Results 31 to 40 of about 69 (65)

Molecular basis for lysophosphatidic acid receptor antagonist selectivity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Recent characterization of lysophosphatidic acid (LPA) receptors has made possible studies elucidating the structure-activity relationships (SAR) for agonist activity at individual receptors. Additionally, the availability of these receptors has allowed the identification of antagonists of LPA-induced effects.
Vineet M, Sardar, Debra L, Bautista, David J, Fischer, Kazuaki, Yokoyama, Nora, Nusser, Tamas, Virag, De-an, Wang, Daniel L, Baker, Gabor, Tigyi, Abby L, Parrill   +9 more
openaire   +3 more sources

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Regulation of silicosis formation by lysophosphatidic acid and its receptors

Experimental Lung Research, 2014
Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of silica-containing fine particles. Lysophosphatidic acid (LPA) and LPA1/3 plays a role in lung fibrosis. Until recently, there has been little research investigating the role of LPA and LPA receptors (LPAR) in silica-induced development ...
Cuicui, Cong, Lijun, Mao, Yanlin, Zhang, Zanmei, Zhao, Xixian, Xu, Jinyuan, Zhao   +5 more
openaire   +2 more sources

Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis

Scientific Reports, 2016
AbstractLysophosphatidic acid (LPA), a growth factor-like phospholipid, regulates numerous physiological functions, including cell proliferation and differentiation. In a previous study, we have demonstrated that LPA activates erythropoiesis by activating the LPA 3 receptor subtype (LPA3) under erythropoietin (EPO) induction.
Kuan-Hung Lin, Ya-Hsuan Ho, Jui-Chung Chiang, Meng-Wei Li, Shi-Hung Lin, Wei-Min Chen, Chi-Ling Chiang, Yu-Nung Lin, Ya-Jan Yang, Chiung-Nien Chen, Jenher Lu, Chang-Jen Huang, Gabor Tigyi, Chao-Ling Yao, Hsinyu Lee   +14 more
openaire   +2 more sources

Stereochemical properties of lysophosphatidic acid receptor activation and metabolism

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Ligand recognition by G protein-coupled receptors (GPCR), as well as substrate recognition by enzymes, almost always shows a preference for a naturally occurring enantiomer over the unnatural one. Recognition of lysophosphatidic acid (LPA) by its receptors is an exception, as both the natural L (R) and unnatural D (S) stereoisomers of LPA are equally ...
Kazuaki, Yokoyama, Daniel L, Baker, Tamas, Virag, Karoly, Liliom, Hoe Sup, Byun, Gabor, Tigyi, Robert, Bittman   +6 more
openaire   +2 more sources

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Lysophosphatidic Acid Receptors

Molecular Pharmacology, 2000
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression.
J J, Contos, I, Ishii, J, Chun
openaire   +2 more sources

Lysophosphatidic acid (LPA) and its receptors

Current Opinion in Pharmacology, 2009
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi, Deron, Herr, Tetsuji, Mutoh, Jerold, Chun   +3 more
openaire   +2 more sources

Lysophosphatidic acid: receptors, signaling and survival

Cellular and Molecular Life Sciences, 2000
Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions.
J T, Swarthout, H W, Walling
openaire   +2 more sources

The development of modulators for lysophosphatidic acid receptors: A comprehensive review

Bioorganic Chemistry, 2021
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse array of biological functions. They recognize two types of G protein-coupled receptors (LPARs): LPA1-3 receptors and LPA4-6 receptors that belong to the endothelial gene (EDG) family and non-endothelial gene family ...
Wenjie, Liu, Austin M, Hopkins, Jinqiang, Hou   +2 more
openaire   +2 more sources

Role of lysophosphatidic acid and its receptors in the kidney

Physiological Genomics, 2017
Lysophosphatidic acid (LPA) is a bioactive phospholipid that can exert diverse biological effects in various diseased states of the kidney by activating at least six cognate G protein-coupled receptors and its complex network of heterotrimeric G proteins.
Frank, Park, Duane D, Miller
openaire   +2 more sources