Results 121 to 130 of about 13,239 (158)
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Lysyl oxidase in colorectal cancer
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013Colorectal cancer is the third most prevalent form of cancer worldwide and fourth-leading cause of cancer-related mortality, leading to ∼600,000 deaths annually, predominantly affecting the developed world. Lysyl oxidase is a secreted, extracellular matrix-modifying enzyme previously suggested to act as a tumor suppressor in colorectal cancer. However,
Cox, Thomas R, Erler, Janine T
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Stability and purification of lysyl oxidase
Archives of Biochemistry and Biophysics, 1974Abstract Previous attempts to purify lysyl oxidase have been frustrated by the failure to recover activity during ion exchange or affinity chromatography. We have found that lysyl oxidase from chick cartilage shows marked stability in buffers containing urea and in these solutions can be recovered in high yield from DKAE-cellulose and collagen ...
A S, Narayanan, R C, Siegel, G R, Martin
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On the inhibition of lysyl oxidase by β-aminopropionitrile
Biochemical and Biophysical Research Communications, 1972Summary β-Aminopropionitrile binds to and inactivates lysyl oxidase, the enzyme carrying out the first step in the cross-linking of collagen and elastin.
A S, Narayanan, R C, Siegel, G R, Martin
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Lysyl oxidase in cancer inhibition and metastasis
Cancer Letters, 2018Lysyl oxidase is an extracellular matrix, copper - dependent amine oxidase that catalyzes a key enzymatic step in the crosslinking of collagen and elastin. The enzyme is synthesized as a propeptide that is cleaved by procollagen - C - proteinase into two distinct parts: the mature form and the LOX propeptide.
Karlo M Lopez
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Lysyl oxidase expression in bronchogenic carcinoma
American Journal of Surgery, 2005Lysyl oxidase catalyzes a key step in the cross-linking of collagen and elastin in the extracellular matrix. Recent studies have documented differential lysyl oxidase expression in the stromal reaction to colon, breast, prostate, and lung cancer. The present study was undertaken to test the hypothesis that lysyl oxidase mRNA and protein expression ...
Rose E Callahan +2 more
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Respirology, 2015
Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness of the tissue, are not well understood.
Tjin, G. +4 more
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Aim: The development of fibrosis in Idiopathic Pulmonary Fibrosis (IPF) is a key feature and challenge in the treatment of the disease. The mechanisms of collagen I (COL1) reorganisation in the development of fibrosis, which may alter the stiffness of the tissue, are not well understood.
Tjin, G. +4 more
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Lysyl Oxidase Isoforms in Gastric Cancer
Biomarkers in Medicine, 2016Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular matrix crosslinking enzymes, should be considered as potential biomarkers and therapeutic targets in GC.
Carolina, Añazco +7 more
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Active site chemistry of lysyl oxidase
Journal of Inorganic Biochemistry, 1987The bimolecular reduction of the Cu(II)-based enzyme lysyl oxidase with two inorganic reductants, tris bipyridylchromium(II) and (1,3,6,8,10,13,16,19)-octaazabicyclo (6,6,6)eicosanecobalt(II) has been examined at various ionic strength and [H+] conditions. The electrochemical properties of the enzyme have also been examined. The results show that Cu(II)
K, Govindaraju +3 more
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1989
The pH dependency of steady-state kinetic parameters and the results of chemical modification of lysyl oxidase by diethylpyrocarbonate has identified an enzyme residue with a pKa of 7.0 ± 0.1 and an enthalpy of ionization of 6.1 kcal mole-1, consistent with an active site histidine residue.
Herbert M. Kagan +4 more
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The pH dependency of steady-state kinetic parameters and the results of chemical modification of lysyl oxidase by diethylpyrocarbonate has identified an enzyme residue with a pKa of 7.0 ± 0.1 and an enthalpy of ionization of 6.1 kcal mole-1, consistent with an active site histidine residue.
Herbert M. Kagan +4 more
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Immunological characterization of bovine lysyl oxidase
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1985Antibodies to homogeneously purified bovine aortic lysyl oxidase were prepared in chickens. The chicken anti-lysyl oxidase antiserum effectively inhibited bovine aortic lysyl oxidase activity. Non-immune antiserum from chickens, goats and humans was found to enhance bovine aortic lysyl oxidase activity, while non-immune rabbit serum inhibited enzyme ...
Burbelo, P. D. +2 more
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