Results 91 to 100 of about 155,219 (227)

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

The regulation of lysyl oxidase by bFGF and TGF-B1 in osteoblastic MC3T3-E1 Cells [PDF]

, 1995
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1995 (Oral Biology).Includes bibliographical references: (leaves 57-73).Lysyl oxidase catalyzes the enzymatic step that is limiting for collagen and elastin crosslinking.
Feres-Filho, Eduardo Jorge
core   +1 more source

Comparing the expression patterns and differences of LOX and LOXL1 during the development of myodural bridge and ligamentum flavum

Frontiers in Cell and Developmental Biology
The ligamentum flavum (LF) is a passive stabilizing tissue that connects two adjacent vertebral arches and contributes to the enclosure the spinal canal, thereby closing the entire canal posteriorly.
Yi-tong Sun, Zhao-ran Li, Hua-xun Lai, Wei Ma, Chan Li, Ji-hang Li, Yan-yan Chi, Sheng-bo Yu, Nan Zheng, Bo Liu, Jian-fei Zhang, Hong-jin Sui   +11 more
doaj   +1 more source

Therapeutic Reversal of Severe Neuropsychiatric Symptoms in Wilson's Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Wilsons disease is an autosomal recessive genetic disorder of copper metabolism that results in copper accumulation in liver and other organs. Hepatic manifestation tends to occur earlier than the neurological manifestation. We present a case with psychiatric presentation.
Tshering Penjor, Sangay Dorji, Sonam Wangchuk   +2 more
wiley   +1 more source

Kinetics and stereospecificity of the lysyl oxidase reaction

Journal of Biological Chemistry, 1993
The structural specificity of amine oxidation by lysyl oxidase was investigated using kinetic and NMR spectroscopic analyses. Substrate efficiency increased with increasing molecular distance from the alpha-carbon of the aromatic moiety substituted on the aliphatic chains of a series of primary amines. The p-hydroxyl substituent of p-hydroxybenzylamine
M A, Shah, C H, Scaman, M M, Palcic, H M, Kagan   +3 more
openaire   +2 more sources

Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis

Journal of Inflammation
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology related to lung fibrosis, whereas the mechanism that ETS exposure augments pulmonary fibrogenesis is unclear.
Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman   +3 more
doaj   +1 more source

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1184-1196, November 2026.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

Structure of the Mouse Lysyl Oxidase Gene

Genomics, 1993
Lysyl oxidase, an extracellular enzyme involved in the maturation of collagen and elastin, also appears to function as a phenotypic suppressor of transformation by the ras gene product, p21. Genomic clones of the mouse lysyl oxidase gene have been isolated, analyzed, and sequenced.
S, Contente, K, Csiszar, K, Kenyon, R M, Friedman   +3 more
openaire   +2 more sources

LYSYL OXIDASE INHIBITORS

, 2017
This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of ...
ZAMBON, Alfonso, LEUNG, Leo, SPRINGER, Caroline, MARAIS, Richard, BROWN, Michael, TANG, Haoran, ALJARAH, Mohammed, MILLER, Natalie, NICULESCU-DUVAZ, Dan, SMITHEN, Deborah   +9 more
core  

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2017
Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source