worldwide and the emergence of multi-drug resistant determinants among clinical isolates necessitates the development of novel therapeutic agents.
Aneela Nawaz, Sabeena Zafar, Abdulrahman H. Alessa, Nauman Ahmed Khalid, Muqaddas Shahzadi, Alina Majid, Malik Badshah, Aamer Ali Shah, Samiullah Khan   +8 more
doaj   +1 more source

Exploring the Lytic and Lysogenic Life Cycles of Bacteriophages

CourseSource, 2021
openaire   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source