Results 101 to 110 of about 231,658 (339)

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy. [PDF]

, 2018
Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined.
Adamo, Matthew A, Chang, Julia, Feustel, Paul, Gruenthal, Michael, Huang, Yunfei, Liao, Yuan, Mathern, Gary W, Mathur, Ramkumar, Mazurkiewicz, Joseph, Morgan, Shannon, Qian, Jiang, Ritaccio, Anthony L, Zhao, Xiaofeng, Zhu, Xinjun   +13 more
core   +2 more sources

Bioinspired Stabilization of Fluorescent Au@SiO2 Tracers for Multimodal Biological Imaging

Advanced Functional Materials, EarlyView.
This study demonstrates a bioinspired stabilization strategy for fluorescent gold‐silica nanoparticles. Inspired by natural biosilica maturation, high‐temperature calcination transforms the silica shells, preventing dissolution in cell culture media and intracellular environments.
Wang Sik Lee, Henry Lee, Patricia Taladriz‐Blanco, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +5 more
wiley   +1 more source

A cell-based assay for CD63-containing extracellular vesicles [PDF]

, 2019
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are few.
Cashikar, Anil G, Hanson, Phyllis I
core   +2 more sources

Lysosomes [PDF]

Current Biology, 2015
Wartosch, Lena, Bright, Nicholas A., Luzio, J. Paul   +2 more
openaire   +2 more sources

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Peripheral positioning of lysosomes supports melanoma aggressiveness

Nature Communications
Emerging evidence suggests that the function and position of organelles are pivotal for tumor cell dissemination. Among them, lysosomes stand out as they integrate metabolic sensing with gene regulation and secretion of proteases. Yet, how their function
Katerina Jerabkova-Roda, Marina Peralta, Kuang-Jing Huang, Antoine Mousson, Clara Bourgeat Maudru, Louis Bochler, Ignacio Busnelli, Rabia Karali, Hélène Justiniano, Lucian-Mihai Lisii, Philippe Carl, Vincent Mittelheisser, Nandini Asokan, Annabel Larnicol, Olivier Lefebvre, Hugo Lachuer, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Léa Scheid, Quentin Frenger, Frédéric Gros, Aurélie Hirschler, François Delalande, Emilie Sick, Raphaël Carapito, Christine Carapito, Dan Lipsker, Kristine Schauer, Philippe Rondé, Vincent Hyenne, Jacky G. Goetz   +31 more
doaj   +1 more source

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1 [PDF]

, 2011
<p><b>Background:</b> The three sub-species of <i>Trypanosoma brucei</i> are important pathogens of sub-Saharan Africa. <i>T. b.
A Cooper, A Tait, AM Shiflett, AM Shiflett, Annette MacLeod, AP Jackson, AP Jackson, B Vanhollebeke, B Vanhollebeke, B Vanhollebeke, C De Greef, C De Greef, C De Greef, C. Michael R. Turner, CM Turner, D Mehlitz, D Salmon, D Steverding, D Steverding, DG Godfrey, DJ Grab, E Pays, E Pays, F Bringaud, F Mathieu-daude, G Hide, G Hide, H Hirumi, HV Xong, J Barry, J Drain, J Lukes, J Raper, J Seed, J Widener, Jayne Raper, JC Enyaru, JC Ortiz, JM Harrington, JR Stevens, K Hager, KJ Livak, L Lecordier, L Vanhamme, LJ Morrison, M Becker, M Becker, M Berberof, M Berriman, M Kaern, M Ligtenberg, M Radwanska, Matthew Berriman, MP Molina-Portela, MR Rifkin, Nicola J. Veitch, NM Page, O Balmer, P Molina-Portela Mdel, P Paindavoine, P Poelvoorde, P Truc, Paul Capewell, Philippe Büscher, R Kieft, R Thomson, R Young, S Rozen, SC Welburn, SD Faulkner, SL Hajduk, Stephen L. Hajduk, U Zillmann, V Jamonneau, W Gibson, WC Gibson, WC Gibson, WC Gibson   +77 more
core   +5 more sources

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

A 3-D in vitro co-culture model of mammary gland involution. [PDF]

, 2014
Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru, Cameron, Ruth E., Campbell, Jonathan J., Davidenko, Natalia, Sargeant, Timothy J., Watson, Christine J.   +5 more
core   +3 more sources