Results 91 to 100 of about 13,239 (158)

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

, 2020
Arterial tortuosity syndrome (ATS) is a recessively inherited connective tissue disorder, mainly characterized by tortuosity and aneurysm formation of the major arteries.
Barnhoorn, Sander, Beyens, Aude, Boel, Annekatrien, Burger, Joyce, Callewaert, Bert, Casteleyn, Christophe, Coucke, Paul, Descamps, Benedicte, Essers, Jeroen, Reinhardt, Dieter, Renard, Marjolijn, van der Pluijm, Ingrid, Vanhomwegen, Marine, Vanhove, Christian, Willaert, Andy   +14 more
core   +1 more source

Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

Nature Communications, 2016
Lysyl oxidase-like 2 (LOXL2) is an enzyme that promotes scaffolding of extracellular matrix proteins. Here the authors show that LOXL2 is crucial for pressure-overload induced cardiac fibrosis, and that antibody-mediated inhibition or genetic disruption ...
Jin Yang, Konstantinos Savvatis, Jong Seok Kang, Peidong Fan, Hongyan Zhong, Karen Schwartz, Vivian Barry, Amanda Mikels-Vigdal, Serge Karpinski, Dmytro Kornyeyev, Joanne Adamkewicz, Xuhui Feng, Qiong Zhou, Ching Shang, Praveen Kumar, Dillon Phan, Mario Kasner, Begoña López, Javier Diez, Keith C. Wright, Roxanne L. Kovacs, Peng-Sheng Chen, Thomas Quertermous, Victoria Smith, Lina Yao, Carsten Tschöpe, Ching-Pin Chang   +26 more
doaj   +1 more source

Collagens - structure, function and biosynthesis. [PDF]

, 2003
The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions.
Aigner, T, Gelse, K, Poschl, E
core   +1 more source

UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling

Cell Reports
Summary: The intricate interplay between resident cells and the extracellular matrix (ECM) profoundly influences cancer progression. In triple-negative breast cancer (TNBC), ECM architecture evolves due to the enrichment of lysyl oxidase, fibronectin ...
Swagata Adhikari, Vipin Singh, Sandhik Nandi, Manorama Ghosal, Nidharshan Sundar Raj, Jayati Khanna, Apoorva Bhattacharya, Aindrila Kabiraj, Atanu Mondal, Madavan Vasudevan, Dulal Senapati, Himansu Roy, Kundan Sengupta, Dimple Notani, Chandrima Das   +14 more
doaj   +1 more source

Enzyme-catalyzed protein crosslinking [PDF]

, 2018
The process of protein crosslinking comprises the chemical, enzymatic, or chemoenzymatic formation of new covalent bonds between polypeptides. This allows (1) the site-directed coupling of proteins with distinct properties and (2) the de novo assembly of
Faccio, Greta, Heck, Tobias, Richter, Michael, Thöny-Meyer, Linda   +3 more
core  

RAGE Signaling in Skeletal Biology [PDF]

, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M., Essex, Alyson L., Plotkin, Lilian I.   +2 more
core   +2 more sources

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes.
Olson, Michael F., Pajic, Marina, Rath, Nicola, Timpson, Paul, Vennin, Claire   +4 more
core   +1 more source

How reliable and robust are current biomarkers for copper status? [PDF]

, 2017
Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects.
Araya, Magdalena, Danzeisen, Ruth, Harrison, Brenda, Keen, Carl, McArdle, Harry J., Solioz, Marc, Thiele, Dennis   +6 more
core  

Downregulation of lysyl oxidase protects retinal endothelial cells from high glucose–induced apoptosis [PDF]

, 2017
Kim, Dongjoon, Mecham, Robert P, Roy, Sayon, Trackman, Philip C   +3 more
core   +2 more sources

Hydrogen sulfide generated by cystathionine gamma lyase inhibits lysyl oxidase and protects against calcific tendinopathy

Journal of Orthopaedic Translation
Background/objective: Increased lysyl oxidase (LOX) activity favors pathologic cartilage and vessel calcification. LOX promotes disease through enhanced collagen cross-linking, inflammation, reactive oxygen species (ROS) production, cell trans ...
Elodie Faure, Ilaria Bernabei, Driss Ehirchiou, Philipp Michel, Daniel Kronenberg, Thomas Pap, Giuseppe Cirino, Richard Stange, Nathalie Busso, Sonia Nasi   +9 more
doaj   +1 more source