Results 281 to 290 of about 174,460 (337)

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting-Induced Proteolysis. [PDF]

J Cachexia Sarcopenia Muscle
Espino-Guarch M, Huang SSY, Vilches C, Prat E, El Nahas R, Missous G, Bodoy S, Sathappan A, Al-Aghbar MA, Mayayo C, Olivé M, Busquets-Rius S, Sebastián D, Zorzano A, Palacin M, van Panhuys N, Nunes V.   +16 more
europepmc   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

A Two-Photon Zn(II) Complex Photosensitizer with pH/Viscosity Dual Response for Enhanced Tumor Therapy. [PDF]

Molecules
Zhang Y, Guan SQ, Wang YP, Pan M.
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Mitochondrial Small RNA Alterations Associated with Increased Lysosome Activity in an Alzheimer's Disease Mouse Model Uncovered by PANDORA-seq. [PDF]

Int J Mol Sci
Zhang X, Shi J, Thakore P, Gonzales AL, Earley S, Chen Q, Zhou T, Feng Earley Y.   +7 more
europepmc   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

mTORC2 is crucial for regulating the recombinant Mycobacterium tuberculosis CFP-10 protein-induced phagocytosis in macrophages. [PDF]

BMC Immunol
Huang XH, Wang Y, Wu LY, Jiang YL, Ma LJ, Shi XF, Wang X, Zheng MM, Tang L, Lou YL, Xie DL.   +10 more
europepmc   +1 more source

Interfacial Engineering of Pillararene‐Modified Ceria Nanoparticles for Regulable Enhanced Sonodynamic Therapy

Aggregate, EarlyView.
The innovation of this work lies in the use of supramolecular interfacial effect of pillararene (CP5) to regulate the performance of CeOx by promoting the charge separation and transportation, which can enhance the SDT efficacy by large ROS generation and TME regulation.
Congcong Wang, Yanan Guo, Guoying Tan, Wanrong Kang, Wenjia Guo, Nan Song, Yu Tang   +6 more
wiley   +1 more source

N-Acetyl-l-Leucine (NALL) rescues inter-organelle communication in Niemann-Pick disease type-C patient cells

Kiraly S, Martello A, Platt FM, Eden ER.
europepmc   +1 more source

LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster. [PDF]

Cell Commun Signal
Yang W, Sun J, Guo Q, Wang W, Leng J, Wang L, Song L.   +6 more
europepmc   +1 more source