Results 61 to 70 of about 6,836 (201)
Advanced NanoBiomed Research, EarlyView.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy +20 more
core +1 more source
High diversity in the regulatory region of Shiga toxin encoding bacteriophages
BMC Genomics, 2022 Background Enterohemorrhagic Escherichia coli (EHEC) is an emerging health challenge worldwide and outbreaks caused by this pathogen poses a serious public health concern.
Annette Fagerlund +3 more
doaj +1 more source
Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5
Biotechnology and Bioengineering, EarlyView.ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo +3 more
wiley +1 more source
New aspects of the environmental risks of quantum dots: prophage activation
, 2018 CdTe QDs induce lysogenic bacteria into the lytic cycle by damaging the DNA.
Huan He +8 more
core +1 more source
Bacterial ‘Grounded’ Prophages: Hotspots for Genetic Renovation and Innovation
Frontiers in Genetics, 2019 Bacterial genomes are highly plastic allowing the generation of variants through mutations and acquisition of genetic information. The fittest variants are then selected by the econiche thereby allowing the bacterial adaptation and colonization of the ...
Bhaskar Chandra Mohan Ramisetty +1 more
doaj +1 more source
Engineered B7‐H3 Binding in Modular Gp2 Miniproteins
Biotechnology and Bioengineering, EarlyView.ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn +5 more
wiley +1 more source
The Plant Pathology Journal, 2015 In order to control Pectobacterium carotovorum subsp. carotovorum, a novel virulent bacteriophage PM2 was isolated. Bacteriophage PM2 can infect 48% of P. carotovorum subsp. carotovorum and 78% of P. carotovorum subsp.
Jeong-A Lim, Dong Hwan Lee, Sunggi Heu
doaj +1 more source
Introducing Lu-1, a Novel Lactobacillus jensenii Phage Abundant in the Urogenital Tract.
PLoS ONE, 2020 Bacteriophages (phages) play a key role in shaping microbial communities, including those of the human body. Phages are abundant members of the urogenital tract, most often persisting through the lysogenic life cycle as prophages integrated within the ...
Taylor Miller-Ensminger +5 more
doaj +1 more source
Viruses under the Antarctic Ice Shelf are active and potentially involved in global nutrient cycles
Nature Communications, 2023 Viruses play an important role in the marine ecosystem. However, our comprehension of viruses inhabiting the dark ocean, and in particular, under the Antarctic Ice Shelves, remains limited.
Javier Lopez-Simon +5 more
doaj +1 more source