Results 71 to 80 of about 2,984,931 (176)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

The Liver and Lysosomal Storage Diseases: From Pathophysiology to Clinical Presentation, Diagnostics, and Treatment

Diagnostics
The liver, given its role as the central metabolic organ, is involved in many inherited metabolic disorders, including lysosomal storage diseases (LSDs).
Patryk Lipiński, Anna Tylki-Szymańska
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Infant case of lysosomal acid lipase deficiency: Wolman's disease [PDF]

BMJ Case Reports, 2014
Lysosomal acid lipase (LAL) deficiency is a rare autosomal recessive disorder which causes two distinct clinical phenotypes: Wolman's disease and cholesterol ester storage disease. LAL hydrolyses LDL-derived triglycerides and cholesterol esters to glycerol or cholesterol and free fatty acids.
Meghmala, Sadhukhan, Amit, Saha, Roshni, Vara, Bim, Bhaduri   +3 more
openaire   +2 more sources

Lysosomal acid lipase deficiency in rats: lipid analyses and lipase activities in liver and spleen

Journal of Lipid Research, 1990
We report the biological characterization of an animal model of a genetic lipid storage disease analogous to human Wolman's disease. Affected rats accumulated cholesteryl esters (13.3-fold), free cholesterol (2.8-fold), and triglycerides (5.4-fold) in ...
M Kuriyama, H Yoshida, M Suzuki, J Fujiyama, A Igata   +4 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver Disease

, 2019
Objectives: Evidence suggests that lysosomal acid lipase deficiency (LAL-D) is often underdiagnosed because symptoms may be nonspecific. We aimed to investigate the prevalence of LAL-D in children with unexplained liver disease and to identify ...
Yaman, Aytac, Gumus, Meltem, Usta, Yusuf, Kansu, Aydan, Dogan, Yasar, Sahin, Gulseren, Urganci, Nafiye, Baran, Masallah, Hosnut, Ferda Ozbay, Durmaz Ugurcan, Ozlem, Onal, Zerrin, Islek, Ali, Gokce, Selim, Balcı Sezer, Oya, Balci Sezer, Oya, Eksi Bozbulut, Neslihan, Kırsaçlıoğlu, Ceyda Tuna, Dalgıç, Büket, Kuloglu, Zarife, Ozkan, Tanju, Eren, Esra, Agiı, Mehmet, ARSLAN, DURAN, Tosun, Mahya Sultan, Gulsan, Meltem, Eren, Makbule, Dalgic, Buket, Ozturk, Yesim, Gerenli, Nelgin, Celtik, Coskun, Çakır, Murat, Tokgoz, Yavuz, Hızlı, Samil, Gulerman, Fulya, Kuyum, Pinar, Guven, Burcu, Cakir, Murat, Bozbulut, Eksi, Ecevit, Cigdem Omur, KALAYCI, AYHAN GAZİ, Kasırga, Erhun, Kuyum, Pınar, Comba, Atakan, Agin, Mehmet, Urgancı, Nafiye, Natl Lal-D Study Grp, Hizli, Samil, Selbuz, Suna, Emiroglu, Halil Haldun, Usta, Ayse Merve, Kasirga, Erhun, Dogan, Guzide, Cantez, Serdar, Balamtekin, Necati, Aydogan, Aysen Uncuoglu, Demiroren, Kaan, Ozgur, Taner, Ozcay, Figen, Kocamaz, Halil, Kalayci, Ayhan G., Yuksekkaya, Hasan, Isik, Ishak Abdurrahman, Kirsaclioglu, Ceyda Tuna, Erdemir, Gulin, Kalaycı, Ayhan G., Akcam, Mustafa, Tumgor, Gokhan, Karacabey, Neslihan, Ustundag, Gonca Handan, Canan, Oguz, Deveci, Ugur   +70 more
core   +1 more source

TRPM2 Promotes Lipophagy Through TFEB and LAL in HFD-Fed Mice

Cells
An abnormality of Ca2+ signaling may aggravate lipid accumulation in steatotic hepatocytes, leading to non-alcoholic fatty liver disease. However, the molecular identity of Ca2+-permeable channels and the mechanism of involvement of these channels in ...
Fan Ying, Duan Zhuo, Shaobo Zhou, Liwen Jiang, Xiaoqiang Yao   +4 more
doaj   +1 more source

Mutations identified in a cohort of Mexican patients with lysosomal acid lipase deficiency

Annals of Hepatology, 2019
Introduction and Objectives: Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive disease caused by mutations in the LIPA gene, located on the long arm of chromosome 10 (10q23.31).
Alejandra Consuelo-Sánchez, Rodrigo Vázquez-Frias, Alejandra Reyes-De La Rosa, Carlos P. Acosta-Rodríguez-Bueno, María P. Ortal-Vite, Jorge J. Cebolla   +5 more
doaj   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source