Results 41 to 50 of about 1,586 (122)

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Genomic diversity and evolution of the lyssaviruses. [PDF]

PLoS ONE, 2008
Lyssaviruses are RNA viruses with single-strand, negative-sense genomes responsible for rabies-like diseases in mammals. To date, genomic and evolutionary studies have most often utilized partial genome sequences, particularly of the nucleoprotein and ...
Olivier Delmas, Edward C Holmes, Chiraz Talbi, Florence Larrous, Laurent Dacheux, Christiane Bouchier, Hervé Bourhy   +6 more
doaj   +1 more source

Novel applications of the tomato microbiome: Roles and considerations for agriculture, human health, and society

PLANTS, PEOPLE, PLANET, Volume 8, Issue 2, Page 530-555, March 2026.
Plants, like humans, have a microbiome that helps them grow, defend themselves against pathogens, acquire nutrients, and protect themselves against environmental stresses. The microbiome of tomatoes, a staple crop grown worldwide, could be utilized not only to reduce fertilizer and pesticide applications, but also to clean up harmful pollutants ...
Sean Lindert, Kathryn Kingsley, Peerapol Chiaranunt, James F. White   +3 more
wiley   +1 more source

The Role of Companion Animals as ‘Sentinels’ From the One Health Perspective

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
One Health emphasizes the interconnection of human, animal and environmental health. As emotional extensions of humans, companion dogs and cats can serve as sentinels, detecting hazards that can help protect human health from the One Health perspective. When symptoms appear in pets, owners should notice the changes that may pose risks to both human and
Shenchen Kang, Yu Chen, Mengmeng Liu
wiley   +1 more source

Taiwan Bat Lyssavirus: In Vitro and In Vivo Assessment of the Ability of Rabies Vaccine-Derived Antibodies to Neutralise a Novel Lyssavirus

Viruses, 2022
Rabies is a neglected tropical disease. The prototype virus, the rabies virus, still causes tens of thousands of human fatalities annually. Rabies is one member of the genus Lyssavirus. The burden of other lyssaviruses is unclear. The continued emergence
Rebecca Shipley, Edward Wright, Samuel P. Smith, David Selden, Anthony R. Fooks, Ashley C. Banyard   +5 more
doaj   +1 more source

Drivers of Viral Diversity and Sharing in Marine Mammals

Molecular Ecology, Volume 35, Issue 6, March 2026.
ABSTRACT Knowledge of viral infection in marine mammals, a group severely threatened by human activity, is largely limited to the pathology and epidemiology of few endemic viruses. The recent emergence in marine mammals of high‐consequence viruses, such as H5N1 avian influenza and rabies, underscores the importance of understanding the ecology of viral
Matthew J. Arnold, Laura M. Bergner, Haris Malik, Mariel ten Doeschate, Nicholas J. Davison, Andrew Brownlow, Nardus Mollentze, Simon A. Babayan, Daniel G. Streicker   +8 more
wiley   +1 more source

Lagos Bat Virus Infection Dynamics in Free-Ranging Straw-Colored Fruit Bats (Eidolon helvum)

Tropical Medicine and Infectious Disease, 2017
Bats are key species for ecological function, but they are also reservoirs of zoonotic agents, such as lyssaviruses that cause rabies. Little is known about the maintenance and transmission of lyssaviruses in bats, although the observation of clinically ...
Richard D. Suu-Ire, Anthony R. Fooks, Ashley C. Banyard, David Selden, Kofi Amponsah-Mensah, Silke Riesle, Meyir Y. Ziekah, Yaa Ntiamoa-Baidu, James L. N. Wood, Andrew A. Cunningham   +9 more
doaj   +1 more source

Major Causes of Rabies Outbreak in Pastoral Areas of the Somali Region and Importance of the One Health Approach

Animal Research and One Health, Volume 4, Issue 1, Page 28-35, February 2026.
Rabies Transmission and Control in the Somali Region. Introduction: Rabies is a fatal zoonotic disease caused by the Lyssavirus, posing a significant threat to both wildlife and public health in the Somali Region of Ethiopia. Key Points: 1. Primary Hosts: Wild carnivores such as foxes, jackals, raccoons, skunks, bats, and honey badgers are the main ...
Hassan Abdi Hussein
wiley   +1 more source

Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar, Magdi E. A. Zaki, Zeinab A. Muhammad, Dahlia A. Awwad, Sami A. Al‐Hussain, Chérif F. Matta, Refaie M. Kassab   +6 more
wiley   +1 more source

Isolation of Lagos Bat Virus from Water Mongoose

Emerging Infectious Diseases, 2006
A genotype 2 lyssavirus, Lagos bat virus (LBV), was isolated from a terrestrial wildlife species (water mongoose) in August 2004 in the Durban area of the KwaZulu-Natal Province of South Africa.
Wanda Markotter, Ivan V. Kuzmin, Charles E. Rupprecht, Jenny Randles, Claude T. Sabeta, Alexander I. Wandeler, Louis H. Nel   +6 more
doaj   +1 more source