Results 91 to 100 of about 249,586 (383)

Morpholinyl silicon phthalocyanine nanoparticles with lysosome cell death and two-photon imaging functions for in vitro photodynamic therapy of cancer cells

Frontiers in Bioengineering and Biotechnology, 2023
The lysosome is an important target for realizing antitumor therapy. Lysosomal cell death exerts significant therapeutic effects on apoptosis and drug-resistance. The development of lysosome-targeting nanoparticles to obtain efficient cancer treatment is
Hongjie Yu, Jianling Chen, Xiuqin Chen, Tiantian Zhang, Yuyang Li, Kuizhi Chen, Yiru Peng, Linying Chen   +7 more
doaj   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer [PDF]

, 2005
Lysosomal storage is the most common cause of neurodegenerative brain disease in preadulthood. However, the underlying cellular mechanisms that lead to neuronal dysfunction are unknown.
Bellen, Hugo J, Callaerts, Patrick, Dermaut, Bart, Kania, Artur, Norga, Koenraad K, Pan, Hongling, Verstreken, Patrik, Zhou, Yi   +7 more
core   +3 more sources

Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

eLife, 2020
Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In order to understand whether and how lysosomes alter with age and contribute to lifespan regulation, we characterized multiple properties of lysosomes during the aging
Yanan Sun, Meijiao Li, Dongfeng Zhao, Xin Li, Chonglin Yang, Xiaochen Wang   +5 more
semanticscholar   +1 more source

Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry

iScience, 2019
Summary: The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome ...
Kamalakannan Vijayan, Igor Cestari, Fred D. Mast, Elizabeth K.K. Glennon, Suzanne M. McDermott, Heather S. Kain, Alyssa M. Brokaw, John D. Aitchison, Kenneth Stuart, Alexis Kaushansky   +9 more
doaj   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Interaction of rat liver lysosomal membranes with actin. [PDF]

, 1984
Membranes were prepared from lysosomes purified 80-fold by centrifugation in a discontinuous metrizamide gradient. When salt-washed membranes were combined with rabbit muscle actin, an increase in viscosity could be measured using a falling ball ...
Bame, KJ, Mehrabian, M, Rome, LH
core  

Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction [PDF]

, 2015
Date of Acceptance: 02/02/2015 Copyright © 2015, American Society for Microbiology.
Bain, Judith M, Erwig, Lars-Peter, Gow, Neil A R, Lyall, Natalie, Okai, Blessing   +4 more
core   +2 more sources

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.

PLoS Pathogens
Mycobacterium tuberculosis (Mtb) infects lung myeloid cells, but the specific Mtb-permissive cells and host mechanisms supporting Mtb persistence during chronic infection are incompletely characterized.
Weihao Zheng, I-Chang Chang, Jason Limberis, Jonathan M Budzik, Beth Shoshana Zha, Zachary Howard, Lucas Chen, Joel D Ernst   +7 more
doaj   +1 more source

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

Scientific Reports, 2017
In neurodegenerative diseases, seeding is a process initiated by the internalization of exogenous protein aggregates. Multiple pathways for internalization of aggregates have been proposed, including direct membrane penetration and endocytosis.
Peizhou Jiang, Ming Gan, Shu-Hui Yen, Pamela J. McLean, Dennis W. Dickson   +4 more
doaj   +1 more source