Results 151 to 160 of about 231,658 (339)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+ Mobilization from Lysosomes in Pancreatic Acinar Cells

, 2010
François Cosker, Nathalie Cheviron, Michiko Yamasaki, Alexis Menteyne, Frances E. Lund, Marie‐Jo Moutin, Lianne C. Davis, José‐Manuel Cancela   +7 more
openalex   +1 more source

Estrogens, platelets and lysosomes [PDF]

, 2003
J. Polášek
openalex   +1 more source

Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor [PDF]

, 2020
Amy H. Ponsford, Thomas A. Ryan, Andrea Raimondi, Emanuele Cocucci, Susanne A. Wycislo, Florian Fröhlich, Laura E. Swan, Massimiliano Stagi   +7 more
openalex   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

TBC1D15-regulated mitochondria–lysosome membrane contact exerts neuroprotective effects by alleviating mitochondrial calcium overload in seizure

Scientific Reports
Mitochondrial calcium overload plays an important role in the neurological insults in seizure. The Rab7 GTPase-activating protein, Tre-2/Bub2/Cdc16 domain family member 15 (TBC1D15), is involved in the regulation of mitochondrial calcium dynamics by ...
Yinyin Xie, Wanwan Zhang, Tingting Peng, Xiaoyi Wang, Xiaolei Lian, Jiao He, Cui Wang, Nanchang Xie   +7 more
doaj   +1 more source

Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells

, 2010
Thilo Welsch, Alexander Younsi, Andrea Disanza, José Antonio Rodríguez, Ana María Cuervo, Giorgio Scita, Jan Schmidt   +6 more
openalex   +2 more sources

Lysosomes and prohormone activation [PDF]

, 1985
C. N. Hales
openalex   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

NO to Lysosomes: A Signal for Insulin Resistance in Obesity [PDF]

, 2019
Ali Javaheri, Abhinav Diwan
openalex   +1 more source