Results 81 to 90 of about 159,324 (248)

Insight into the Internal Structure of Biogenic, Synthetic and Geological Apatite by Electron Microscopy and X‐Ray Scattering

Advanced Functional Materials, EarlyView.
Apatite occurs in many forms in nature, e.g. in teeth and geological minerals. Internally, biological apatite contains nanocrystals that are also found in synthetically prepared calcium phosphate nanoparticles which are used in biomedicine, e.g. for gene and drug delivery and for bone regeneration. Abstract Calcium phosphate is the inorganic component (
Kathrin Kostka, Oleg Prymak, Kateryna Loza, Matthias Epple   +3 more
wiley   +1 more source

Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis

Journal of Lipid Research, 2014
Lysosomal integral membrane protein-2 (LIMP2) mediates trafficking of glucocerebrosidase (GBA) to lysosomes. Deficiency of LIMP2 causes action myoclonus-renal failure syndrome (AMRF).
Paulo Gaspar, Wouter W. Kallemeijn, Anneke Strijland, Saskia Scheij, Marco Van Eijk, Jan Aten, Herman S. Overkleeft, Andrea Balreira, Friederike Zunke, Michael Schwake, Clara Sá Miranda, JohannesM.F.G. Aerts   +11 more
doaj   +1 more source

Estrogens, platelets and lysosomes [PDF]

, 2003
J. Polášek
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Live Salmonella Modulate Expression of Rab Proteins to Persist in a Specialized Compartment and Escape Transport to Lysosomes [PDF]

, 2000
Shehla Hashim, Konark Mukherjee, Manoj Raje, Sandip K. Basu, Amitabha Mukhopadhyay   +4 more
openalex   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Lysosome targeted therapies in hematological malignancies

Frontiers in Oncology
Lysosomes are dynamic organelles integral to cellular homeostasis, secretory pathways, immune responses, and cell death regulation. In cancers, lysosomes become dysregulated to sustain proliferative signaling, metabolism, and invasion.
Madhumita S. Manivannan, Anthea Peters, Spencer B. Gibson   +2 more
doaj   +1 more source

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole [PDF]

, 2015
Cheuk Y. Ho, Christopher H. Choy, Christina A. Wattson, Danielle Johnson, Roberto J. Botelho   +4 more
openalex   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Synthetic Antiferromagnetic Designer Nanodisks for High‐Performance Magnetic Separation

Advanced Healthcare Materials, EarlyView.
Micromagnetic‐modeling‐based design and scalable fabrication of synthetic antiferromagnet (SAF) magnetic disk particles (MDPs) using sputter deposition enable high‐performance magnetic separation. The SAF MDPs achieve high colloidal stability and magnetic responsiveness and enable efficient magnetic separation, outperforming conventional particles ...
Subas Scheibler, Sebastian Habermann, Alexander Gogos, Santiago Helbig, Lukas R. H. Gerken, Anna L. Neuer, Vera M. Kissling, Michal Krupinski, Mohammad Alinezhadfar, Rowena Crockett, Nico Kummer, Erik M. Mayr, Dieter Süss, Hans J. Hug, Inge K. Herrmann   +14 more
wiley   +1 more source