Results 171 to 180 of about 21,042 (237)

Drug-like screening, molecular docking, molecular dynamics simulations, and binding free energies on the interaction of pyrazole derivatives as inhibitors of lysosomal storage disorders and anticancer activity

Emmanuel Israel Edache, Adebiyi Adedayo, Hadiza Adamu Dawi, Fabian Audu Ugbe   +3 more
openalex   +1 more source

New Indications for Hematopoietic Stem Cell Gene Therapy in Lysosomal Storage Disorders

, 2022
Linda Rossini, Caterina Durante, Antonio Marzollo, Alessandra Biffi   +3 more
openalex   +1 more source

Fine‐Tuning Photochemical Immunogenic Cell Death by a Panel of Verteporfin‐Lipid Nanoparticles: A Data‐Driven Approach

Small Science, EarlyView.
The relationship between the attributes of verteporfin‐lipid nanoparticles and the exposure of immunogenic cell death markers (HSP‐70, HMGB1, and calreticulin) following 690 nm light activation in murine pancreatic cancer cells. Immunogenic cell death (ICD) is an immunostimulatory process that can be induced by light‐activated photosensitizers, but its
Nimit Shah, Maxwell Bortei Quaye, Siddharth Reddy Soma, Meghana Sree Vadlamudi, Doha Mahmoud, Ashritha Malkoochi, Taksheel Rao Aileni, Chanda Bhandari, Kunal Karambelkar, Tayyaba Hasan, Mladen Korbelik, Baowei Fei, Xinxin Song, Girgis Obaid   +13 more
wiley   +1 more source

Reply: Lysosomal storage disorder gene variants in multiple system atrophy [PDF]

, 2018
Joshua M. Shulman
openalex   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, EarlyView.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

Intracellular Delivery of β-Galactosidase Enzyme Using Arginase-Responsive Dextran Sulfate/Poly-l-arginine Capsule for Lysosomal Storage Disorder. [PDF]

ACS Omega, 2017
Gupta M, Pandey H, Sivakumar S.
europepmc   +1 more source

Age Deceleration and Reversal Gene Patterns in Dauer Diapause

Aging Cell, EarlyView.
The dauer diapause is a naturally occurring extraordinarily long‐lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we define the processes underlying the slowed aging during dauer and the rejuvenation during exit.
Khrystyna Totska, João C. V. V. Barata, Walter Sandt, David H. Meyer, Björn Schumacher   +4 more
wiley   +1 more source

Pressure for drug development in lysosomal storage disorders – a quantitative analysis thirty years beyond the US orphan drug act [PDF]

, 2015
Konstantin Mechler, William K. Mountford, Georg F. Hoffmann, Markus Ries   +3 more
openalex   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Fig4 deficiency: a newly emerged lysosomal storage disorder? [PDF]

Prog Neurobiol, 2013
Martyn C, Li J.
europepmc   +1 more source