Results 71 to 80 of about 3,219 (188)

Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar, Magdi E. A. Zaki, Zeinab A. Muhammad, Dahlia A. Awwad, Sami A. Al‐Hussain, Chérif F. Matta, Refaie M. Kassab   +6 more
wiley   +1 more source

Identification of rhabdoviral sequences in oropharyngeal swabs from German and Danish bats [PDF]

, 2014
BACKGROUND: In the frame of active lyssavirus surveillance in bats, oropharyngeal swabs from German (N = 2297) and Danish (N = 134) insectivorous bats were investigated using a newly developed generic pan-lyssavirus real-time reverse transcriptase PCR ...
Balkema-Buschmann, Anne, Beer, Martin, Chriél, Mariann, Fischer, Melina, Freuling, Conrad M., Hoffmann, Bernd, Müller, Thomas, Rasmussen, Thomas Bruun, Schatz, Juliane   +8 more
core   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Isolation of Lagos Bat Virus from Water Mongoose

Emerging Infectious Diseases, 2006
A genotype 2 lyssavirus, Lagos bat virus (LBV), was isolated from a terrestrial wildlife species (water mongoose) in August 2004 in the Durban area of the KwaZulu-Natal Province of South Africa.
Wanda Markotter, Ivan V. Kuzmin, Charles E. Rupprecht, Jenny Randles, Claude T. Sabeta, Alexander I. Wandeler, Louis H. Nel   +6 more
doaj   +1 more source

Taiwan Bat Lyssavirus: In Vitro and In Vivo Assessment of the Ability of Rabies Vaccine-Derived Antibodies to Neutralise a Novel Lyssavirus

Viruses, 2022
Rabies is a neglected tropical disease. The prototype virus, the rabies virus, still causes tens of thousands of human fatalities annually. Rabies is one member of the genus Lyssavirus. The burden of other lyssaviruses is unclear. The continued emergence
Rebecca Shipley, Edward Wright, Samuel P. Smith, David Selden, Anthony R. Fooks, Ashley C. Banyard   +5 more
doaj   +1 more source

Inhibition of caspase-1 prolongs survival of mice infected with rabies virus [PDF]

, 2018
Rabies virus infects almost all mammals resulting in lethal disease. To date there is no treatment available for symptomatic rabies and there is an urgent need to develop treatment strategies that would prolong survival, thereby providing a window of ...
Baumgärtner, V. (Volkmar), Begeman, L. (Lineke), D.M.E. Osterhaus, A. (Albert), Gerhauser, I. (Ingo), Koraka, P. (Penelope), Martina, B.E.E. (Byron), Marzec, A. (Anna), Orlowska, A. (Anna), Roose, J.M. (Jouke M.), Smreczak, M. (Marcin), Trebas, P. (Pawel), Wohlsein, P. (Peter), Zmudzinski, J. (Jan)   +12 more
core   +2 more sources

Diagnosis of Paralytic Rabies by Metagenomics Next‐Generation Sequencing: A Case Report and Review of the Literature

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
This case report demonstrates the successful diagnosis of a challenging paralytic rabies case using metagenomic next‐generation sequencing (mNGS). mNGS provided a rapid and precise pathogen identification directly from cerebrospinal fluid where traditional methods failed.
Lianghai Cao, Xingyu Wang, Youlian Zhou, Jun Qiu, Qianlv Zeng, Chaogui Zhang, Lingai Pan   +6 more
wiley   +1 more source

A Novel In‐Cell ELISA With Superior Sensitivity and Specificity for the Detection of African Swine Fever Virus‐Specific IgM and IgG Antibodies

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
African swine fever (ASF), a high‐profile transboundary animal disease caused by ASF virus (ASFV), imposes a devastating impact on the global swine industry. Given that vaccines are still under development, including field evaluations, early detection of ASFV is crucial for effective disease control and mitigation.
Ping Wu, Aric J. McDaniel, Yelitza Y. Rodríguez, Vivian O’Donnell, Wei Jia, Nan-hua Chen   +5 more
wiley   +1 more source

The Rabies Concert: Rising towards the Last Waltz?

Tropical Medicine and Infectious Disease, 2021
Apologies for the brief intermission imposed by the pandemic, between the opening piece of our Special Issue “Lyssaviruses and Rabies: Prevention, Control and Elimination” and this closing act of commentary [...]
Charles E. Rupprecht
doaj   +1 more source

Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses [PDF]

, 2015
IFN-induced transmembrane protein 3 (IFITM3) is a restriction factor that blocks cytosolic entry of numerous viruses that utilize acidic endosomal entry pathways. In humans and mice, IFITM3 limits influenza-induced morbidity and mortality.
Benfield, C., Benfield, C., Ferrara, F., Ferrara, F., Kellam, P., Kellam, P., Smith, S.E., Smith, S.E., Temperton, N.J., Temperton, N.J., Wash, R.S., Wash, R.S., Wright, E., Wright, E.   +13 more
core   +5 more sources