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A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer [PDF]
, 2019 Baranski, Thomas +8 more
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Human lysyl oxidase-like 2 [PDF]
Bioorganic Chemistry, 2014 Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin.
Hee-Jung Moon +2 more
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A micromethod for the purification of lysyl oxidase
Analytical Biochemistry, 1982Abstract A simple, efficient, and rapid procedure for the purification of lysyl oxidase is described. This method utilizes an affinity scheme involving powdered elastin-hydroxyethylmethacrylate hydrogels and high-performance liquid chromatography and permits the study of enzyme from sources which contain limited amounts of enzyme, such as aortic ...
R, Ferrera +4 more
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Lysyl Oxidases: Functions and Disorders
Journal of Glaucoma, 2018Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize lysyl and hydroxylysyl residues in collagen and elastin, as a first step in the stabilization of these extracellular matrix proteins through the formation of covalent cross-linkages, an essential process for connective tissue maturation.
Fernando, Rodriguez-Pascual +1 more
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Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1994
Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system.
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Lysyl oxidase initiates crosslink formation of the collagen and elastin extracellular matrix, thereby delimiting its expansive properties. Recently lysyl oxidase has been cloned from several species enabling the computation of the relative order of appearance of the various components of this enzyme system.
openaire +2 more sources
An ultrafiltration assay for lysyl oxidase
Analytical Biochemistry, 1990A modification of the original microdistillation assay for lysyl oxidase is described in which Amicon C-10 microconcentrators are used to separate, by ultrafiltration, the 3H-labeled products released from a [4,5-3H]-lysine-labeled elastin substrate.
D R, Shackleton, D J, Hulmes
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Lysyl Oxidase and Lysyl Oxidase-Like Enzymes
2010Lysyl oxidase (LOX) and its four congeners, lysyl oxidase-like 1 (LOXL1), -2, -3, and -4, have received much investigative attention in recent years. LOX itself, is the prototypic form of these amine oxidase enzymes. LOX has long been considered to function exclusively as the enzyme that oxidizes peptidyl lysine in its collagen and elastin substrates ...
Herbert M. Kagan, Faina Ryvkin
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Lysyl Oxidase in Cancer Research
Future Oncology, 2014Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target.
Perryman, Lara, Erler, Janine Terra
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A microassay for lysyl oxidase activity
Analytical Biochemistry, 1976Abstract Pinnell and Martin's [(1968) Proc. Nat. Acad. Sci. USA61, 708–716] standard assay for lysyl oxidase is modified to determine activity in small samples. Data collected by both methods are comparable, and the microassay has the advantages of being economical and rapid.
Misiorowski, Ronald L. +2 more
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Properties and Function of Lysyl Oxidase
American Journal of Respiratory Cell and Molecular Biology, 1991Abstract Lysyl oxidase catalyzes the oxidation of peptidyl lysine to α-aminoadipic-δ-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone.
H M, Kagan, P C, Trackman
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