BMEMat, EarlyView.A near‐infrared (NIR) light‐activated “lock‐key” nanodevice is reported for spatiotemporally resolved detection of intratumoral L‐lactate. The system stays silent until deep‐penetrating NIR light remotely unlocks its function, allowing for precise sensing within tumors.
Siyu Pan +8 more
wiley +1 more source
How to manage hypersensitivity reactions to enzyme replacement therapy in lysosomal storage diseases? [PDF]
Orphanet J Rare DisSpataro F +5 more
europepmc +1 more source
Altered blood-brain barrier transport of nanotherapeutics in lysosomal storage diseases. [PDF]
J Control Release, 2022 Solomon M +6 more
europepmc +1 more source
Status and future of recombinant adeno‐associated virus vector manufacturing
Biotechnology Progress, EarlyView.Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley +1 more source
Secondary accumulation of lyso-platelet activating factors in lysosomal storage diseases. [PDF]
Mol Genet MetabKell P +10 more
europepmc +1 more source
The Antifungal Antibiotic Filipin as a Diagnostic Tool of Cholesterol Alterations in Lysosomal Storage Diseases and Neurodegenerative Disorders. [PDF]
Antibiotics (Basel), 2023 Bruno F +3 more
europepmc +1 more source
Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release
Chemistry – A European Journal, EarlyView.Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source
A systematic review of economic evaluations of enzyme replacement therapy in Lysosomal storage diseases. [PDF]
Cost Eff Resour Alloc, 2022 Katsigianni EI, Petrou P.
europepmc +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía +3 more
wiley +1 more source
Unifying biology of neurodegeneration in lysosomal storage diseases. [PDF]
J Inherit Metab DisLudlaim AM, Waddington SN, McKay TR.
europepmc +1 more source