Results 91 to 100 of about 2,984,931 (176)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Identifying Co‐Expressed lncRNAs Correlated With Traits of Interest in an Animal Model for Metabolic Diseases in Humans

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Nutrigenomics investigates how nutrients modulate gene expression. Among them, fatty acids (FA) play important roles in regulating gene transcription, while long non‐coding RNAs (lncRNAs) may be associated with gene regulation and metabolic diseases.
Lucas Echevarria Nascimento, Bruna Pereira Martins da Silva, Camila Sabino de Oliveira, Mariah Castro Durval, Felipe André Oliveira Freitas, Fernanda Nery Ciconello, Izally Carvalho Gervásio, Simara Larissa Fanalli, Pablo Augusto de Souza Fonseca, Beatriz Gutiérrez‐Gil, Vivian Vezzoni de Almeida, Aline Silva Mello Cesar   +11 more
wiley   +1 more source

Life‐History, Stress‐Resistance, and Transcriptomic Variation Among a Mexican Caenorhabditis elegans Isolate and Contemporary and Ancestral N2 Lineages

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared a recently isolated wild strain of Caenorhabditis elegans from Mexico City (VJV2) with the contemporary standard N2 Lab strain and the cryopreserved N2 Ancestral lineage. The strains differed in lifespan, fertility, and survival under pathogen, oxidative, and heat stress.
Jaqueline Hersch‐González, Nallely Cano‐Domínguez, Mariana Zurita‐León, Francisco Pinta‐Castro, Maribel Soto‐Nava, Santiago Avila‐Rios, Victor Julian Valdes   +6 more
wiley   +1 more source

Lysosomal acid lipase A and the hypercholesterolaemic phenotype

, 2013
Mutations in lysosomal acid lipase A (LIPA) result in two phenotypes depending on the extent of lysosomal acid lipase (LAL) deficiency: the severe, early-onset Wolman disease or the less severe cholesteryl ester storage disease (CESD).
Fouchier, Sigrid W., Defesche, Joep C.
core   +1 more source

Anemia and nutrition deficiency in dental practice [PDF]

, 2016
Орофациалните признаци и симптоми, могат да бъдат първото клинично представяне на различните анемии и да насочат вниманите на денталните лекари за необходимо доизясняване на причините и консултация със съответните специалисти.
Krasteva, Assya Zaharieva; Faculty of Dental Medicine Medical University - Sofia
core   +1 more source

Could lysosomal acid lipase enzyme activity be used for clinical follow-up in cryptogenic cirrhosis?

, 2022
Background/aim: Cholesterol ester storage disease (CESD) is one of the rare causes that should be kept in mind in the etiology of cirrhosis. Recent studies detected that significantly reduced lysosomal acid lipase deficiency enzyme (LAL) in patients with
ENGİN KÖSE, HÜLYA AYAR KAYALI, AYAR KAYALI, HÜLYA, SEMİNAY GÜLER, Guler, Seminay, ELÇİN ÇAĞATAY, OKTAY, YAVUZ, ARSLAN, NUR, AKARSU, MESUT, KÖSE, ENGİN, Kisa, Pelin Teke, Kisa, PELİN, TUTKU YARAŞ MERCAN, YAVUZ OKTAY, MESUT AKARSU, Kayali, Hulya Ayar, Gulten, Zumrut Arslan, ZÜMRÜT ARSLAN GÜLTEN, Yaras, Tutku, PELİN TEKE KISA, NUR ARSLAN, Cagatay, Elcin   +21 more
core   +1 more source

Case Report: Wolman disease caused by LIPA variants in two Chinese infants and a focused literature synthesis

Frontiers in Pediatrics
BackgroundWolman disease is the severe infantile form of lysosomal acid lipase deficiency, caused by biallelic pathogenic variants in the Lysosomal Acid Lipase (LIPA) gene.
Leping Zhang, Qiong Yu, Xinjing Ge, Xinbao Xie   +3 more
doaj   +1 more source

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1816-1834, October 2026.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

Lysossomal acid lipase activity in dried blood spots - preliminar results [PDF]

, 2017
Lysosomal storage diseases (LSDs) are a group of heterogeneous and multisystemic disorders caused by defects in enzymes responsible for the intralysosomal degradation of particular compounds. One of them is Lysosomal Acid Lipase Deficiency (LALD) that is
Alves, Sandra, Gaspar, Paulo, Vilarinho, Laura   +2 more
core