Results 111 to 120 of about 155,219 (227)
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
MedComm, Volume 7, Issue 10, October 2026.A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
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Iron and Other Metal Ions in Human Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
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Transient expression of lysyl oxidase in the lungs of mice
, 1996 Lysyl oxidase is an attractive candidate gene for gene therapy of lung cancer because of its tumour suppressor activity (Contente et al., 1990; Kenyon and Contente, 1991; Tsan et al., 1996) and secretion in the extracellular matrix of the lungs (Kagan et
Koch, Birgit K.
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Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
MedComm, Volume 7, Issue 10, October 2026.The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
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The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.
, 2004 International audienceLysyl oxidase is an extracellular enzyme critical for the normal biosynthesis of collagens and elastin. In addition, lysyl oxidase reverts ras-mediated transformation, and lysyl oxidase expression is down-regulated in human cancers.
Jeay, S. +6 more
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Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure [PDF]
, 2009 The aim of this study was to investigate whether torasemide modifies collagen cross-linking in the failing human heart. We analyzed the degree of cross-linking and the expression of the enzyme lysyl oxidase, which regulates cross-linking, in the ...
Larman, M. (Mariano) +5 more
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British Journal of Haematology, Volume 209, Issue 4, Page 1450-1468, October 2026.Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo +3 more
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Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis
, 2013 International audienceCellular senescence, a stable proliferation arrest, is induced in response to various stresses. Oncogenic stress-induced senescence (OIS) results in blocked proliferation and constitutes a fail-safe program counteracting ...
Treilleux, I +14 more
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British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
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Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.
, 1981 This study assessed the responses of lysyl oxidase, the enzyme that initiates covalent crosslinking in elastic and collagen, by studying the aortic tissue of rabbits after arteriosclerosis had been induced by diet.
J Raghavan, W Hollander, H M Kagan
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